(Q36596684)

15 August 2017

1 reference

title

Is caveolin-1 a viable therapeutic target to reduce cancer metastasis? (English)

1 reference

15 August 2017

1 reference

Kenneth L van Golen

1

1 reference

PubMed ID

16981828

15 August 2017

language of work or name

English

0 references

publication date

1 October 2006

1 reference

Expert Opinion on Therapeutic Targets

15 August 2017

1 reference

15 August 2017

10

1 reference

15 August 2017

5

1 reference

15 August 2017

709-721

1 reference

Emerging themes in lipid rafts and caveolae.

15 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Sphingolipid signalling domains floating on rafts or buried in caves?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Cell biology of caveolae and caveolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin, a protein component of caveolae membrane coats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

21 January 2018

The caveolin proteins

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

21 January 2018

Structure of caveolae

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolins in cholesterol trafficking and signal transduction: implications for human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Reduction of caveolin and caveolae in oncogenically transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Reduction of caveolin 1 gene expression in lung carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Impact of caveolin-1 expression on clinicopathological parameters in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Cell migration: Rho GTPases lead the way

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Differential gene expression in metastasizing cells shed from kidney tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

The biphasic differential expression of the cellular membrane protein, caveolin-1, in oral carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Mutational analysis of the properties of caveolin-1. A novel role for the C-terminal domain in mediating homo-typic caveolin-caveolin interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

VIP21/caveolin is a cholesterol-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

The cyclin D1 gene is transcriptionally repressed by caveolin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Fish mapping of YAC clones at human chromosomal band 7q31.2: identification of YACS spanning FRA7G within the common region of LOH in breast and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Definitive functional evidence for a tumor suppressor gene on human chromosome 7q31.1 neighboring the Fra7G site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

DNA methylation and the regulation of gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

The essentials of DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Hypermethylation of the caveolin-1 gene promoter in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin-1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascades transcriptionally down-regulates caveolin-1 promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Molecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

The current understanding of the molecular determinants of inflammatory breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Localization of RhoA GTPase to endothelial caveolae-enriched membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Association of p75(NTR) with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Evidence for a regulated interaction between heterotrimeric G proteins and caveolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Inhibition of PKCalpha and rhoA translocation in differentiated smooth muscle by a caveolin scaffolding domain peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

The epidermal growth factor receptor in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Inflammatory breast cancer: relationship between growth factor signaling and motility in aggressive cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Activation of extracellular-regulated kinases by normal and mutant EGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Regulated migration of epidermal growth factor receptor from caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Localization of phospholipase C-gamma1 signaling in caveolae: importance in EGF-induced phosphoinositide hydrolysis but not in tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Molecular requirements for epithelial-mesenchymal transition during tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Rho GTPases and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

The cellular functions of small GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

G-proteins as transducers in transmembrane signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Mechanisms for reversible regulation between G13 and Rho exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

RhoA- and RhoD-dependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Integrin expression regulates neuroblastoma attachment and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Integrin-linked kinase complexes with caveolin-1 in human neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

21 January 2018

Signaling to Rho GTPases

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Rho GTPase signalling pathways in the morphological changes associated with apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

A novel ras-related gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Rho proteins induce metastatic properties in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Rho GTPases in cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

21 January 2018

RHO-GTPases and cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Guanine nucleotide exchange factors: activators of Ras superfamily proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

GTPase-activating proteins: helping hands to complement an active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

GTPase-activating proteins and their complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

A PLCdelta1-binding protein, p122/RhoGAP, is localized in caveolin-enriched membrane domains and regulates caveolin internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Expression of caveolin-1 and its correlation with cisplatin sensitivity in oral squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1 is expressed on multipotent cells of hair follicles and might be involved in their resistance to chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Metastasis: a question of life or death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1 expression enhances endothelial capillary tubule formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Cell confluence-dependent remodeling of endothelial membranes mediated by cholesterol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

In vivo prenylation analysis of Ras and Rho proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Somatostatin, acting at receptor subtype 1, inhibits Rho activity, the assembly of actin stress fibers, and cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Potential vascular benefits of statins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Combined endothelial nitric oxide synthase upregulation and caveolin-1 downregulation decrease leukocyte adhesion in pial venules of ovariectomized female rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1 is associated with VCAM-1 dependent adhesion of gastric cancer cells to endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Pharmacological inhibitors of MAPK pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Rho proteins: targets for bacterial toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1 as a potential new therapeutic target in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1, a putative tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1 inhibits breast cancer growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Epidermal Growth Factor-stimulated Tyrosine Phosphorylation of Caveolin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

Epidermal Growth Factor-mediated Caveolin Recruitment to Early Endosomes and MAPK Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.5.709

10.1517/14728222.10.5.709

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

16981828