(Q36597647)

15 August 2017

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title

Nanomedicine: clinical applications of polyethylene glycol conjugated proteins and drugs (English)

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15 August 2017

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Suphiya Parveen

1

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15 August 2017

Sanjeeb K Sahoo

series ordinal

2

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15 August 2017

publication date

1 January 2006

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Clinical Pharmacokinetics

15 August 2017

published in

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15 August 2017

volume

45

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15 August 2017

issue

10

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15 August 2017

page(s)

965-988

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Doxorubicin-polymer conjugates: further demonstration of the concept of enhanced permeability and retention

15 August 2017

cites work

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12 December 2020

Cancer-targeted polymeric drugs

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12 December 2020

The Food and Drug Administration's Office of Orphan Products Development: incentives, grants, and special designations speed therapies for orphan diseases

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12 December 2020

Determination of free amino groups in proteins by trinitrobenzenesulfonic acid

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12 December 2020

Hepatic excretion and metabolism of polyethylene glycols and mannitol in the cat

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12 December 2020

Clinical trials with Dismutec (pegorgotein; polyethylene glycol-conjugated superoxide dismutase; PEG-SOD) in the treatment of severe closed head injury

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12 December 2020

Phase I study of CT-2103, a polymer-conjugated paclitaxel, and carboplatin in patients with advanced solid tumors

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12 December 2020

Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase: a phase II trial

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12 December 2020

A phase II trial of PEG-L-asparaginase in the treatment of non-Hodgkins lymphoma

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12 December 2020

Increased tissue oxygenation and enhanced radiation sensitivity of solid tumors in rodents following polyethylene glycol conjugated bovine hemoglobin administration

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12 December 2020

Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: a multicenter dose-finding study in women with breast cancer

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12 December 2020

Fate of water-soluble polymers administered via different routes.

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12 December 2020

CT-2103: a novel macromolecular taxane with potential advantages compared with conventional taxanes.

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12 December 2020

Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli L-asparaginase.

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12 December 2020

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12 December 2020

Mono-N-terminal poly(ethylene glycol)-protein conjugates

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12 December 2020

Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.

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12 December 2020

Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee

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12 December 2020

Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol

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12 December 2020

Chemistry for peptide and protein PEGylation

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12 December 2020

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs

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12 December 2020

Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel

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12 December 2020

Introduction and overview of peptide and protein pegylation

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12 December 2020

PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimisation of coupling techniques

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12 December 2020

Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates

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12 December 2020

Drug-polymer conjugates: potential for improved chemotherapy

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12 December 2020

Pegylation: engineering improved pharmaceuticals for enhanced therapy

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12 December 2020

Determinants of drug delivery and transport to solid tumors

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12 December 2020

TUMOR INHIBITORY EFFECT OF L-ASPARAGINASE FROM ESCHERICHIA COLI

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12 December 2020

Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies

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12 December 2020

Therapeutic antibody fragments with prolonged in vivo half-lives

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12 December 2020

Protein and peptide parenteral controlled delivery

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12 December 2020

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment

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12 December 2020

Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells--a mechanism of immune evasion?

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12 December 2020

A dose-ranging study of pegylated interferon alfa-2b and ribavirin in chronic hepatitis C. The Hepatitis C Intervention Therapy Group

1 reference

12 December 2020

Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-stimulating factor mutein

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12 December 2020

Effect of pegylation on pharmaceuticals

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12 December 2020

Biological activities of polyethylene-glycol immunoglobulin conjugates. Resistance to enzymatic degradation

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12 December 2020

Effective drug delivery by PEGylated drug conjugates

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12 December 2020

PEGylated antibodies and antibody fragments for improved therapy: a review

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12 December 2020

Paul Ehrlich--in search of the magic bullet

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12 December 2020

Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

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12 December 2020

Modulation of the pharmacokinetics and pharmacodynamics of proteins by polyethylene glycol conjugation

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12 December 2020

Anticancer drug delivery systems: multi-loaded N4-acyl poly(ethylene glycol) prodrugs of ara-C. II. Efficacy in ascites and solid tumors

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12 December 2020

Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase

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12 December 2020

Chemotherapy targeted to cancers through tumoral hormone receptors

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12 December 2020

Polymer conjugates for tumour targeting and intracytoplasmic delivery. The EPR effect as a common gateway?

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12 December 2020

Immunogenicity of polyethylene glycol-modified superoxide dismutase and catalase

1 reference

12 December 2020

What is nanomedicine?

1 reference

12 December 2020

Selective synthesis of 2,4-bis(O-methoxypolyethylene glycol)-6-chloro-s-triazine as a protein modifier

1 reference

12 December 2020

Preparation of a polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity

1 reference

12 December 2020

Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer

1 reference

12 December 2020

Predictive modeling for the presence of prostate carcinoma using clinical, laboratory, and ultrasound parameters in patients with prostate specific antigen levels ≤ 10 ng/mL

1 reference

12 December 2020

HPMA copolymer platinates as novel antitumour agents: in vitro properties, pharmacokinetics and antitumour activity in vivo

1 reference

12 December 2020

Apoptosis by death factor

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12 December 2020

Functionalized Poly(ethylene glycols) for Preparation of Biologically Relevant Conjugates

1 reference

12 December 2020

A randomized, double-blind, placebo-controlled, phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia. The International Acute Myeloid Leukemia Study Group

1 reference

12 December 2020

Pegaptanib: in exudative age-related macular degeneration

1 reference

12 December 2020

Strategies for targeting tumour necrosis factor in IBD.

1 reference

12 December 2020

Identification of tumour-associated T-cell epitopes for vaccine development

1 reference

12 December 2020

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

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12 December 2020

Pegaspargase: a review of clinical studies

1 reference

12 December 2020

An improved 2,4,6-trinitrobenzenesulfonic acid method for the determination of amines

1 reference

12 December 2020

Drug delivery systems: past, present, and future.

1 reference

12 December 2020

The dawning era of polymer therapeutics

1 reference

12 December 2020

Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications

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12 December 2020

Controlled delivery of biotechnological products

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12 December 2020

Counterintuitive red blood cell substitute--polyethylene glycol-modified human hemoglobin.

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12 December 2020

Camptothecin antitumor agents

1 reference

12 December 2020

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand

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12 December 2020

Oral delivery of peptide drugs: barriers and developments.

1 reference

12 December 2020

Hypouricaemic effect of polyethyleneglycol modified urate oxidase

1 reference

12 December 2020

Polymer architecture and drug delivery

1 reference

12 December 2020

The enzyme as drug: application of enzymes as pharmaceuticals

1 reference

12 December 2020

Fully human therapeutic monoclonal antibodies

1 reference

12 December 2020

Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

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12 December 2020

Some properties of polyethylene glycol:phenylalanine ammonia-lyase adducts

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12 December 2020

Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice

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12 December 2020

Human lung carcinomas express Fas ligand.

1 reference

12 December 2020

Pegylated interferon alfa-2b treatment for patients with solid tumors: a phase I/II study.

1 reference

12 December 2020

Cell-specific delivery of genes with glycosylated carriers

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12 December 2020

Disposition and tumor localization of mitomycin C-dextran conjugates in mice

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12 December 2020

The uses and properties of PEG-linked proteins

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12 December 2020

Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo.

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12 December 2020

Cancer/testis tumour-associated antigens: immunohistochemical detection with monoclonal antibodies

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12 December 2020

Activation-induced cell death: the controversial role of Fas and Fas ligand in immune privilege and tumour counterattack

1 reference

12 December 2020

Clinical pharmacology of polyethylene glycol-L-asparaginase

1 reference

12 December 2020

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase

1 reference

12 December 2020

The impact of nanobiotechnology on the development of new drug delivery systems.

1 reference

12 December 2020

A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin

1 reference

12 December 2020

Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate

1 reference

12 December 2020

Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo

1 reference

12 December 2020

Long-acting growth hormones produced by conjugation with polyethylene glycol.

1 reference

12 December 2020

Preparation and properties of monomethoxy poly(ethylene glycol) doxorubicin conjugates linked by an amino acid or a peptide as spacer

1 reference

12 December 2020

Dendritic cells prevent CD95 mediated T lymphocyte death through costimulatory signals

1 reference

12 December 2020

Chemical modification of recombinant human granulocyte colony-stimulating factor by polyethylene glycol increases its biological activity in vivo

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12 December 2020

A branched monomethoxypoly(ethylene glycol) for protein modification

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12 December 2020

Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape

1 reference

12 December 2020

Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis

1 reference

12 December 2020

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

1 reference

12 December 2020

Polymer-protein and polymer-drug conjugates in cancer therapy

1 reference

12 December 2020

Bioconjugation in pharmaceutical chemistry.

1 reference

12 December 2020

Drug delivery and targeting

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12 December 2020

Recent advances with liposomes as pharmaceutical carriers

1 reference

12 December 2020

Drug targeting with nano-sized carrier systems

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12 December 2020

HPMA copolymers platinates containing dicarboxylato ligands. Preparation, characterisation and in vitro and in vivo evaluation

1 reference

12 December 2020

The next frontier of molecular medicine: delivery of therapeutics.

1 reference

12 December 2020

Prostate-Specific Antigen and the Early Diagnosis of Prostate Cancer

1 reference

12 December 2020

Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol

1 reference

12 December 2020

Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats

1 reference

12 December 2020

Clinical relevance of the molecular mechanisms of resistance to anti-cancer drugs

1 reference

12 December 2020

Vascular targeting agents as cancer therapeutics

1 reference

12 December 2020

Characterization of oligodeoxyribonucleotide-polyethylene glycol conjugates by electrospray mass spectrometry

1 reference

12 December 2020

Accurate evaluation method of the polymer content in monomethoxy(polyethylene glycol) modified proteins based on amino acid analysis

1 reference

12 December 2020

Effective cancer targeting using an anti-tumor tissue vascular endothelium-specific monoclonal antibody (TES-23).

1 reference

12 December 2020

Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of functional Fas ligand

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12 December 2020

Clinical use of pegvisomant for the treatment of acromegaly

1 reference

12 December 2020

A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease

1 reference

12 December 2020

Oligonucleotides as research, diagnostic, and therapeutic agents

1 reference

12 December 2020

Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies

1 reference

12 December 2020

Endoglin (CD105): a target for anti-angiogenetic cancer therapy

1 reference

12 December 2020

Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications

1 reference

12 December 2020

Modeling of drug release from polymeric delivery systems--a review

1 reference

12 December 2020

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

1 reference

12 December 2020

Enhanced delivery improves the efficacy of a tumor-specific doxorubicin immunoconjugate in a human brain tumor xenograft model.

1 reference

12 December 2020

Ligand-targeted therapeutics in anticancer therapy

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12 December 2020

Peptide and protein PEGylation: a review of problems and solutions

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12 December 2020

New form of paclitaxel shows promise

1 reference

12 December 2020

Polymer conjugates: nanosized medicines for treating cancer

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12 December 2020

Pegylation: a novel process for modifying pharmacokinetics

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12 December 2020

Biodegradable long-circulating polymeric nanospheres

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12 December 2020

Stability, specific binding activity, and plasma concentration in mice of an oligodeoxynucleotide modified at 5'-terminal with poly(ethylene glycol).

1 reference

12 December 2020

Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease.

1 reference

12 December 2020

Polymer-coated long-circulating microparticulate pharmaceuticals

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12 December 2020

Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention

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12 December 2020

Microbial degradation of polyethers

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12 December 2020

Macromolecular therapeutics: advantages and prospects with special emphasis on solid tumour targeting

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12 December 2020

Polymeric controlled drug-delivery systems: perspective issues and opportunities.

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12 December 2020

Use of peginterferon alfa-2a (40 KD) (Pegasys) for the treatment of hepatitis C.

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12 December 2020

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12 December 2020

Effect of polyethylene glycol conjugated bovine hemoglobin in both top-load and exchange transfusion rat models

1 reference

12 December 2020

Synthesis and properties of oligodeoxyribonucleotide-polyethylene glycol conjugates

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12 December 2020

Factors and mechanism of "EPR" effect and the enhanced antitumor effects of macromolecular drugs including SMANCS.

1 reference

12 December 2020

Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase

1 reference

12 December 2020

Nanomedicine transforms drug delivery

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12 December 2020

Cytotoxic drugs and the CD95 pathway

1 reference

12 December 2020

Pharmacokinetic properties of polyethylene glycol derivatized superoxide dismutase

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12 December 2020

Targeted chemotherapy in mice with peritoneally disseminated gastric cancer using monoclonal antibody-drug conjugate

1 reference

12 December 2020

Tumor Vasculature Targeted Therapies

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12 December 2020

Novel effects with polyethylene glycol modified pharmaceuticals

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12 December 2020

Clinical review 166: Growth hormone receptor antagonists

1 reference

12 December 2020

Drug delivery in biotechnology: present and future.

1 reference

12 December 2020

Pegylated interferon-alpha2b: pharmacokinetics, pharmacodynamics, safety, and preliminary efficacy data. Hepatitis C Intervention Therapy Group

1 reference

12 December 2020

A new procedure for the synthesis of polyethylene glycol-protein adducts; Effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and α2-macroglobulin

1 reference

12 December 2020

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment

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12 December 2020

Targeted drug delivery in cancer therapy

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12 December 2020

Drug-targeting strategies in cancer therapy

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12 December 2020

Glucocerebrosidase (Gaucher disease).

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12 December 2020

Ability of serum prostate-specific antigen levels to predict normal bone scans in patients with newly diagnosed prostate cancer

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12 December 2020

Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates

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12 December 2020

Essential properties of drug-targeting delivery systems

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12 December 2020

The anti-gene strategy: control of gene expression by triplex-forming-oligonucleotides

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12 December 2020

Enzymatic procedure for site-specific pegylation of proteins

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12 December 2020

Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration

1 reference

12 December 2020

Pegaptanib for wet macular degeneration

1 reference

12 December 2020

Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back

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12 December 2020

Nanomedicine: current status and future prospects.

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12 December 2020

Drug delivery systems: water soluble taxol 2'-poly(ethylene glycol) ester prodrugs-design and in vivo effectiveness

1 reference

12 December 2020

Commercial challenges of protein drug delivery

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12 December 2020

Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin

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12 December 2020

Treatment of pituitary tumors: pegvisomant

1 reference

12 December 2020

10.2165/00003088-200645100-00002

Identifiers

DOI

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Dimensions Publication ID

15 August 2017

1045704688

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