(Q36600282)

15 August 2017

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title

Novel anticonvulsant drugs targeting voltage-dependent ion channels (English)

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15 August 2017

Thomas V Wuttke

1

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15 August 2017

Holger Lerche

series ordinal

2

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15 August 2017

language of work or name

English

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publication date

1 October 2006

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Expert Opinion on Investigational Drugs

15 August 2017

published in

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15 August 2017

volume

15

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15 August 2017

issue

10

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15 August 2017

page(s)

1167-1177

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Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota

15 August 2017

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Prevalence of epilepsy in Rochester, Minnesota: 1940-1980.

21 January 2018

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Seizure reduction and quality of life improvements in people with epilepsy

21 January 2018

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Genes and mutations in human idiopathic epilepsy

21 January 2018

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Ion channel defects in idiopathic epilepsies

21 January 2018

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The importance of drug interactions in epilepsy therapy

21 January 2018

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X-ray structure of a voltage-dependent K+ channel

21 January 2018

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Determination of the subunit stoichiometry of a voltage-activated potassium channel

21 January 2018

1 reference

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The open pore conformation of potassium channels

21 January 2018

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Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture.

21 January 2018

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Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.

21 January 2018

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Valproic acid inhibits the depolarizing rectification in neurons of rat amygdala.

21 January 2018

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The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel

21 January 2018

1 reference

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Preferential action of gabapentin and pregabalin at P/Q-type voltage-sensitive calcium channels: inhibition of K+-evoked [3H]-norepinephrine release from rat neocortical slices

21 January 2018

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D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.

21 January 2018

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Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex hippocampal slices.

21 January 2018

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The anticonvulsant retigabine potently suppresses epileptiform discharges in the low Ca ++ and low Mg++ model in the hippocampal slice preparation.

21 January 2018

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Effects of retigabine on rhythmic synchronous activity of human neocortical slices

21 January 2018

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The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate

21 January 2018

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Effects of the anticonvulsant retigabine on cultured cortical neurons: changes in electroresponsive properties and synaptic transmission

21 January 2018

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Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties

21 January 2018

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Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels

21 January 2018

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Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels

21 January 2018

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BMS-204352: a potassium channel opener developed for the treatment of stroke

21 January 2018

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Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder

21 January 2018

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Synthesis and anticonvulsant activity of a new class of 2-[(arylalky)amino]alkanamide derivatives

21 January 2018

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Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy

21 January 2018

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Levetiracetam does not modulate neuronal voltage-gated Na+ and T-type Ca2+ currents

21 January 2018

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Levetiracetam opposes the action of GABAA antagonists in hypothalamic neurones

21 January 2018

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Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity

21 January 2018

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Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures

21 January 2018

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Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex

21 January 2018

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Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI).

21 January 2018

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Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat.

21 January 2018

1 reference

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The biology and pharmacology of calcium channel alpha2-delta proteins Pfizer Satellite Symposium to the 2003 Society for Neuroscience Meeting. Sheraton New Orleans Hotel, New Orleans, LA November 10, 2003.

21 January 2018

1 reference

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Gabapentin inhibits the substance P-facilitated K(+)-evoked release of [(3)H]glutamate from rat caudial trigeminal nucleus slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.10.1167

Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.10.1167

Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.10.1167

Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms

21 January 2018

1 reference

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10.1517/13543784.15.10.1167

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference