(Q36609881)

English

Small Molecule Sequential Dual-Targeting Theragnostic Strategy (SMSDTTS): from Preclinical Experiments towards Possible Clinical Anticancer Applications

scientific article published on 22 January 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Small Molecule Sequential Dual-Targeting Theragnostic Strategy (SMSDTTS): from Preclinical Experiments towards Possible Clinical Anticancer Applications (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Junjie Li

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Raymond Oyen

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Alfons Verbruggen

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Yicheng Ni

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

publication date

22 January 2013

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

133-145

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts

1 reference

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Diverse responses to vascular disrupting agent combretastatin a4 phosphate: a comparative study in rats with hepatic and subcutaneous tumor allografts using MRI biomarkers, microangiography, and histopathology

1 reference

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Exploring theranostic potentials of radioiodinated hypericin in rodent necrosis models

1 reference

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A single-dose toxicity study on non-radioactive iodinated hypericin for a targeted anticancer therapy in mice

1 reference

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Nanoparticle-assisted combination therapies for effective cancer treatment.

1 reference

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Enhanced antitumor efficacy of a vascular disrupting agent combined with an antiangiogenic in a rat liver tumor model evaluated by multiparametric MRI

1 reference

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30 September 2017

A review on various targeted anticancer therapies

1 reference

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Transbilayer phospholipids molecular imaging.

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Continuing pursuit for ideal systemic anticancer radiotherapeutics

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Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors

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MRI & MRS assessment of the role of the tumour microenvironment in response to therapy.

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A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment

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Multiparametric MRI biomarkers for measuring vascular disrupting effect on cancer

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Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer.

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30 September 2017

Combretastatin A4 Phosphate: A Novel Vascular Disrupting Agent

1 reference

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Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA.

1 reference

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The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents

1 reference

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30 September 2017

A Phase Ib trial of CA4P (combretastatin A-4 phosphate), carboplatin, and paclitaxel in patients with advanced cancer

1 reference

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Hypericins as potential leads for new therapeutics

1 reference

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Metastasis mechanisms

1 reference

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Models for prevention and treatment of cancer: problems vs promises

1 reference

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Nitric oxide synthase inhibition enhances the tumor vascular-damaging effects of combretastatin a-4 3-o-phosphate at clinically relevant doses

1 reference

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30 September 2017

Vessel growth and function: depiction with contrast-enhanced MR imaging.

1 reference

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30 September 2017

Molecular imaging of cell death

1 reference

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Novel agents on the horizon for cancer therapy

1 reference

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Engineered nanoparticles in cancer therapy

1 reference

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30 September 2017

Tumour vascular disrupting agents: combating treatment resistance

1 reference

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Vascular targeted therapies in oncology

1 reference

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Dual targeting of tumor vasculature: combining Avastin and vascular disrupting agents (CA4P or OXi4503).

1 reference

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Expansion and evolution of cell death programmes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Exploration of the mechanism underlying the tumor necrosis avidity of hypericin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Characterizing the tumor response to treatment with combretastatin A4 phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Visualizing the acute effects of vascular-targeted therapy in vivo using intravital microscopy and magnetic resonance imaging: correlation with endothelial apoptosis, cytokine induction, and treatment outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Drug insight: vascular disrupting agents and angiogenesis--novel approaches for drug delivery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

131I activity for remnant ablation in patients with differentiated thyroid cancer: A systematic review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Rat tumor response to the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid as measured by dynamic contrast-enhanced magnetic resonance imaging, plasma 5-hydroxyindoleacetic acid levels, and tumor necrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

CTL adoptive immunotherapy concurrently mediates tumor regression and tumor escape

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Understanding microtubule dynamics for improved cancer therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Necrosis avid contrast agents: functional similarity versus structural diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Disrupting tumour blood vessels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Overview of monoclonal antibodies in cancer therapy: present and promise

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Phase I trial of combretastatin a-4 phosphate with carboplatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Novel vascular targeting/disrupting agents: combretastatin A4 phosphate and related compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Cardiovascular safety profile of combretastatin a4 phosphate in a single-dose phase I study in patients with advanced cancer

1 reference

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30 September 2017

Therapy with radiopharmaceuticals

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30 September 2017

Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results

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30 September 2017

Non-invasive in vivo imaging of myocardial apoptosis and necrosis

1 reference

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30 September 2017

Specialization of tumour vasculature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Antivascular tumor eradication by hypericin-mediated photodynamic therapy

1 reference

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30 September 2017

Chemo-radionuclide therapy for thyroid cancer: initial experimental study with cultured cells

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30 September 2017

Hypericin in cancer treatment: more light on the way.

1 reference

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30 September 2017

Actinobacillus actinomycetemcomitans leukotoxin induces apoptosis in HL-60 cells

1 reference

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30 September 2017

Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Magnetic resonance imaging-histomorphologic correlation studies on paramagnetic metalloporphyrins in rat models of necrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

Differential cytotoxic effects induced after photosensitization by hypericin.

1 reference

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30 September 2017

Patterns of cell death.

1 reference

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30 September 2017

Angiogenic attack as a therapeutic strategy for cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

30 September 2017

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1 reference

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30 September 2017

Radiotoxicity of some iodine-123, iodine-125 and iodine-131-labeled compounds in mouse testes: implications for radiopharmaceutical design

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30 September 2017

Technetium-99m-pyrophosphate: studies in vivo and in vitro

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30 September 2017

A novel method for the detection of necrotic lesions in human cancers.

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30 September 2017

Subcellular distributions and excited-state processes of hypericin in neurons

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

28 June 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

28 June 2018

Oxygen dependence of hypericin-induced phototoxicity to EMT6 mouse mammary carcinoma cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

28 June 2018

Magnetic resonance imaging, microangiography, and histology in a rat model of primary liver cancer

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28 June 2018

The prognostic implications of acute myocardial infarct scintigraphy with 99mTc-pyrophosphate

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28 June 2018

A safety study on single intravenous dose of tetrachloro-diphenyl glycoluril [iodogen] dissolved in dimethyl sulphoxide (DMSO).

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20 September 2018

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20 September 2018

Combination of combretastatin A4 phosphate and doxorubicin-containing liposomes affects growth of B16-F10 tumors.

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20 September 2018

Guideline to regulations for radiopharmaceuticals in early phase clinical trials in the EU.

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20 September 2018

Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model.

1 reference

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20 September 2018

Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT.

1 reference

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20 September 2018

Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model.

1 reference

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20 September 2018

(131)I-chTNT-1/B mAb: tumour necrosis therapy for malignant astrocytic glioma

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20 September 2018

Differentiated thyroid cancer: comparison of therapeutic iodine 131 biological elimination after discontinuation of levothyroxine versus administration of recombinant human thyrotropin.

1 reference

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20 September 2018

First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent

1 reference

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20 September 2018

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20 September 2018

A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer.

1 reference

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20 September 2018

Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.

1 reference

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20 September 2018

Intracoronary delivery of Gd-DTPA and Gadophrin-2 for determination of myocardial viability with MR imaging

1 reference

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20 September 2018

Photodynamic therapy with hypericin in a mouse P388 tumor model: vascular effects determine the efficacy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572405

20 September 2018

Radiolabeled iodohypericin as tumor necrosis avid tracer: diagnostic and therapeutic potential

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4 December 2018

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1 reference

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4 December 2018

Phase Ib trial of radiotherapy in combination with combretastatin-A4-phosphate in patients with non-small-cell lung cancer, prostate adenocarcinoma, and squamous cell carcinoma of the head and neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of metalloporphyrin-induced "specific" enhancement in experimental liver tumors: comparison of magnetic resonance imaging, microangiographic, and histologic findings

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular targeting as a strategy for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis treatment of ME-180 human cervical carcinoma model with 131I-labeled TNT-1 monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding, uptake, and transport of hypericin by Caco-2 cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MRI contrast enhancement of necrosis by MP-2269 and gadophrin-2 in a rat model of liver infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiotoxicity after iodine-131 therapy for thyroid cancer using the micronucleus assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimyosin-labeled monocrystalline iron oxide allows detection of myocardial infarct: MR antibody imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioimmunotherapy of cancer: arming the missiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and preliminary evaluation of mono-[123I]iodohypericin monocarboxylic acid as a necrosis avid imaging agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23412554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.7150/JCA.5635

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

release_ckrzlvzulna5zmkyptmtbh5ama

1 reference

https://api.fatcat.wiki/v0/release/ckrzlvzulna5zmkyptmtbh5ama

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

ResearchGate publication ID

0 references

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