(Q34535031)

2 August 2017

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title

Hypericin in cancer treatment: more light on the way. (English)

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2 August 2017

Patrizia Agostinis

1

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author name string

Annelies Vantieghem

series ordinal

2

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2 August 2017

Wilfried Merlevede

series ordinal

3

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2 August 2017

Peter A M de Witte

series ordinal

4

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2 August 2017

language of work or name

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1 March 2002

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International Journal of Biochemistry & Cell Biology

2 August 2017

published in

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2 August 2017

volume

34

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2 August 2017

issue

3

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2 August 2017

page(s)

221-241

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Hypericin and pseudohypericin in some Hypericum species

2 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

The chemical and biological properties of hypericin--a compound with a broad spectrum of biological activities

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

On the nature of ?soluble? hypericin inHypericum species

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Seasonal variation in hypericin content of Hypericum perforatum L. (St. John's Wort).

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photocytotoxicity of Protohypericin after Photoconversion to Hypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John's wort)

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

St John's wort for depression--an overview and meta-analysis of randomised clinical trials

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Comparison of St John's wort and imipramine for treating depression: randomised controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hyperforin as a possible antidepressant component of hypericum extracts

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

A compilation of singlet oxygen yields from biologically relevant molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's wort plant, in patients with chronic hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Antiretroviral activity of synthetic hypericin and related analogs

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Antiviral activity of the photoactive plant pigment hypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Chemiluminescent activation of the antiviral activity of hypericin: a molecular flashlight

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Antiviral activities of hypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

The importance of light in the anti-HIV effect of hypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin as an inactivator of infectious viruses in blood components.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Inhibition of duck hepatitis B virus replication by hypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

1 reference

7 January 2021

Cylindrical fiberoptic light diffuser for medical applications

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photodynamic therapy in oncology: mechanisms and clinical use.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

What does photodynamic therapy have to offer radiation oncologists (or their cancer patients)?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photosensitized inhibition of growth factor-regulated protein kinases by hypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

The effect of hypericin and hypocrellin-A on lipid membranes and membrane potential of 3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photoactivation of hypericin generates singlet oxygen in mitochondria and inhibits succinoxidase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Effect of the antiretroviral agent hypericin on rat liver mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Different pathways mediate cytochrome c release after photodynamic therapy with hypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photooxidation of lens alpha-crystallin by hypericin (active ingredient in St. John's Wort).

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Oxygen dependence of hypericin-induced phototoxicity to EMT6 mouse mammary carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photosensitization with anticancer agents. 17. EPR studies of photodynamic action of hypericin: formation of semiquinone radical and activated oxygen species on illumination

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photodynamically induced cytotoxicity of hypericin dye on human fibroblast cell line MRC5.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Laser photosensitization of cells by hypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin: a potential antiglioma therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Effects of anthralin and hypericin on growth factor signalling and cell proliferation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin-induced phototoxicity in cultured fibroblasts and swine erythrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin: a new laser phototargeting agent for human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Differential cytotoxic effects induced after photosensitization by hypericin.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photoactivated hypericin is an anti-proliferative agent that induces a high rate of apoptotic death of normal, transformed, and malignant T lymphocytes: implications for the treatment of cutaneous lymphoproliferative and inflammatory disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Antioxidant enzyme response to hypericin in EMT6 mouse mammary carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin photosensitization of tumor and metastatic cell lines of human prostate

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photocytotoxicity of hypericin in normoxic and hypoxic conditions

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

The role of oxygen in the antiviral activity of hypericin and hypocrellin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photophysics of hypericin and hypocrellin A in complex with subcellular components: interactions with human serum albumin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Is the excited-state H-atom transfer in hypericin concerted?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Subcellular distributions and excited-state processes of hypericin in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Binding, uptake, and transport of hypericin by Caco-2 cell monolayers

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Sequence Specific Interaction of the Antiretrovirally Active Drug Hypericin with 5′ATGGCAGGATAT3′ Oligonucleotide: A Resonance Raman Spectroscopy Study

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Sequence Specific Interaction of the Photoactive Drug Hypericin Depends on the Structural Arrangement and the Stability of the Structure Containing its Specific 5′AG3′ Target: A Resonance Raman Spectroscopy Study

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

More than one way to die: apoptosis, necrosis and reactive oxygen damage

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Mechanisms and Functions of Cell Death

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin inhibits cell growth and induces apoptosis in retinal pigment epithelial cells: possible involvement of protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Growth inhibition and apoptosis in human neuroblastoma SK-N-SH cells induced by hypericin, a potent inhibitor of protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Cellular photodestruction induced by hypericin in AY-27 rat bladder carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Over-expression of Bcl-2 does not protect cells from hypericin photo-induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Chlamydia pneumoniae inhibits apoptosis in human peripheral blood mononuclear cells through induction of IL-10.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

The role of subcellular localization in initiation of apoptosis by photodynamic therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Signaling pathways in cell death and survival after photodynamic therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

A photodynamic pathway to apoptosis and necrosis induced by dimethyl tetrahydroxyhelianthrone and hypericin in leukaemic cells: possible relevance to photodynamic therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Bcl-2 family proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Apoptosis control by death and decoy receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

All along the watchtower: on the regulation of apoptosis regulators.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photodynamic therapy: a mitochondrial inducer of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

IAP family proteins--suppressors of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Target protease specificity of the viral serpin CrmA. Analysis of five caspases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photodynamic therapy induces caspase-3 activation in HL-60 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photodynamic therapy-induced apoptosis in lymphoma cells: translocation of cytochrome c causes inhibition of respiration as well as caspase activation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photodynamic therapy-induced death of MCF-7 human breast cancer cells: a role for caspase-3 in the late steps of apoptosis but not for the critical lethal event

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Involvement of Fas (APO-1/CD-95) during photodynamic-therapy-mediated apoptosis in human epidermoid carcinoma A431 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Mitochondrial control of cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Involvement of Bcl-2 and Bax in photodynamic therapy-mediated apoptosis. Antisense Bcl-2 oligonucleotide sensitizes RIF 1 cells to photodynamic therapy apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photochemical destruction of the Bcl-2 oncoprotein during photodynamic therapy with the phthalocyanine photosensitizer Pc 4.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Signal transduction through MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Promotion of photodynamic therapy-induced apoptosis by stress kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Stimulation of stress-activated protein kinase and p38 HOG1 kinase in murine keratinocytes following photodynamic therapy with benzoporphyrin derivative

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Apoptotic signalling cascade in photosensitized human epidermal carcinoma A431 cells: involvement of singlet oxygen, c-Jun N-terminal kinase, caspase-3 and p21-activated kinase 2.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Activation of p38 mitogen-activated protein kinase is required for tumor necrosis factor-alpha -supported proliferation of leukemia and lymphoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Photodynamic therapy efficacy and tissue distribution of hypericin in a mouse P388 lymphoma tumor model

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin and photodynamic therapy decreases human pancreatic cancer in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Intratumoral hypericin and KTP laser therapy for transplanted squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

The antidepressant hypericin inhibits progression of experimental proliferative vitreoretinopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

A comparative analysis of silicon phthalocyanine photosensitizers for in vivo photodynamic therapy of RIF-1 tumors in C3H mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Does tumour uptake of Foscan determine PDT efficacy?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Hypericin in phototherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Inhibition of the CD8+ T cell-mediated cytotoxicity reaction by hypericin: potential for treatment of T cell-mediated diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

Role of adhesion molecules in bladder cancer: an important part of the jigsaw

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2801%2900126-1

7 January 2021

10.1016/S1357-2725(01)00126-1

Identifiers

DOI

1 reference

2 August 2017

1 reference