(Q36610404)

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Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer

scientific article published on August 2006

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scholarly article

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Europe PubMed Central

15 August 2017

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Europe PubMed Central

Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer (English)

1 reference

Europe PubMed Central

15 August 2017

Regina Brigelius-Flohé

1

object named as

Regina Brigelius-Flohé

1 reference

Europe PubMed Central

15 August 2017

author name string

Antje Banning

2

1 reference

Europe PubMed Central

15 August 2017

publication date

1 August 2006

1 reference

Europe PubMed Central

15 August 2017

Free Radical Research

1 reference

Europe PubMed Central

15 August 2017

40

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Europe PubMed Central

15 August 2017

8

1 reference

Europe PubMed Central

15 August 2017

775-787

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Europe PubMed Central

15 August 2017

Global cancer statistics in the year 2000.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Consumption of vegetables and fruits and risk of breast cancer

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Risk of bladder cancer by geographic region in a U.S. cohort of male health professionals

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Selenium in cancer prevention: a review of the evidence and mechanism of action

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Sulforaphane, erucin, and iberin up-regulate thioredoxin reductase 1 expression in human MCF-7 cells

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

The GI-GPx gene is a target for Nrf2

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Rape-seed meal toxicity in gnotobiotic rats: influence of a whole human faecal flora or single human strains of Escherichia coli and Bacteroides vulgatus.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NF-kappaB binding to DNA.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Induction of phase I, II and III drug metabolism/transport by xenobiotics

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Nrf2 as a novel molecular target for chemoprevention

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Transport between the cell nucleus and the cytoplasm

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Nuclear import and export signals in control of Nrf2.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Dietary chemopreventive compounds and ARE/EpRE signaling.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

PTPs versus PTKs: the redox side of the coin

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Regulation of protein function by glutathionylation

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Post-translational disulfide modifications in cell signaling--role of inter-protein, intra-protein, S-glutathionyl, and S-cysteaminyl disulfide modifications in signal transmission

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

How selenium has altered our understanding of the genetic code

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Characterization of mammalian selenoproteomes.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Tissue-specific functions of individual glutathione peroxidases

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Selenium in biology: facts and medical perspectives

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

An analysis of cancer prevention by selenium

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

The thioredoxin system—From science to clinic

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survival.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Increased levels of cytosolic thioredoxin reductase activity and mRNA in rat liver nodules

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Thioredoxin reductase as a pathophysiological factor and drug target

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Thioredoxin reductase regulates angiogenesis by increasing endothelial cell-derived vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Induction of thioredoxin reductase as an adaptive response to acrolein in human umbilical vein endothelial cells

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Expression of gastrointestinal glutathione peroxidase is inversely correlated to the presence of hepatitis C virus subgenomic RNA in human liver cells.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Gene expression profiling of NRF2-mediated protection against oxidative injury

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Inflammation and cancer: back to Virchow?

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

NF-kappaB functions as a tumour promoter in inflammation-associated cancer

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Cultivation conditions and selenium fertilization alter the phenolic profile, glucosinolate, and sulforaphane content of broccoli

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

On the nature of selenium toxicity and carcinostatic activity

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Chemical and molecular regulation of enzymes that detoxify carcinogens

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Identification of a second region upstream of the mouse heme oxygenase-1 gene that functions as a basal level and inducer-dependent transcription enhancer

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Electrophile and antioxidant regulation of enzymes that detoxify carcinogens

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Identification of dithiolethione-inducible gene-1 as a leukotriene B4 12-hydroxydehydrogenase: implications for chemoprevention.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2)

1 reference

https://api.crossref.org/works/10.1080%2F10715760600722643

21 January 2018

Identifiers

10.1080/10715760600722643

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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