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Control of telomerase action at human telomeres
scientific article published on November 2015
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Europe PubMed Central
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4765361
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581518%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
title
Control of telomerase action at human telomeres
(English)
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Europe PubMed Central
PMCID
4765361
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581518%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
author
Dirk Hockemeyer
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1
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Europe PubMed Central
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4765361
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581518%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
author name string
Kathleen Collins
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2
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4765361
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29 February 2020
publication date
1 November 2015
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29 February 2020
published in
Nature Structural & Molecular Biology
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Europe PubMed Central
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4765361
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29 February 2020
volume
22
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4765361
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29 February 2020
page(s)
848-852
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Europe PubMed Central
PMCID
4765361
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581518%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
issue
11
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Europe PubMed Central
PMCID
4765361
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581518%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
exact match
https://scigraph.springernature.com/pub.10.1038/nsmb.3083
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Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance
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Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation
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Inhibition of telomerase recruitment and cancer cell death
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TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends
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The human CST complex is a terminator of telomerase activity
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Telomerase recruitment requires both TCAB1 and Cajal bodies independently
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An enhanced H/ACA RNP assembly mechanism for human telomerase RNA
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The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection
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It all comes together at the ends: telomerase structure, function, and biogenesis
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30 September 2017
A role for heterochromatin protein 1γ at human telomeres
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Architecture of human telomerase RNA.
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Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita
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Evolution of CST function in telomere maintenance
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A Cajal body-independent pathway for telomerase trafficking in mice
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TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
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A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
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TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes
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30 September 2017
TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita
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Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
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30 September 2017
Physiological assembly and activity of human telomerase complexes
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30 September 2017
Telomerase RNA levels limit the telomere length equilibrium
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30 September 2017
The POT1-TPP1 telomere complex is a telomerase processivity factor
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30 September 2017
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
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30 September 2017
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
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30 September 2017
Telomere length homeostasis
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30 September 2017
Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase
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30 September 2017
The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair
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30 September 2017
Stepwise RNP assembly at the site of H/ACA RNA transcription in human cells
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30 September 2017
Telomere length homeostasis requires that telomerase levels are limiting
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30 September 2017
Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans.
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30 September 2017
Cell cycle-regulated trafficking of human telomerase to telomeres
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30 September 2017
Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres
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30 September 2017
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
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30 September 2017
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30 September 2017
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30 September 2017
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
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30 September 2017
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex
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30 September 2017
Regulation of telomerase by telomeric proteins
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30 September 2017
Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function
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30 September 2017
A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs.
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30 September 2017
POT1 as a terminal transducer of TRF1 telomere length control
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30 September 2017
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2
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30 September 2017
A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4765361
retrieved
30 September 2017
Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4765361
retrieved
30 September 2017
Control of human telomere length by TRF1 and TRF2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4765361
retrieved
30 September 2017
Mammalian telomeres end in a large duplex loop
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4765361
retrieved
30 September 2017
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4765361
retrieved
30 September 2017
Lack of cell cycle regulation of telomerase activity in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4765361
retrieved
30 September 2017
Control of telomere length by the human telomeric protein TRF1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4765361
retrieved
30 September 2017
TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4765361
retrieved
28 June 2018
Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4765361
retrieved
28 June 2018
Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4765361
retrieved
20 September 2018
Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4765361
retrieved
20 September 2018
Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNSMB.3083
retrieved
31 March 2020
Identifiers
DOI
10.1038/NSMB.3083
1 reference
stated in
Europe PubMed Central
PMCID
4765361
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581518%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
PMCID
4765361
1 reference
stated in
Europe PubMed Central
PMCID
4765361
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581518%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
PubMed ID
26581518
1 reference
stated in
Europe PubMed Central
PMCID
4765361
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26581518%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
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