(Q36621492)

English

Phase I clinical trial with IL-2-transfected xenogeneic cells administered in subcutaneous metastatic tumours: clinical and immunological findings

scientific article published on December 2000

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scholarly article

1 reference

Europe PubMed Central

15 August 2017

Phase I clinical trial with IL-2-transfected xenogeneic cells administered in subcutaneous metastatic tumours: clinical and immunological findings (English)

1 reference

Europe PubMed Central

15 August 2017

phase I clinical trial

0 references

Xavier Sastre-Garau

3

object named as

Sastre-Garau X

1 reference

Europe PubMed Central

15 August 2017

author name string

Tartour E

1

1 reference

Europe PubMed Central

15 August 2017

Mehtali M

2

1 reference

Europe PubMed Central

15 August 2017

Joyeux I

4

1 reference

Europe PubMed Central

15 August 2017

Mathiot C

5

1 reference

Europe PubMed Central

15 August 2017

Pleau JM

6

1 reference

Europe PubMed Central

15 August 2017

Squiban P

7

1 reference

Europe PubMed Central

15 August 2017

Rochlitz C

8

1 reference

Europe PubMed Central

15 August 2017

Courtney M

9

1 reference

Europe PubMed Central

15 August 2017

Jantscheff P

10

1 reference

Europe PubMed Central

15 August 2017

Herrmann R

11

1 reference

Europe PubMed Central

15 August 2017

Pouillart P

12

1 reference

Europe PubMed Central

15 August 2017

Fridman WH

13

1 reference

Europe PubMed Central

15 August 2017

Dorval T

14

1 reference

Europe PubMed Central

15 August 2017

language of work or name

0 references

publication date

1 December 2000

1 reference

Europe PubMed Central

15 August 2017

British Journal of Cancer

1 reference

Europe PubMed Central

15 August 2017

83

1 reference

Europe PubMed Central

15 August 2017

11

1 reference

Europe PubMed Central

15 August 2017

1454-1461

1 reference

Europe PubMed Central

15 August 2017

https://scigraph.springernature.com/pub.10.1054/bjoc.2000.1492

0 references

Gene therapy study of cytokine-transfected xenogeneic cells (Vero-interleukin-2) in patients with metastatic solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Interleukin-2 gene-modified allogeneic tumor cells for treatment of relapsed neuroblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

In vivo tumor transfection with superantigen plus cytokine genes induces tumor regression and prolongs survival in dogs with malignant melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Inhibition of established pancreatic cancers following specific active immunotherapy with interleukin-2 gene-transduced tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

A phase-I clinical study of autologous tumor cells plus interleukin-2-gene-transfected allogeneic fibroblasts as a vaccine in patients with cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Immunotherapy of malignancy by in vivo gene transfer into tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Controlled release, biodegradable cytokine depots: a new approach in cancer vaccine design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Signals and signs for lymphocyte responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Priming of tumor-specific T cells in the draining lymph nodes after immunization with interleukin 2-secreting tumor cells: three consecutive stages may be required for successful tumor vaccination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Immunobiology and immunotherapy of melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Cytokines and gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Paracrine cytokine adjuvants in cancer immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Viral oncolysis: increased immunogenicity of host cell antigen associated with influenza virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Current status of interleukin-2 therapy in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

30 September 2017

Cytokines and cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Immunological ignorance of silent antigens as an explanation of tumor evasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

The host-tumor immune conflict: from immunosuppression to resistance and destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Reduced efficacy of allogeneic versus syngeneic fibroblasts modified to secrete cytokines as a tumor vaccine adjuvant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Adenoviral interleukin-2 gene transfer into P815 tumor cells abrogates tumorigenicity and induces antitumoral immunity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Induction in a murine tumor of immunogenic tumor variants by transfection with a foreign gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Circulating cytokines in patients with metastatic cancer treated with recombinant interleukin 2 and lymphokine-activated killer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Murine interleukin-4 displays potent anti-tumor activity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Inhibition of tumor growth by histoincompatible cells expressing interleukin-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

28 June 2018

Sustained cytokine delivery for anticancer vaccination: liposomes as alternative for gene-transfected tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

20 September 2018

Intracerebral versus subcutaneous immunization with allogeneic fibroblasts genetically engineered to secrete interleukin-2 in the treatment of central nervous system glioma and melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

20 September 2018

Gene therapy of spontaneous canine melanoma and feline fibrosarcoma by intratumoral administration of histoincompatible cells expressing human interleukin-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

20 September 2018

Induction of antitumor immunity by interleukin-2 gene-transduced mouse mammary tumor cells versus transduced mammary stromal fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

20 September 2018

In vivo delivery of interleukin-4 by a recombinant vaccinia virus prevents tumor development in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

20 September 2018

Complete recovery of mice from a pre-established tumor by direct intratumoral delivery of an adenovirus vector harboring the murine IL-2 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

20 September 2018

Cytokine Gene Therapy with Interleukin-2-Transduced Fibroblasts: Effects of IL-2 Dose on Anti-Tumor Immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

20 September 2018

Pharmacokinetics of recombinant interleukin 2 in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

20 September 2018

Elicitation of a systemic and protective anti-melanoma immune response by an IL-2-based vaccine. Assessment of critical cellular and molecular parameters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

21 October 2018

IL-2 phase II trial in metastatic melanoma: analysis of clinical and immunological parameters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363414

21 October 2018

Immunotherapy of metastatic melanoma with interferon-alpha and interleukin-2: pattern of progression in responders and patients with stable disease with or without resection of residual lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Th2 cytokine mRNA expression in skin in cutaneous T-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic antitumor effects of electrochemotherapy combined with histoincompatible cells secreting interleukin-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cells infiltrating non-Hodgkin's B cell lymphomas show altered tyrosine phosphorylation pattern even though T cell receptor/CD3-associated kinases are present

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gradual loss of T-helper 1 populations in spleen of mice during progressive tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo administration of purified human interleukin-2 to patients with cancer: development of interleukin-2 receptor positive cells and circulating soluble interleukin-2 receptors following interleukin-2 administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2 and interleukin-4 display potent antitumour activity on rat medullary thyroid carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic Value of Intratumoral Interferon Gamma Messenger RNA Expression in Invasive Cervical Carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Locoregional response and increased natural killer activity after intratumoral injection of HLA-B7/beta2-microglobulin gene in patients with cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer immunotherapy by direct in vivo transfer of immunomodulatory genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autologous, hapten-modified vaccine as a treatment for human cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local administration of cells containing an inserted IL-2 gene and producing IL-2 inhibits growth of human tumours in nu/nu mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo production of interleukin-5, granulocyte-macrophage colony-stimulating factor, macrophages colony-stimulating factor, and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11076653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1054/BJOC.2000.1492

1 reference

Europe PubMed Central

15 August 2017

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0 references

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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