(Q36624938)

15 August 2017

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title

Development of CRF1 receptor antagonists as antidepressants and anxiolytics: progress to date (English)

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15 August 2017

Glenn R Valdez

1

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15 August 2017

1 January 2006

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15 August 2017

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15 August 2017

20

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15 August 2017

887-896

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15 August 2017

11

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https://scigraph.springernature.com/pub.10.2165/00023210-200620110-00002

15 August 2017

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cites work

Lateral and medial septal lesions reduce anxiety in the plus-maze and probe-burying tests

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00023210-200620110-00002

Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450.

21 January 2018

1 reference

12 December 2020

The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat.

1 reference

12 December 2020

The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats

1 reference

12 December 2020

Involvement of corticotropin-releasing factor subtype 1 receptor in the acquisition phase of learned helplessness in rats.

1 reference

12 December 2020

Anxiogenic-like effect of corticotropin-releasing factor receptor 2 antisense oligonucleotides infused into rat brain.

1 reference

12 December 2020

Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development

1 reference

12 December 2020

Corticotropin releasing factor produces behavioural activation in rats.

1 reference

12 December 2020

Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist

1 reference

12 December 2020

Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects

1 reference

12 December 2020

Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression

1 reference

12 December 2020

Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression.

1 reference

12 December 2020

Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain.

1 reference

12 December 2020

Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors

1 reference

12 December 2020

A role for corticotropin releasing factor and urocortin in behavioral responses to stressors.

1 reference

12 December 2020

Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart

1 reference

12 December 2020

Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior.

1 reference

12 December 2020

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

1 reference

12 December 2020

Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone.

1 reference

12 December 2020

The Flinders Sensitive Line rat: a selectively bred putative animal model of depression

1 reference

12 December 2020

Effects of Alpha-Flupenthixol and Naloxone on CRF-Induced Locomotor Activation

1 reference

12 December 2020

In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation

1 reference

12 December 2020

Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression.

1 reference

12 December 2020

Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice

1 reference

12 December 2020

Corticotropin-releasing hormone receptor (type I) antisense targeting reduces anxiety.

1 reference

12 December 2020

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine hydrochloride (SSR125543A), a potent and selective corticotrophin-releasing factor(1) receptor antagonist. II.

1 reference

12 December 2020

The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) Surveys.

1 reference

12 December 2020

Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression.

1 reference

12 December 2020

Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats

1 reference

12 December 2020

Chronic effects of a nonpeptide corticotropin-releasing hormone type I receptor antagonist on pituitary-adrenal function, body weight, and metabolic regulation.

1 reference

12 December 2020

Economic costs of anxiety disorders.

1 reference

12 December 2020

Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice.

1 reference

12 December 2020

Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin

1 reference

12 December 2020

Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims

1 reference

12 December 2020

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

1 reference

12 December 2020

Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2

1 reference

12 December 2020

A CRH1 antagonist into the amygdala of mice prevents defeat-induced defensive behavior

1 reference

12 December 2020

Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat.

1 reference

12 December 2020

Characterization of a novel and potent corticotropin-releasing factor antagonist in rats.

1 reference

12 December 2020

Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice

1 reference

12 December 2020

Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders

1 reference

12 December 2020

The corticotropin-releasing hormone test in patients with posttraumatic stress disorder

1 reference

12 December 2020

Differential monoaminergic, neuroendocrine and behavioural responses after central administration of corticotropin-releasing factor receptor type 1 and type 2 agonists.

1 reference

12 December 2020

The role of the lateral septum in anxiolysis.

1 reference

12 December 2020

The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress1

1 reference

12 December 2020

Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression

1 reference

12 December 2020

CRF antagonist partially reverses CRF- and stress-induced effects on feeding.

1 reference

12 December 2020

Prevalence and treatment of mental disorders, 1990 to 2003

1 reference

12 December 2020

Urocortin III, a brain neuropeptide of the corticotropin-releasing hormone family: modulation by stress and attenuation of some anxiety-like behaviours

1 reference

12 December 2020

The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats.

1 reference

12 December 2020

The therapeutic potential of CRF1 antagonists for anxiety

1 reference

12 December 2020

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1 reference

12 December 2020

Depression: a new animal model sensitive to antidepressant treatments

1 reference

12 December 2020

Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2.

1 reference

12 December 2020

Behavioral effects of central administration of the novel CRF antagonist astressin in rats.

1 reference

12 December 2020

Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor.

1 reference

12 December 2020

Anti-stress action of a corticotropin-releasing factor antagonist on behavioral reactivity to stressors of varying type and intensity

1 reference

12 December 2020

Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior

1 reference

12 December 2020

Role of corticotropin-releasing factor (CRF) receptors in the anorexic syndrome induced by CRF

1 reference

12 December 2020

Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test

1 reference

12 December 2020

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.

1 reference

12 December 2020

Antidepressant-like effects of CP-154,526, a selective CRF1 receptor antagonist.

1 reference

12 December 2020

Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients

1 reference

12 December 2020

Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide

1 reference

12 December 2020

Corticotropin-releasing factor potentiates acoustic startle in rats: blockade by chlordiazepoxide.

1 reference

12 December 2020

Plasma corticotropin-releasing factor in depressed patients before and after the dexamethasone suppression test

1 reference

12 December 2020

Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice

1 reference

12 December 2020

CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.

1 reference

12 December 2020

Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?

1 reference

12 December 2020

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

1 reference

12 December 2020

Antagonism of CRF(2) receptors produces anxiolytic behavior in animal models of anxiety.

1 reference

12 December 2020

The pharmacology of DMP696 and DMP904, non-peptidergic CRF1 receptor antagonists.

1 reference

12 December 2020

Antalarmin, a putative CRH-RI antagonist, has transient reinforcing effects in rhesus monkeys

1 reference

12 December 2020

Appetite-suppressing effects of urocortin, a CRF-related neuropeptide.

1 reference

12 December 2020

Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress.

1 reference

12 December 2020

Chemical and Biological Characterization of Corticotropin Releasing Factor

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12 December 2020

Pharmacological evidence supporting a role for central corticotropin-releasing factor(2) receptors in behavioral, but not endocrine, response to environmental stress

1 reference

12 December 2020

Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by alpha-helical CRF (9-41).

1 reference

12 December 2020

Comorbid anxiety disorders in depressed elderly patients

1 reference

12 December 2020

Involvement of the hypothalamus-pituitary-adrenal axis in antidepressant activity of corticotropin-releasing factor subtype 1 receptor antagonists in the rat learned helplessness test.

1 reference

12 December 2020

CRF and urocortin decreased brain stimulation reward in the rat: reversal by a CRF receptor antagonist.

1 reference

12 December 2020

Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1.

1 reference

12 December 2020

Propranolol antagonizes the enhanced conditioned fear produced by corticotropin releasing factor

1 reference

12 December 2020

Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression

1 reference

12 December 2020

Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor

1 reference

12 December 2020

The corticotropin-releasing hormone stimulation test in patients with panic disorder.

1 reference

12 December 2020

Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 rec

1 reference

12 December 2020

In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation

1 reference

12 December 2020

The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress

1 reference

12 December 2020

10.2165/00023210-200620110-00002

Identifiers

DOI

1 reference

PubMed ID

17044726

Dimensions Publication ID

15 August 2017

0 references

1 reference

PubMed ID

17044726