(Q36646353)

English

Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function

scientific article published on 7 March 2008

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scholarly article

1 reference

Europe PubMed Central

15 August 2017

Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function (English)

1 reference

Europe PubMed Central

15 August 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Wei-Hua Shen

1

1 reference

Europe PubMed Central

15 August 2017

Zhuang Chen

2

1 reference

Europe PubMed Central

15 August 2017

Shu Shi

3

1 reference

Europe PubMed Central

15 August 2017

Hanying Chen

4

1 reference

Europe PubMed Central

15 August 2017

Wuqiang Zhu

5

1 reference

Europe PubMed Central

15 August 2017

Anne Penner

6

1 reference

Europe PubMed Central

15 August 2017

Guixue Bu

7

1 reference

Europe PubMed Central

15 August 2017

Wei Li

8

1 reference

Europe PubMed Central

15 August 2017

David W Boyle

9

1 reference

Europe PubMed Central

15 August 2017

Michael Rubart

10

1 reference

Europe PubMed Central

15 August 2017

Loren J Field

11

1 reference

Europe PubMed Central

15 August 2017

Robert Abraham

12

1 reference

Europe PubMed Central

15 August 2017

Edward A Liechty

13

1 reference

Europe PubMed Central

15 August 2017

Weinian Shou

14

1 reference

Europe PubMed Central

15 August 2017

language of work or name

0 references

publication date

7 March 2008

1 reference

Europe PubMed Central

15 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

15 August 2017

283

1 reference

Europe PubMed Central

15 August 2017

20

1 reference

Europe PubMed Central

15 August 2017

13842-13849

1 reference

Europe PubMed Central

15 August 2017

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Insulin and IGF-I stimulate the formation of the eukaryotic initiation factor 4F complex and protein synthesis in C2C12 myotubes independent of availability of external amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

BMP10 is essential for maintaining cardiac growth during murine cardiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Akt/protein kinase B promotes organ growth in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Mammalian TOR: a homeostatic ATP sensor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Regulation of translation initiation by FRAP/mTOR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

The TOR kinases link nutrient sensing to cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Ribosomal S6 kinase signaling and the control of translation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Isolation and characterization of the mouse cardiac myosin heavy chain genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

30 September 2017

Assessment of cardiomyocyte DNA synthesis during hypertrophy in adult mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

28 June 2018

Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

20 September 2018

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

20 September 2018

Rapamycin attenuates load-induced cardiac hypertrophy in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

20 September 2018

Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

20 September 2018

Akt signaling mediates postnatal heart growth in response to insulin and nutritional status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376248

20 September 2018

Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin inhibits alpha 1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survey of studies examining mammalian cardiomyocyte DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New method to evaluate myocyte remodeling from formalin-fixed biopsy and autopsy material

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M801510200

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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0 references

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