(Q36648773)

English

Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection

scientific article published on September 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Kari R Nations

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Roberta Bursi

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Peter Dogterom

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Larry Ereshefsky

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Lev Gertsik

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Tim Mant

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Jacques Schipper

7

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

publication date

1 September 2012

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

127-139

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

30 September 2017

Translational PK-PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

30 September 2017

The role of glutamate on the action of antidepressants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

30 September 2017

BL-1020, an oral antipsychotic agent that reduces dopamine activity and enhances GABAA activity, for the treatment of schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

30 September 2017

AMPA receptor potentiators: application for depression and Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

30 September 2017

Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

30 September 2017

A role for AMPA receptors in mood disorders

1 reference

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30 September 2017

Glutamate-based therapeutic approaches: ampakines

1 reference

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30 September 2017

Biowaivers for oral immediate-release products: implications of linear pharmacokinetics

1 reference

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30 September 2017

Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

30 September 2017

A bridging study of fananserin in schizophrenic patients.

1 reference

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30 September 2017

Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications

1 reference

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30 September 2017

Safety and tolerability of metrifonate in patients with Alzheimer's disease: results of a maximum tolerated dose study

1 reference

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30 September 2017

Clinical safety, tolerance, and plasma levels of the oral anticholinesterase 1,2,3,4-tetrahydro-9-aminoacridin-1-oL-maleate (HP 029) in Alzheimer's disease: preliminary findings

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

30 September 2017

An open-label tolerability study of BL-1020 antipsychotic: a novel gamma aminobutyric acid ester of perphenazine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

28 June 2018

Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

28 June 2018

Guidelines for conducting bridging studies in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

28 June 2018

Initial safety, tolerability pharmacodynamics, and pharmacokinetics of CI-1007 in patients with schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

28 June 2018

Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

28 June 2018

Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

28 June 2018

Increased levels of glutamate in brains from patients with mood disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

20 September 2018

Pharmacokinetics and pharmacodynamics of the novel daily rivastigmine transdermal patch compared with twice-daily capsules in Alzheimer's disease patients.

1 reference

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20 September 2018

Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

20 September 2018

Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

20 September 2018

Chronic AMPA receptor potentiator (LY451646) treatment increases cell proliferation in adult rat hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

20 September 2018

Pharmacokinetic-pharmacodynamic modeling of rivastigmine, a cholinesterase inhibitor, in patients with Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

20 September 2018

A multiple-dose safety trial of eptastigmine in Alzheimer's disease, with pharmacodynamic observations of red blood cell cholinesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585695

20 September 2018

The 16-Item quick inventory of depressive symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression

1 reference

https://api.crossref.org/works/10.2165%2F11634360-000000000-00000

21 January 2018

Correlation between plasma levels of glutamate, alanine and serine with severity of depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/22852579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigator perspective on MTD: practical application of an MTD definition--has it accelerated development?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22852579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scale for Suicide Ideation: psychometric properties of a self-report version

1 reference

https://pubmed.ncbi.nlm.nih.gov/22852579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defining the maximum tolerated dose: investigator, academic, industry and regulatory perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/22852579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/11634360-000000000-00000

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

ResearchGate publication ID

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