(Q36656419)

15 August 2017

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title

Pharmacogenetics of target genes across the warfarin pharmacological pathway (English)

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15 August 2017

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Suman Lal

1

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15 August 2017

Srinivasa Rao Jada

2

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15 August 2017

Xiaoqiang Xiang

3

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15 August 2017

Wan-Teck Lim

4

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15 August 2017

Edmund J D Lee

5

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15 August 2017

Balram Chowbay

6

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15 August 2017

publication date

1 January 2006

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Clinical Pharmacokinetics

15 August 2017

published in

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15 August 2017

volume

45

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15 August 2017

issue

12

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15 August 2017

page(s)

1189-1200

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A randomized trial comparing 5-mg and 10-mg warfarin loading doses.

15 August 2017

cites work

1 reference

12 December 2020

Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite

1 reference

12 December 2020

Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population.

1 reference

12 December 2020

Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members

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12 December 2020

Risk factors for bleeding in patients taking coumarins.

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12 December 2020

Genomic sequence and transcription start site for the human gamma-glutamyl carboxylase

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12 December 2020

Comparison of 10-mg and 5-mg warfarin initiation nomograms together with low-molecular-weight heparin for outpatient treatment of acute venous thromboembolism. A randomized, double-blind, controlled trial.

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12 December 2020

Interethnic variability of warfarin maintenance requirement is explained by VKORC1 genotype in an Asian population

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12 December 2020

A common genetic basis for idiosyncratic toxicity of warfarin and phenytoin.

1 reference

12 December 2020

Biochemistry and molecular biology of the human CYP2C subfamily

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12 December 2020

Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele

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12 December 2020

Gene:environment interaction in lipid metabolism and effect on coronary heart disease risk

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12 December 2020

Apolipoprotein E polymorphism and atherosclerosis

1 reference

12 December 2020

Apolipoprotein E (APOE) and warfarin dosing in an Italian population

1 reference

12 December 2020

Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process

1 reference

12 December 2020

Genetic polymorphisms and functional characterization of the 5'-flanking region of the human CYP2C9 gene: in vitro and in vivo studies

1 reference

12 December 2020

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

1 reference

12 December 2020

CYP2C9 haplotype structure in European American warfarin patients and association with clinical outcomes

1 reference

12 December 2020

Flexible induction dose regimen for warfarin and prediction of maintenance dose

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12 December 2020

The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade

1 reference

12 December 2020

Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin

1 reference

12 December 2020

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

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12 December 2020

The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism

1 reference

12 December 2020

Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations

1 reference

12 December 2020

Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype.

1 reference

12 December 2020

Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18

1 reference

12 December 2020

Genetic modulation of oral anticoagulation with warfarin

1 reference

12 December 2020

The effect of warfarin on mortality and reinfarction after myocardial infarction

1 reference

12 December 2020

Allelic and functional variability of cytochrome P4502C9.

1 reference

12 December 2020

Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study

1 reference

12 December 2020

Human apolipoprotein E. The complete amino acid sequence

1 reference

12 December 2020

Human hepatic cytochrome P450 2C9 catalyzes the rate-limiting pathway of torsemide metabolism

1 reference

12 December 2020

Upstream and coding region CYP2C9 polymorphisms: correlation with warfarin dose and metabolism

1 reference

12 December 2020

Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin

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12 December 2020

A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity.

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12 December 2020

Microsomal vitamin K-dependent carboxylase

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12 December 2020

Characterization of a unique human apolipoprotein E variant associated with type III hyperlipoproteinemia

1 reference

12 December 2020

A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin.

1 reference

12 December 2020

Warfarin dose related to apolipoprotein E (APOE) genotype

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12 December 2020

Association of Vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population

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12 December 2020

Genetic association between sensitivity to warfarin and expression of CYP2C9*3

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12 December 2020

Oral anticoagulant therapy in patients with coronary artery disease: a meta-analysis.

1 reference

12 December 2020

Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range

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12 December 2020

Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes

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12 December 2020

Apolipoprotein E genotyping in the Malay, Chinese and Indian ethnic groups in Malaysia-a study on the distribution of the different apoE alleles and genotypes

1 reference

12 December 2020

CYP2C9 genotypes and dose requirements during the induction phase of oral anticoagulant therapy

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12 December 2020

Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy.

1 reference

12 December 2020

The APOE gene and differences in life expectancy in Europe

1 reference

12 December 2020

Acenocoumarol stabilization is delayed in CYP2C93 carriers

1 reference

12 December 2020

APOE polymorphism and lipid profile in three ethnic groups in the Singapore population

1 reference

12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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12 December 2020

Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarin.

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12 December 2020

Studies on the optical enantiomorphs of warfarin in man

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12 December 2020

Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment.

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12 December 2020

Plasma transport of vitamin K in men using deuterium-labeled collard greens

1 reference

12 December 2020

Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin

1 reference

12 December 2020

Patients with an ApoE epsilon4 allele require lower doses of coumarin anticoagulants

1 reference

12 December 2020

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

1 reference

12 December 2020

CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

1 reference

12 December 2020

The inhibitory effect of calumenin on the vitamin K-dependent gamma-carboxylation system. Characterization of the system in normal and warfarin-resistant rats

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12 December 2020

Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C.

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12 December 2020

Warfarin resistance is associated with a protein component of the vitamin K 2,3-epoxide reductase enzyme complex in rat liver.

1 reference

12 December 2020

Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.

1 reference

12 December 2020

Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele?

1 reference

12 December 2020

Common genetic variants of microsomal epoxide hydrolase affect warfarin dose requirements beyond the effect of cytochrome P450 2C9.

1 reference

12 December 2020

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

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12 December 2020

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.

1 reference

12 December 2020

Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

1 reference

12 December 2020

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

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12 December 2020

High frequency of mutations related to impaired CYP2C9 metabolism in a Caucasian population

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12 December 2020

Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.

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12 December 2020

Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans

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12 December 2020

Interactions of warfarin with drugs and food

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12 December 2020

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

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12 December 2020

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

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12 December 2020

Differential lipoprotein transport pathways of K-vitamins in healthy subjects.

1 reference

12 December 2020

Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance.

1 reference

12 December 2020

The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase

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12 December 2020

Studies on the absorption and metabolism of phylloquinone (vitamin K1) in man.

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12 December 2020

Chromosomal localization of the gamma-glutamyl carboxylase gene at 2p12.

1 reference

12 December 2020

Role of cytochrome P-4502C9 in irbesartan oxidation by human liver microsomes

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man

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12 December 2020

Genetic analysis of CYP2C9 polymorphism in a Japanese population

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12 December 2020

Frequency of cytochrome P450 2C9 mutant alleles in a Korean population

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12 December 2020

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10

1 reference

12 December 2020

Plasma lipoproteins as carriers of phylloquinone (vitamin K1) in humans

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12 December 2020

Genetic analysis of the human cytochrome P450 CYP2C9 locus

1 reference

12 December 2020

Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and gamma-glutamyl carboxylase) gene variants with warfarin sensitivity

1 reference

12 December 2020

Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose

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12 December 2020

5'-Flanking region polymorphisms of CYP2C9 and their relationship to S-warfarin metabolism in white and Japanese patients

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12 December 2020

Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes

1 reference

12 December 2020

Common VKORC1 and GGCX polymorphisms associated with warfarin dose

1 reference

12 December 2020

Pharmacogenetics of warfarin elimination and its clinical implications

1 reference

12 December 2020

Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site

1 reference

12 December 2020

Identification of the gene for vitamin K epoxide reductase

1 reference

12 December 2020

Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9

1 reference

12 December 2020

10.2165/00003088-200645120-00004

Identifiers

DOI

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Dimensions Publication ID

15 August 2017

1049381540

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