(Q36662462)

15 August 2017

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title

Progress and obstacles in the development of an AIDS vaccine (English)

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15 August 2017

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1

Norman L Letvin

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15 August 2017

1 December 2006

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Nature Reviews Immunology

15 August 2017

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15 August 2017

6

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15 August 2017

930-939

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15 August 2017

12

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AIDS. Resource needs for HIV/AIDS.

15 August 2017

1 reference

Mechanisms of sexual transmission of HIV: does HIV infect intact epithelia?

21 January 2018

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HIV-1 sequence variation: drift, shift, and attenuation

21 January 2018

1 reference

Mouse models for HIV-1 infection

21 January 2018

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Simian Immunodeficiency Virus Infection of Chimpanzees

21 January 2018

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Transient High Levels of Viremia in Patients with Primary Human Immunodeficiency Virus Type 1 Infection

21 January 2018

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Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

21 January 2018

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Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus

21 January 2018

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Antibody neutralization and escape by HIV-1

21 January 2018

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CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication

21 January 2018

1 reference

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

21 January 2018

1 reference

Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection

21 January 2018

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Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes

21 January 2018

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Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.

21 January 2018

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Quantifying the uncertainty in forecasts of anthropogenic climate change

21 January 2018

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Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160.

21 January 2018

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Public health. AIDS vaccine trial produces disappointment and confusion

21 January 2018

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Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection.

21 January 2018

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Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial

21 January 2018

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Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies

21 January 2018

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Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

21 January 2018

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Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro

21 January 2018

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Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys.

21 January 2018

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Immunization with a modified vaccinia virus expressing simian immunodeficiency virus (SIV) Gag-Pol primes for an anamnestic Gag-specific cytotoxic T-lymphocyte response and is associated with reduction of viremia after SIV challenge

21 January 2018

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Simian immunodeficiency virus (SIV) gag DNA-vaccinated rhesus monkeys develop secondary cytotoxic T-lymphocyte responses and control viral replication after pathogenic SIV infection

21 January 2018

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Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.

21 January 2018

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Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination

21 January 2018

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Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infection

21 January 2018

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Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.

21 January 2018

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Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys

21 January 2018

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Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge

21 January 2018

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Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group

21 January 2018

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Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda

21 January 2018

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Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeys

21 January 2018

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Progress toward an HIV vaccine

21 January 2018

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Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. The National Institute of Allergy and Infectious Diseases AIDS Vaccine Ev

21 January 2018

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Immunization with recombinant canarypox vectors expressing membrane-anchored glycoprotein 120 followed by glycoprotein 160 boosting fails to generate antibodies that neutralize R5 primary isolates of human immunodeficiency virus type 1.

21 January 2018

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Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies

21 January 2018

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The antiviral activity of antibodies in vitro and in vivo.

21 January 2018

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HIV vaccine design and the neutralizing antibody problem

21 January 2018

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Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

21 January 2018

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Antibody vs. HIV in a clash of evolutionary titans

21 January 2018

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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

21 January 2018

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Structure of an unliganded simian immunodeficiency virus gp120 core

21 January 2018

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Human immunodeficiency virus infection among patients attending clinics for sexually transmitted diseases

21 January 2018

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The Association Between Genital Ulcer Disease and Acquisition of HIV Infection in Homosexual Men

21 January 2018

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A study of polio vaccination in infancy: excretion following challenge with live virus by children given killed or living poliovaccine

21 January 2018

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Elicitation of simian immunodeficiency virus-specific cytotoxic T lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination

21 January 2018

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Diversity considerations in HIV-1 vaccine selection

21 January 2018

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Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein

21 January 2018

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High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level.

21 January 2018

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Broad cross-clade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): importance of HLA anchor residue conservation

21 January 2018

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Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents

21 January 2018

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Expanded breadth of virus neutralization after immunization with a multiclade envelope HIV vaccine candidate

21 January 2018

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Multiclade human immunodeficiency virus type 1 envelope immunogens elicit broad cellular and humoral immunity in rhesus monkeys

21 January 2018

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Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope

21 January 2018

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Neutralizing antibodies and CD8+ T lymphocytes both contribute to immunity to adenovirus serotype 5 vaccine vectors

21 January 2018

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Immunogenicity of heterologous prime-boost regimens involving recombinant adenovirus serotype 11 (Ad11) and Ad35 vaccine vectors in the presence of anti-ad5 immunity

21 January 2018

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Chimpanzee-origin adenovirus vectors as vaccine carriers.

21 January 2018

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Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity

21 January 2018

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Immunogenicity of recombinant fiber-chimeric adenovirus serotype 35 vector-based vaccines in mice and rhesus monkeys

21 January 2018

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Generation of CD8+ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 Env.

21 January 2018

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Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L.

21 January 2018

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Beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization

21 January 2018

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Strategies for DNA vaccine delivery

21 January 2018

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Microparticles as vaccine adjuvants and delivery systems

21 January 2018

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Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

21 January 2018

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Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes

21 January 2018

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Evaluation of Monoclonal Antibodies to Human Immunodeficiency Virus Type 1 Primary Isolates by Neutralization Assays: Performance Criteria for Selecting Candidate Antibodies for Clinical Trials

21 January 2018

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Immunopathogenesis of HIV infection

21 January 2018

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Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

31 March 2020

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Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

31 March 2020

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Lessons from failure--preparing for future HIV-1 vaccine efficacy trials

31 March 2020

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High‐Dose Recombinant Canarypox Vaccine Expressing HIV‐1 Protein, in Seronegative Human Subjects

31 March 2020

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Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination

31 March 2020

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Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine

31 March 2020

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Non-viral vector as vaccine carrier

31 March 2020

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Potent immunogenicity of an HIV-1 gag-pol fusion DNA vaccine delivered by in vivo electroporation

31 March 2020

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Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines.

31 March 2020

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Seventeen-colour flow cytometry: unravelling the immune system

31 March 2020

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Dual tropism for macrophages and lymphocytes is a common feature of primary human immunodeficiency virus type 1 and 2 isolates.

31 March 2020

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7 January 2021

A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys.

1 reference

7 January 2021

Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys.

1 reference

7 January 2021

Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies.

1 reference

7 January 2021

Identifiers

DOI

10.1038/NRI1959

1 reference

15 August 2017

1 reference

PubMed ID

17124514