(Q36669875)

English

Highly specific inhibition of C1q globular-head binding to human IgG: a novel approach to control and regulate the classical complement pathway using an engineered single chain antibody variable fragment

scientific article published on 3 March 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Highly specific inhibition of C1q globular-head binding to human IgG: a novel approach to control and regulate the classical complement pathway using an engineered single chain antibody variable fragment (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Hee Young Hwang

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Marcus R Duvall

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Stephen Tomlinson

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Robert J Boackle

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

3 March 2008

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Molecular Immunology

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

45

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

2570-2580

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alpha1 chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Generation of inhibitory NFkappaB complexes and phosphorylated cAMP response element-binding protein correlates with the anti-inflammatory activity of complement protein C1q in human monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

OxLDL immune complexes activate complement and induce cytokine production by MonoMac 6 cells and human macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Complement-coated antibody-transfer (CCAT); serum IgA1 antibodies intercept and transport C4 and C3 fragments and preserve IgG1 deployment (PGD).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Novel collectin/C1q receptor mediates mast cell activation and innate immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Inhibition of C1q-beta-amyloid binding protects hippocampal cells against complement mediated toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Inflammation in neurodegenerative disease--a double-edged sword

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Complement component C1q modulates the phagocytosis of Abeta by microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Modular organization of proteins containing C1q-like globular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

The first subcomponent of complement, C1q, triggers the production of IL-8, IL-6, and monocyte chemoattractant peptide-1 by human umbilical vein endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Localization of the site on the complement component C1q required for the stimulation of neutrophil superoxide production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

The classical complement pathway: activation and regulation of the first complement component.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

A molecular mechanism for the activation of the first component of complement by immune complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Complement subcomponent C1q stimulates Ig production by human B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Protein folding in the cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Localization of the gene cluster encoding the A, B, and C chains of human C1q to 1p34.1-1p36.3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Subunit composition and structure of subcomponent C1q of the first component of human complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Activation of the Complement System by Antibody-Antigen Complexes: The Classical Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

An IgG primary sequence exposure theory for complement activation using synthetic peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

Active disassembly of the first complement component, C-1, by C-1 inactivator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

28 June 2018

C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

20 September 2018

The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

20 September 2018

Selective inhibition of the interaction of C1q with immunoglobulins and the classical pathway of complement activation by steroids and triterpenoids sulfates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

20 September 2018

Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

20 September 2018

Neuronal localization of C1q in preclinical Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

20 September 2018

High molecular weight non-immunoglobulin salivary agglutinins (NIA) bind C1Q globular heads and have the potential to activate the first complement component

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2393547

20 September 2018

Evidence for the binding of human serum amyloid P component to Clq and Fab gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18313756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/18313756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced Ig production by human peripheral lymphocytes induced by aggregated C1q

1 reference

https://pubmed.ncbi.nlm.nih.gov/18313756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The location of binding sites on C1q for DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/18313756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human serum amyloid P component oligomers bind and activate the classical complement pathway via residues 14-26 and 76-92 of the A chain collagen-like region of C1q

1 reference

https://pubmed.ncbi.nlm.nih.gov/18313756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18313756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18313756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A newly discovered function for C1 inhibitor, removal of the entire C1qr2s2 complex from immobilized human IgG subclasses

1 reference

https://pubmed.ncbi.nlm.nih.gov/18313756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C1 inhibitor removes the entire C1qr2s2 complex from anti-C1Q monoclonal antibodies with low binding affinities

1 reference

https://pubmed.ncbi.nlm.nih.gov/18313756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low C1-Inhibitor Levels Predict Early Restenosis After Eversion Carotid Endarterectomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18313756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural studies on human Clq: non-covalent and covalent subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/18313756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MOLIMM.2007.12.019

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

ResearchGate publication ID

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