(Q36673595)

15 August 2017

1 reference

title

Evaluation of which reactive metabolite, if any, is responsible for a specific idiosyncratic reaction (English)

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15 August 2017

Jack Uetrecht

1

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15 August 2017

language of work or name

English

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publication date

1 January 2006

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15 August 2017

published in

Drug Metabolism Reviews

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15 August 2017

volume

38

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15 August 2017

issue

4

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15 August 2017

page(s)

745-753

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A simple sequential incubation method for deconvoluting the complicated sequential metabolism of capravirine in humans

15 August 2017

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1 reference

https://api.crossref.org/works/10.1080%2F03602530600959615

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development

21 January 2018

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Electrospray ionization mass spectrometric analysis of intact cytochrome P450: identification of tienilic acid adducts to P450 2C9.

21 January 2018

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Can the pharmaceutical industry reduce attrition rates?

21 January 2018

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STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS.

21 January 2018

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Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600959615

Kinetics of tienilic acid bioactivation and functional generation of drug-protein adducts in intact rat hepatocytes

21 January 2018

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Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase

21 January 2018

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Tolerance, danger, and the extended family

21 January 2018

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Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States

21 January 2018

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Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600959615

Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism

21 January 2018

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The danger hypothesis applied to idiosyncratic drug reactions

21 January 2018

1 reference

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Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown Norway rat.

21 January 2018

1 reference

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Characterization of a potential animal model of an idiosyncratic drug reaction: nevirapine-induced skin rash in the rat.

21 January 2018

1 reference

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N-oxidation of drugs associated with idiosyncratic drug reactions

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600959615

Idiosyncratic liver injury: challenges and approaches.

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600959615

HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes.

21 January 2018

1 reference

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Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions

21 January 2018

1 reference

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Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity

21 January 2018

1 reference

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10.1080/03602530600959615

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference