(Q41172369)

27 September 2017

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title

Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism (English)

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27 September 2017

1

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27 September 2017

S Madden

2

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27 September 2017

B K Park

series ordinal

3

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27 September 2017

1 September 1996

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Clinical Pharmacokinetics

27 September 2017

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27 September 2017

31

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27 September 2017

215-230

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27 September 2017

3

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https://scigraph.springernature.com/pub.10.2165/00003088-199631030-00005

27 September 2017

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cites work

Diclofenac-associated hepatotoxicity: analysis of 180 cases reported to the Food and Drug Administration as adverse reactions

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12 December 2020

Metabolism of dapsone to a hydroxylamine by human neutrophils and mononuclear cells

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12 December 2020

Mechanism of hypersensitivity reactions: proposed involvement of reactive metabolites generated by activated leukocytes

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12 December 2020

A screening test for slow metabolisers of tolbutamide

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12 December 2020

Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population

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12 December 2020

Early stage autoinduction of carbamazepine metabolism in humans

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12 December 2020

Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP.

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12 December 2020

Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens

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12 December 2020

Clinical pharmacokinetics of dapsone

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12 December 2020

The immunologic and metabolic basis of drug hypersensitivities

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12 December 2020

Drug disposition and drug hypersensitivity

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12 December 2020

UDP-glucuronosyltransferases: a family of detoxifying enzymes

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12 December 2020

Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients

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12 December 2020

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12 December 2020

Metabolism of carbamazepine

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12 December 2020

The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients

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12 December 2020

Basic concepts in drug metabolism: Part I.

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12 December 2020

N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes

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12 December 2020

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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12 December 2020

Treatment of infections in the patient with acquired immunodeficiency syndrome

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12 December 2020

Pathogenesis of hypersensitivity reactions to drugs in patients with HIV infection: allergic or toxic?

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12 December 2020

Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency

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12 December 2020

Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo

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12 December 2020

Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6.

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12 December 2020

The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution

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12 December 2020

Glutathione transferase mu deficiency is not a marker for predisposition to sulphonamide toxicity

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12 December 2020

Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human

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12 December 2020

Biochemistry and molecular biology of the human CYP2C subfamily

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12 December 2020

Metabolism and bioactivation of clozapine by human liver in vitro

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12 December 2020

Drug-induced allergic hepatitis

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12 December 2020

Adverse reactions to co-trimoxazole in HIV infection

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12 December 2020

The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions

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12 December 2020

Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity

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12 December 2020

Idiosyncratic drug reactions: a mechanistic evaluation of risk factors

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12 December 2020

The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci

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12 December 2020

Carbamazepine-hypersensitivity: assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine.

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12 December 2020

The glutathione S-transferases: an update

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12 December 2020

Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.

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12 December 2020

The effect of acidosis on sympatho-adrenal stimulation. Particular reference to cardiopulmonary bypass

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12 December 2020

Formation of toxic metabolites from drugs and other xenobiotics by glutathione conjugation

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12 December 2020

Correlation of placental microsomal activities with protein detected by antibodies to rabbit cytochrome P-450 isozyme 6 in preparations from humans exposed to polychlorinated biphenyls, quaterphenyls, and dibenzofurans.

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12 December 2020

Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure

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12 December 2020

The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity

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12 December 2020

Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity

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12 December 2020

The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes

1 reference

12 December 2020

Flutamide and hepatitis

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12 December 2020

The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature

1 reference

12 December 2020

Protein-reactive metabolites of carbamazepine in mouse liver microsomes

1 reference

12 December 2020

Acute and chronic drug-induced hepatitis

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12 December 2020

Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes

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12 December 2020

Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.

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12 December 2020

Drugs 5 years later: carbamazepine

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12 December 2020

Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac

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12 December 2020

In vitro cytotoxicity as a marker of hypersensitivity to sulphamethoxazole in patients with HIV.

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12 December 2020

A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis

1 reference

12 December 2020

Cimetidine improves the therapeutic/toxic ratio of dapsone in patients on chronic dapsone therapy

1 reference

12 December 2020

The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.

1 reference

12 December 2020

Cytotoxic activity of T cells and non-T cells from diclofenac-immunized mice against cultured syngeneic hepatocytes exposed to diclofenac

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12 December 2020

Molecular genetics of the debrisoquin-sparteine polymorphism

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12 December 2020

Xenobiotic biotransformation/bioactivation in organogenesis-stage conceptual tissues: implications for embryotoxicity and teratogenesis

1 reference

12 December 2020

Prostaglandin H synthase and xenobiotic oxidation

1 reference

12 December 2020

An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro

1 reference

12 December 2020

Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis

1 reference

12 December 2020

Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization

1 reference

12 December 2020

CD8+ dermal T cells from a sulphamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes

1 reference

12 December 2020

Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies

1 reference

12 December 2020

An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes

1 reference

12 December 2020

Polymorphism at the P450IIE1 locus is not associated with alcoholic liver disease in Caucasian men

1 reference

12 December 2020

Systemic glutathione deficiency in symptom-free HIV-seropositive individuals

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12 December 2020

Neoantigens associated with halothane hepatitis

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12 December 2020

Renal Effects and Metabolism of Isoflurane in Man

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12 December 2020

Acetaminophen: enzymatic formation of a transient phenoxyl free radical

1 reference

12 December 2020

The effect of enzyme induction on the cytochrome P450-mediated bioactivation of carbamazepine by mouse liver microsomes

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12 December 2020

Renal toxicity of anaesthetics: with specific reference to the nephrotoxicity of methoxyflurane

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12 December 2020

Species variation in the bioactivation of tacrine by hepatic microsomes

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12 December 2020

Cytochromes P450: their active-site structure and mechanism of oxidation

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12 December 2020

Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?

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12 December 2020

Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation

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12 December 2020

A novel CYP1A1 gene polymorphism in African-Americans.

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12 December 2020

Ethanol-derived immunoreactive species formed by free radical mechanisms

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12 December 2020

Evidence for expression in human liver of halothane-induced neoantigens recognized by antibodies in sera from patients with halothane hepatitis

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12 December 2020

Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk

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12 December 2020

Increased levels of oxidized glutathione in CD4+ lymphocytes associated with disturbed intracellular redox balance in human immunodeficiency virus type 1 infection

1 reference

12 December 2020

Bioactivation and bioinactivation of drugs and drug metabolites: Relevance to adverse drug reactions

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12 December 2020

Prostaglandin endoperoxide synthetase-dependent cooxidation of acetaminophen to intermediates which covalently bind in vitro to rabbit renal medullary microsomes

1 reference

12 December 2020

N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity

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12 December 2020

Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions

1 reference

12 December 2020

The use of cimetidine as a selective inhibitor of dapsone N-hydroxylation in man.

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12 December 2020

Determination of human hepatic cytochrome P4501A2 activity in vitro use of tacrine as an isoenzyme-specific probe

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12 December 2020

Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites

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12 December 2020

The Role of Active Metabolites in Drug Toxicity

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12 December 2020

Mechanism of methemoglobin formation by diphenylsulfones. Effect of 4-amino-4'-hydroxyaminodiphenylsulfone and other p-substituted derivatives

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12 December 2020

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

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12 December 2020

Is enflurane hepatotoxic?

1 reference

12 December 2020

Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation

1 reference

12 December 2020

The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man

1 reference

12 December 2020

Immune responses to acetaldehyde-protein adducts: role in alcoholic liver disease

1 reference

12 December 2020

Effects of fluorine substitution on drug metabolism: pharmacological and toxicological implications

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12 December 2020

Measurement of in vivo microsomal epoxide hydrolase activity in white subjects

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12 December 2020

A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein

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12 December 2020

Possible role of free radical formation in clozapine (clozaril)-induced agranulocytosis

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12 December 2020

Metabolic polymorphisms

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12 December 2020

Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4

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12 December 2020

Human cytochromes P450: problems and prospects

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12 December 2020

Intra- and extra-cellular formation of metabolites from chemically reactive species

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12 December 2020

The molecular biology of cytochrome P450s.

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12 December 2020

The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence

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12 December 2020

Metabolic activation of carcinogens

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12 December 2020

Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure

1 reference

12 December 2020

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

1 reference

12 December 2020

Carbamazepine metabolism to a reactive intermediate by the myeloperoxidase system of activated neutrophils

1 reference

12 December 2020

Association between restriction fragment length polymorphism of the human cytochrome P450IIE1 gene and susceptibility to alcoholic liver cirrhosis

1 reference

12 December 2020

Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury

1 reference

12 December 2020

Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anesthesia in volunteers

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12 December 2020

Genetic polymorphisms of cytochrome P4502E1 related to the development of alcoholic liver disease

1 reference

12 December 2020

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

1 reference

12 December 2020

Drug hypersensitivity reactions and human immunodeficiency virus disease

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12 December 2020

Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors

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12 December 2020

Metabolism of carbamazepine and its epoxide metabolite in human and rat liver in vitro

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12 December 2020

The 1- and 2-electron oxidation of acetaminophen catalyzed by prostaglandin H synthase

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12 December 2020

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples

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12 December 2020

CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses

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12 December 2020

Role of dapsone hydroxylamine in dapsone-induced hemolytic anemia.

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12 December 2020

P450 genes: evolution, regulation, and relationship to human cancer and pharmacogenetics.

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12 December 2020

Immunohistological assessment of cutaneous drug hypersensitivity in patients with HIV infection

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12 December 2020

Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure

1 reference

12 December 2020

Metabolism of paracetamol to a glutathione conjugate catalyzed by prostaglandin synthetase

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12 December 2020

Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4

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12 December 2020

UDP-glucuronosyltransferases in the metabolic disposition of xenobiotics

1 reference

12 December 2020

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

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12 December 2020

Flutamide-induced liver failure

1 reference

12 December 2020

Mechanisms of halothane toxicity: novel insights

1 reference

12 December 2020

Clinical pharmacokinetics of tacrine.

1 reference

12 December 2020

Biochemical individuality and its implications for drug and carcinogen metabolism: recent insights from acetyltransferase and cytochrome P4501A2 phenotyping and genotyping in humans

1 reference

12 December 2020

Clinical enflurane metabolism by cytochrome P450 2E1.

1 reference

12 December 2020

Renal tubular site of action of fluoride in Fischer 344 rats

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12 December 2020

Genetic predisposition to alcoholic liver disease

1 reference

12 December 2020

Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians

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12 December 2020

Irreversible binding of zomepirac to plasma protein in vitro and in vivo

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12 December 2020

Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms

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12 December 2020

Molecular mechanisms of the hepatotoxicity caused by acetaminophen

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12 December 2020

Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene

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12 December 2020

The hepatic effects of sevoflurane

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12 December 2020

Autoantibodies against cytochromes P-450 in drug-induced autoimmune hepatitis

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12 December 2020

10.2165/00003088-199631030-00005

Identifiers

DOI

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Dimensions Publication ID

27 September 2017

1029837720

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Fatcat ID

release_y7736v4xbbc27aft247jd6ek7m

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Fatcat

https://api.fatcat.wiki/v0/release/y7736v4xbbc27aft247jd6ek7m

24 November 2022

mapped directly with Wikidata item

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