(Q36676608)

English

RNAi-mediated downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth.

scientific article published on November 2007

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17657740%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

retracted paper

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Retraction Watch

29 December 2023

https://doi.org/10.1002/ijc.33520

RNAi-mediated downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth (English)

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2 January 2020

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based on heuristic

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Christopher S Gondi

3

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2 January 2020

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Jasti S Rao

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2 January 2020

author name string

Sateesh Kunigal

1

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2 January 2020

Sajani S Lakka

2

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2 January 2020

Norman Estes

4

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2 January 2020

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1 November 2007

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2 January 2020

International Journal of Cancer

1 reference

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2 January 2020

121

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2 January 2020

2307-2316

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2 January 2020

10

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2 January 2020

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1 reference

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1 reference

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RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo

1 reference

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Specific interference of urokinase-type plasminogen activator receptor and matrix metalloproteinase-9 gene expression induced by double-stranded RNA results in decreased invasion, tumor growth, and angiogenesis in gliomas.

1 reference

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1 reference

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Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis.

1 reference

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Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion.

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CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase-type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells

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Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro

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30 September 2017

RNA interference: the new somatic cell genetics?

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30 September 2017

Matrix metalloproteinases: a tail of a frog that became a prince

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Plasmin/plasminogen system in colorectal cancer

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30 September 2017

Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells.

1 reference

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30 September 2017

Matrix metalloproteinases: they're not just for matrix anymore!

1 reference

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30 September 2017

The role of the plasminogen activation system in angiogenesis and metastasis

1 reference

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30 September 2017

Co-localization of CD44 and urokinase-type plasminogen activator on the surface of human melanoma cells.

1 reference

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30 September 2017

Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action

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30 September 2017

The plasminogen activator system: biology and regulation

1 reference

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30 September 2017

Matrix metalloproteinases in tumor invasion and metastasis

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30 September 2017

Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion

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Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes

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30 September 2017

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

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30 September 2017

A peptide derived from the non-receptor-binding region of urokinase plasminogen activator inhibits glioblastoma growth and angiogenesis in vivo in combination with cisplatin

1 reference

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30 September 2017

The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients

1 reference

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30 September 2017

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

1 reference

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30 September 2017

Role of urokinase receptor and caveolin in regulation of integrin signaling.

1 reference

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30 September 2017

In vivo angiogenic activity of urokinase: role of endogenous fibroblast growth factor-2.

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30 September 2017

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30 September 2017

Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype.

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Angiostatin generation by human pancreatic cancer

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30 September 2017

Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility

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Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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Metastatic potential correlates with enzymatic degradation of basement membrane collagen

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Plasminogen activators, tissue degradation, and cancer

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Basement membrane type IV collagen degradation: evidence for the involvement of a proteolytic cascade independent of metalloproteinases

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1 reference

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The urokinase-type plasminogen activator system in cancer metastasis: a review

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28 June 2018

Expression of multiple CD44 isoforms in the apical ectodermal ridge of the embryonic mouse limb.

1 reference

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28 June 2018

Matrix metalloproteinase 9 expression in primary human prostatic adenocarcinoma and benign prostatic hyperplasia

1 reference

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Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma

1 reference

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20 September 2018

Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production.

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1 reference

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Proteases as prognostic markers in cancer

1 reference

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based on heuristic

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MMP-9 secretion and MMP-2 activation distinguish invasive and metastatic sublines of a mouse mammary carcinoma system showing epithelial-mesenchymal transition traits

1 reference

https://pubmed.ncbi.nlm.nih.gov/17657740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/17657740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of matrix metalloproteinases - their role in tumor invasion and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17657740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/17657740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17657740

12 December 2020

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inferred from PubMed ID database lookup

Stromelysin-3 gene expression in human cancer: an overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/17657740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17657740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peptide derived from the nonreceptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo

1 reference

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inferred from PubMed ID database lookup

Expression and activity of MMPS and their regulators in ovarian cancer

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/IJC.22962

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17657740%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17657740%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

Europe PubMed Central

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2 January 2020

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