(Q36677504)

English

The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

scientific article published on 5 October 2011

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Kendra Garrison

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Tobias Hahn

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Wen-Cherng Lee

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Leona E Ling

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Andrew D Weinberg

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Emmanuel T Akporiaye

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

publication date

5 October 2011

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Cancer Immunology, Immunotherapy

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

61

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

511-521

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

https://scigraph.springernature.com/pub.10.1007/s00262-011-1119-y

0 references

Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Toll-like receptors, tissue injury, and tumourigenesis

1 reference

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30 September 2017

A systems level strategy for analyzing the cell death network: implication in exploring the apoptosis/autophagy connection.

1 reference

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30 September 2017

An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors

1 reference

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30 September 2017

The paradox of autophagy and its implication in cancer etiology and therapy

1 reference

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30 September 2017

Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers

1 reference

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30 September 2017

An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

OX40 costimulation turns off Foxp3+ Tregs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

1 reference

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30 September 2017

Trastuzumab: updates and future issues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

The costimulation-regulated duration of PKB activation controls T cell longevity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Trastuzumab-based combination therapy for breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Mechanism of action of trastuzumab and scientific update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Induction of anti-mammary cancer immunity by engaging the OX-40 receptor in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

New approaches to antibody therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

30 September 2017

Heterogeneity of tumor cells from a single mouse mammary tumor

1 reference

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30 September 2017

A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

28 June 2018

Elevated plasma levels of transforming growth factor (TGF)-beta1 and TGF-beta2 in patients with disseminated malignant melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

28 June 2018

Accurate identification of experimental pulmonary metastases

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28 June 2018

Life and death partners: apoptosis, autophagy and the cross-talk between them

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

5 September 2018

OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

5 September 2018

Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

5 September 2018

Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

5 September 2018

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

1 reference

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5 September 2018

Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

5 September 2018

Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth.

1 reference

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5 September 2018

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595193

5 September 2018

Engagement of the OX-40 receptor in vivo enhances antitumor immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indomethacin modulation of adriamycin-induced effects on multiple cytolytic effector functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breast

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated plasma transforming growth factor-beta 1 levels in breast cancer patients decrease after surgical removal of the tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated serum levels of transforming growth factor-beta1 in patients with colorectal carcinoma: its association with tumor progression and its significant decrease after curative surgical resection

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

OX40 (CD134) engagement drives differentiation of CD4+ T cells to effector cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterization of OX40 expressed on human CD8+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21971588

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00262-011-1119-Y

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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