(Q36681976)

15 August 2017

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title

Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates (English)

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15 August 2017

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Marc M Greenberg

1

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15 August 2017

14 November 2006

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Organic and Biomolecular Chemistry

15 August 2017

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15 August 2017

5

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15 August 2017

1

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15 August 2017

18-30

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Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin

15 August 2017

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Bleomycins: towards better therapeutics

21 January 2018

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Generation of a C-3'-thymidinyl radical in single-stranded oligonucleotides under anaerobic conditions

21 January 2018

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Independent Generation of 5-(2‘-Deoxycytidinyl)methyl Radical and the Formation of a Novel Cross-Link Lesion between 5-Methylcytosine and Guanine

21 January 2018

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Isolation of 2-deoxy-d-erythro-pentonic Acid from an Alkali-labile Site in γ-irradiated DNA

21 January 2018

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The release of 5-methylene-2-furanone from irradiated DNA catalyzed by cationic polyamines and divalent metal cations

21 January 2018

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2-Deoxyribonolactone lesions in X-ray-irradiated DNA: quantitative determination by catalytic 5-methylene-2-furanone release

21 January 2018

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The reactivity of the 2-deoxyribonolactone lesion in single-stranded DNA and its implication in reaction mechanisms of DNA damage and repair

21 January 2018

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Half-life and DNA strand scission products of 2-deoxyribonolactone oxidative DNA damage lesions

21 January 2018

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3-nitro-3-deaza-2'-deoxyadenosine as a versatile photocleavable 2'-deoxyadenosine mimic.

21 January 2018

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A minor groove binding copper-phenanthroline conjugate produces direct strand breaks via beta-elimination of 2-deoxyribonolactone

21 January 2018

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Mechanistic studies on DNA damage by minor groove binding copper-phenanthroline conjugates

21 January 2018

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Chemistry and biology of DNA repair

21 January 2018

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Envisioning the molecular choreography of DNA base excision repair

21 January 2018

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Instability and decay of the primary structure of DNA

21 January 2018

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Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

21 January 2018

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The 2-deoxyribonolactone lesion produced in DNA by neocarzinostatin and other damaging agents forms cross-links with the base-excision repair enzyme endonuclease III.

21 January 2018

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Cross-linking of 2-deoxyribonolactone and its beta-elimination product by base excision repair enzymes

21 January 2018

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DNA-protein cross-link formation mediated by oxanine. A novel genotoxic mechanism of nitric oxide-induced DNA damage

21 January 2018

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Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA.

21 January 2018

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Repair of oxidized abasic sites by exonuclease III, endonuclease IV, and endonuclease III.

21 January 2018

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Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone

21 January 2018

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Endonuclease-resistant apyrimidinic sites formed by neocarzinostatin at cytosine residues in DNA: evidence for a possible role in mutagenesis

21 January 2018

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Long-patch base excision DNA repair of 2-deoxyribonolactone prevents the formation of DNA-protein cross-links with DNA polymerase beta

21 January 2018

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Free radical-induced damage to DNA: mechanisms and measurement

21 January 2018

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C5'- and C3'-sugar radicals produced via photo-excitation of one-electron oxidized adenine in 2'-deoxyadenosine and its derivatives

21 January 2018

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Yields of radiation-induced main chain scission of poly U in aqueous solution: strand break formation via base radicals

21 January 2018

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Tandem Lesions Are the Major Products Resulting from a Pyrimidine Nucleobase Radical

21 January 2018

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Independent generation and study of 5,6-Dihydro-2'-deoxyuridin-6-yl, a member of the major family of reactive intermediates formed in DNA from the effects of gamma-radiolysis

21 January 2018

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Evidence for glycosidic bond rotation in a nucleobase peroxyl radical and its effect on tandem lesion formation

21 January 2018

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Independent generation of the 5-hydroxy-5,6-dihydrothymidin-6-yl radical and its reactivity in dinucleoside monophosphates.

21 January 2018

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Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA.

21 January 2018

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Response of base excision repair enzymes to complex DNA lesions

21 January 2018

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Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response

21 January 2018

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The reactivity of the 5-hydroxy-5,6-dihydrothymidin-6-yl radical in oligodeoxyribonucleotides.

21 January 2018

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Identification and quantification of a guanine-thymine intrastrand cross-link lesion induced by Cu(II)/H2O2/ascorbate

21 January 2018

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Synthesis and UV photolysis of oligodeoxynucleotides that contain 5-(phenylthiomethyl)-2'-deoxyuridine: a specific photolabile precursor of 5-(2'-deoxyuridilyl)methyl radical

21 January 2018

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5-(phenylthiomethyl)-2'-deoxyuridine as an efficient photoreactive precursor to generate single and multiple lesions within DNA fragments

21 January 2018

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Generation of 5-(2'-deoxycytidyl)methyl radical and the formation of intrastrand cross-link lesions in oligodeoxyribonucleotides

21 January 2018

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Independent generation and reactivity of 2-deoxy-5-methyleneuridin-5-yl, a significant reactive intermediate produced from thymidine as a result of oxidative stress

21 January 2018

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Oxygen independent DNA interstrand cross-link formation by a nucleotide radical

21 January 2018

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Efficient DNA interstrand cross-link formation from a nucleotide radical

21 January 2018

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The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity

21 January 2018

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Formation and repair of interstrand cross-links in DNA

21 January 2018

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Sequence preferences of DNA interstrand crosslinking agents: quantitation of interstrand crosslink locations in DNA duplex fragments containing multiple crosslinkable sites

21 January 2018

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Exploiting tumour hypoxia in cancer treatment

21 January 2018

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Radiosensitization by bromodeoxyuridine and hyperthermia: analysis of linear and quadratic parameters of radiation survival curves of two human tumor cell lines.

21 January 2018

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Radiosensitization by a modified nucleotide that produces DNA interstrand cross-links under hypoxic conditions

21 January 2018

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DNA interstrand cross-link formation initiated by reaction between singlet oxygen and a modified nucleotide

21 January 2018

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Formation of 13C-, 15N-, and 18O-Labeled Guanidinohydantoin from Guanosine Oxidation with Singlet Oxygen. Implications for Structure and Mechanism

21 January 2018

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Singlet oxygen induces oxidation of cellular DNA.

21 January 2018

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Photodynamic therapy for cancer

21 January 2018

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Rates and equilibria in the interconversion of allylic sulfoxides and sulfenates

21 January 2018

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Site-Specific Generation of Deoxyribonolactone Lesions in DNA Oligonucleotides

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B612729K

1 reference

15 August 2017

1 reference

PubMed ID

17164902