(Q41735615)

8 October 2017

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title

The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity (English)

1 reference

8 October 2017

Tomasz M

1

1 reference

PubMed ID

9535170

8 October 2017

Palom Y

series ordinal

2

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8 October 2017

1 October 1997

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Pharmacology & Therapeutics

8 October 2017

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8 October 2017

76

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8 October 2017

73-87

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8 October 2017

1-3

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Structural, conformational, and theoretical binding studies of antitumor antibiotic porfiromycin (N-methylmitomycin C), a covalent binder of DNA, by X-ray, NMR, and molecular mechanics

8 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Effect of site-specifically located mitomycin C-DNA monoadducts on in vitro DNA synthesis by DNA polymerases.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

DNA methylation and the frequency of CpG in animal DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Isolation and structure of an intrastrand cross-link adduct of mitomycin C and DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Duplex oligodeoxyribonucleotides cross-linked by mitomycin C at a single site: synthesis, properties, and cross-link reversibility.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Recognition between mitomycin C and specific DNA sequences for cross-link formation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Relationships between functionality and genetic toxicology of selected DNA-damaging agents

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Preferential effects of the chemotherapeutic DNA crosslinking agent mitomycin C on inducible gene expression in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

DNA crosslinking, sister-chromatid exchange and specific-locus mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Re-evaluation of the molecular pharmacology of mitomycin C.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Free-radical mechanisms involved in the formation of sequence-dependent bistranded DNA lesions by the antitumor antibiotics bleomycin, neocarzinostatin, and calicheamicin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Cross-link repair in human cells and its possible defect in Fanconi's anemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Circumvention of glutathione-mediated mitomycin C resistance by a novel mitomycin C analogue, KW-2149.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Selective recognition of the m5CpG dinucleotide sequence in DNA by mitomycin C for alkylation and cross-linking

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Altered physiochemical properties of the deoxyribonucleic acid-mitomycin C complex. Evidence for the conformational change in deoxyribonucleic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Modification of DNA by mitomycin C in cancer patients detected by 32P-postlabeling analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

The hypoxic tumor cell: a target for selective cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Cytotoxicity and DNA crosslinks produced by mitomycin analogs in aerobic and hypoxic EMT6 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Synthesis and antitumor activity of a novel water soluble mitomycin analog; 7-N-[2-[[2-(gamma-L-glutamylamino)ethyl]dithio]ethyl]mitomycin C.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Recognition of specific DNA sequences by mitomycin C for alkylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Use of restriction enzymes to detect potential gene sequences in mammalian DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

A new antitumor antibiotic, FR-900482: V. Interstrand DNA-DNA cross-links in L1210 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Repair analysis of mitomycin C-induced DNA crosslinking in ribosomal RNA genes in lymphoblastoid cells from Fanconi's anemia patients

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Reductive alkylation of DNA by mitomycin A, a mitomycin with high redox potential

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Cytosine methylation enhances mitomycin C cross-linking

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Bioactivation as a model for drug design bioreductive alkylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

NMR and computational characterization of mitomycin cross-linked to adjacent deoxyguanosines in the minor groove of the d(T-A-C-G-T-A).d(T-A-C-G-T-A) duplex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Deoxyribonucleic Acid Damage by Monofunctional Mitomycins and Its Repair in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Porfiromycin disposition in oxygen-modulated P388 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Autocatalytic quinone methide formation from mitomycin c.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Noncovalent binding of a mitomycin C metabolite, 2,7-diaminomitosene, to duplex DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Sequence-selective alkylation and cross-linking induced by mitomycin C upon activation by DT-diaphorase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

32P-analysis of DNA adducts in somatic and reproductive tissues of rats treated with the anticancer antibiotic, mitomycin C

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Active mammalian replication origins are associated with a high-density cluster of mCpG dinucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Conformations of complexes between mitomycins and decanucleotides. 3. Sequence specificity, binding at C-10, and mitomycin analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Bending of DNA by the mitomycin C-induced, GpG intrastrand cross-link

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Solution structure of the monoalkylated mitomycin C-DNA complex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Generation of free radicals from neocarzinostatin mediated by NADPH/cytochrome P-450 reductase via activation of enediyne chromophore

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Bioreductive activation of mitomycin C by DT-diaphorase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

The case for mitomycin in non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Binding of 2,7-diaminomitosene to DNA: model for the precovalent recognition of DNA by activated mitomycin C

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

DNA sequence specificity of mitomycin cross-linking

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Mitomycin C: small, fast and deadly (but very selective)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

The mode of interaction of mitomycin C with deoxyribonucleic acid and other polynucleotides in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

Synthesis and structural characterization of the N2G-mitomycin C-N2G interstrand cross-link in a model synthetic 23 base pair oligonucleotide DNA duplex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

FR900482, a close cousin of mitomycin C that exploits mitosene-based DNA cross-linking

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900088-0

7 January 2021

10.1016/S0163-7258(97)00088-0

Identifiers

DOI

1 reference

8 October 2017

1 reference

PubMed ID

9535170