(Q36704645)

15 August 2017

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title

The role of STATs in lung carcinogenesis: an emerging target for novel therapeutics (English)

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15 August 2017

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Michalis V Karamouzis

series ordinal

1

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15 August 2017

Panagiotis A Konstantinopoulos

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2

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15 August 2017

Athanasios G Papavassiliou

series ordinal

3

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15 August 2017

publication date

10 January 2007

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Journal of Molecular Medicine

15 August 2017

published in

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15 August 2017

volume

85

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15 August 2017

issue

5

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15 August 2017

page(s)

427-436

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https://scigraph.springernature.com/pub.10.1007/s00109-006-0152-3

15 August 2017

exact match

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cites work

Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-006-0152-3

Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-006-0152-3

Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-006-0152-3

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice

21 January 2018

1 reference

12 December 2020

PIASxalpha differentially regulates the amplitudes of transcriptional responses following activation of the ERK and p38 MAPK pathways

1 reference

12 December 2020

PIAS proteins and transcriptional regulation--more than just SUMO E3 ligases?

1 reference

12 December 2020

Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility

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12 December 2020

Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas

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12 December 2020

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

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12 December 2020

In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.

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12 December 2020

Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor

1 reference

12 December 2020

STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.

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12 December 2020

The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells

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12 December 2020

Negative regulation of cytokine signaling

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12 December 2020

SUMO-1 conjugation selectively modulates STAT1-mediated gene responses

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12 December 2020

Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation

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12 December 2020

Nuclear receptors as negative modulators of STAT3 in multiple myeloma

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12 December 2020

Cyclin-dependent kinase pathways as targets for cancer treatment

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12 December 2020

Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck

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12 December 2020

Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling

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12 December 2020

Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinoma

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12 December 2020

Cell cycle alterations and lung cancer

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12 December 2020

Regulation of cytokine signaling pathways by PIAS proteins

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12 December 2020

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

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12 December 2020

Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer

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12 December 2020

Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes

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12 December 2020

Epidermal growth factor receptor targeting in cancer

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12 December 2020

The IGF-1 network in lung carcinoma therapeutics

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12 December 2020

Bifunctional recombinant proteins in cancer therapy: cell penetrating peptide aptamers as inhibitors of growth factor signaling

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12 December 2020

The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells

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12 December 2020

Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer

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12 December 2020

Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer

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12 December 2020

Phase I studies of imatinib mesylate combined with cisplatin and irinotecan in patients with small cell lung carcinoma

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12 December 2020

Signal transducers and activators of transcription: insights into the molecular basis of oral cancer.

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12 December 2020

Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy

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12 December 2020

Differentiation-dependent expression of signal transducers and activators of transcription (STATs) might modify responses to growth factors in the cancers of the head and neck

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12 December 2020

Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines

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12 December 2020

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

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12 December 2020

Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: current knowledge and future directions

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12 December 2020

The effect of epidermal growth factor receptor antisense morpholino oligomer on non-small cell lung cancer cell line

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12 December 2020

Are STATS arginine-methylated?

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12 December 2020

Inhibitors of cytokine signal transduction

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12 December 2020

Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.

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12 December 2020

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

12 December 2020

Stat1 and SUMO modification

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12 December 2020

SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling

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12 December 2020

Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion

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12 December 2020

The STATs of cancer--new molecular targets come of age

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12 December 2020

Oligonucleotides as anticancer agents: from the benchside to the clinic and beyond

1 reference

12 December 2020

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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12 December 2020

Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation

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12 December 2020

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

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12 December 2020

STAT3 as a therapeutic target in head and neck cancer

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12 December 2020

Coactivators in gene regulation by STAT5.

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12 December 2020

Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer

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12 December 2020

Increased myeloproliferation in glutathione S-transferase pi-deficient mice is associated with a deregulation of JNK and Janus kinase/STAT pathways

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12 December 2020

Clinical development of SRC tyrosine kinase inhibitors in lung cancer

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12 December 2020

A mutant signal transducer and activator of transcription 5b, associated with growth hormone insensitivity and insulin-like growth factor-I deficiency, cannot function as a signal transducer or transcription factor

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12 December 2020

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

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12 December 2020

The role of Janus kinases in haemopoiesis and haematological malignancy

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12 December 2020

Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer.

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12 December 2020

Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells.

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12 December 2020

Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival

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12 December 2020

Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion.

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12 December 2020

Functional cross-modulation between SOCS proteins can stimulate cytokine signaling

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12 December 2020

Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma

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12 December 2020

Targeting multiple signal transduction pathways in lung cancer.

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12 December 2020

Overexpression of PIAS3 suppresses cell growth and restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivation

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12 December 2020

Comparative activity of Sant7 and anti-IL-6, IL-6R monoclonal antibodies in a murine model of B-cell lymphoma

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12 December 2020

The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells

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12 December 2020

Transcription factors and neoplasia: vistas in novel drug design.

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12 December 2020

Up-regulation of focal adhesion kinase in non-small cell lung cancer

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12 December 2020

10.1007/S00109-006-0152-3

Identifiers

DOI

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15 August 2017

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