(Q36705221)

English

Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration

scientific article published on November 1999

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

H Wang

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Q Cai

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

X Zeng

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

D Yu

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

S Agrawal

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

R Zhang

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

0 references

publication date

1 November 1999

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

number of pages

6

1 reference

based on heuristic

inferred from page(s)

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

96

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

24

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

13989-13994

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Antitumor activity and pharmacokinetics following oral administration of natural product DNA topoisomerase I inhibitors 10-hydroxycamptothecin and camptothecin in SCID mice bearing human breast cancer xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Regression of human colon cancer xenografts in SCID mice following oral administration of water-insoluble camptothecins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Transmodulation of epidermal growth factor receptor function by cyclic AMP-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Increased expression of the RIalpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Mixed backbone oligonucleotides: improvement in oligonucleotide-induced toxicity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

An overview of progress in antisense therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: in vitro and in vivo studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Activation of human B cells by phosphorothioate oligodeoxynucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Pharmacokinetic properties of several novel oligonucleotide analogs in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Regulation of multidrug resistance through the cAMP and EGF signalling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Inhibition of Plasmodium falciparum malaria using antisense oligodeoxynucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Protein kinase A (PK-A) regulatory subunit expression in colorectal cancer and related mucosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

The regulatory subunit of cAMP-dependent protein kinase as a target for chemotherapy of cancer and other cellular dysfunctional-related diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Transcriptional regulation of multidrug resistance in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

CpG motifs in bacterial DNA trigger direct B-cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Cyclic adenosine 3',5'-monophosphate binding proteins in human colorectal cancer and mucosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Antisense oligonucleotides: towards clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

30 September 2017

Advances in understanding the pharmacological properties of antisense oligonucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

28 June 2018

Antisense-protein kinase A: a single-gene-based therapeutic approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

28 June 2018

In vivo metabolic profile of a phosphorothioate oligodeoxyribonucleotide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

28 June 2018

Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

28 June 2018

Pharmacokinetics of an anti—human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV-infected subjects*

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

28 June 2018

Transfection of a mutant regulatory subunit gene of cAMP-dependent protein kinase causes increased drug sensitivity and decreased expression of P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

28 June 2018

Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Antisense c-myc and immunostimulatory oligonucleotide inhibition of tumorigenesis in a murine B-cell lymphoma transplant model

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Changes in messenger RNA expression of protein kinase A regulatory subunit ialpha in breast cancer patients treated with tamoxifen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

5 September 2018

A pharmacokinetic evaluation of 14C-labeled afovirsen sodium in patients with genital warts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

5 September 2018

An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24178

20 October 2018

Tumour cyclic AMP binding proteins: an independent prognostic factor for disease recurrence and survival in breast cancer

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Regulation of Lewis lung carcinoma invasion and metastasis by protein kinase A

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Growth-regulatory effect of gastrin on human colon cancer cell lines is determined by protein kinase a isoform content

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Novel function of the regulatory subunit of protein kinase A: regulation of cytochrome c oxidase activity and cytochrome c release

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Effects of RIalpha overexpression on cisplatin sensitivity in human ovarian carcinoma cells

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Antisense therapeutics

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Penetration of oligonucleotides into mouse organism through mucosa and skin

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

In vivo stability, disposition and metabolism of a "hybrid" oligonucleotide phosphorothioate in rats

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Large-scale synthesis, purification, and analysis of oligodeoxynucleotide phosphorothioates

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Vitravene--another piece in the mosaic

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.24.13989

21 January 2018

Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/10570186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel enzymatic and immunological responses to oligonucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/10570186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein kinase A increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10570186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic adenosine 3',5'-monophosphate-binding proteins in human ovarian cancer: correlations with clinicopathological features

1 reference

https://pubmed.ncbi.nlm.nih.gov/10570186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and tissue disposition of a chimeric oligodeoxynucleoside phosphorothioate in rats after intravenous administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/10570186

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.96.24.13989

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1999PNAS...9613989W

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

ResearchGate publication ID

0 references

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