(Q36711111)

English

Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells

scientific article published on 16 April 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1 reference

based on heuristic

inferred from title

author name string

Yashwanth Radhakrishnan

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Laura A Maile

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Yan Ling

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Lee M Graves

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

David R Clemmons

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

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publication date

16 April 2008

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Europe PubMed Central

PMC publication ID

15 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

15 August 2017

283

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

24

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

16320-16331

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2423238/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer

1 reference

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Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.

1 reference

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Phenotype-specific inhibition of the vascular smooth muscle cell cycle by high glucose treatment

1 reference

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Signalling through Class I PI3Ks in mammalian cells

1 reference

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Regulation of protein metabolism by insulin: value of different approaches and animal models

1 reference

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Association of Grb-2 and PI3K p85 with phosphotyrosile peptides derived from BTLA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423238

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GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway

1 reference

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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

1 reference

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Disruption of ShcA signaling halts cell proliferation--characterization of ShcC residues that influence signaling pathways using yeast

1 reference

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Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction

1 reference

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30 September 2017

Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423238

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Disruption of the Shc/Grb2 complex during abelson virus transformation affects proliferation, but not apoptosis

1 reference

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The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation

1 reference

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Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity

1 reference

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The phosphoinositide 3-kinase pathway

1 reference

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Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis.

1 reference

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Signaling via Shc family adapter proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423238

30 September 2017

Phosphoinositide 3-kinase signalling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423238

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Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo

1 reference

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30 September 2017

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

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30 September 2017

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

1 reference

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30 September 2017

The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines

1 reference

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30 September 2017

The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo

1 reference

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Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells

1 reference

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Requirement for Shc in TCR-mediated activation of a T cell hybridoma

1 reference

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30 September 2017

Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling

1 reference

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Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains

1 reference

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The IL-2 receptor promotes proliferation, bcl-2 and bcl-x induction, but not cell viability through the adapter molecule Shc.

1 reference

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30 September 2017

Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells

1 reference

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Insulin receptor substrate 1 antisense expression in an hepatoma cell line reduces cell proliferation and induces overexpression of the Src homology 2 domain and collagen protein (SHC).

1 reference

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A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3

1 reference

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Phosphatidylinositol 3' kinase: one of the effectors of Ras.

1 reference

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30 September 2017

Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor

1 reference

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Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites

1 reference

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

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Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.

1 reference

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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

1 reference

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Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins

1 reference

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30 September 2017

Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase

1 reference

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SH2 domains recognize specific phosphopeptide sequences

1 reference

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Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

1 reference

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Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for embrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth factor I receptor

1 reference

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High glucose and insulin in combination cause insulin receptor substrate-1 and -2 depletion and protein kinase B desensitisation in primary cultured rat adipocytes: possible implications for insulin resistance in type 2 diabetes.

1 reference

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Hyperglycemia alters the responsiveness of smooth muscle cells to insulin-like growth factor-I.

1 reference

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The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells.

1 reference

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Recruitment of the tyrosine phosphatase Src homology 2 domain tyrosine phosphatase-2 to the p85 subunit of phosphatidylinositol-3 (PI-3) kinase is required for insulin-like growth factor-I-dependent PI-3 kinase activation in smooth muscle cells

1 reference

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High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser1177 phosphorylation in human aortic endothelial cells.

1 reference

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1 reference

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1 reference

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1 reference

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IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyriboncleic acid synthesis by insulin-like growth factor-I

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombospondin and osteopontin bind to insulin-like growth factor (IGF)-binding protein-5 leading to an alteration in IGF-I-stimulated cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of an insulin-like growth factor-binding protein-4 protease that is secreted by smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18420583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M801687200

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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