(Q36722474)

15 August 2017

Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy (English)

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15 August 2017

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2

I F Tannock

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15 August 2017

J Luo

1

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PMCID

2033413

15 August 2017

language of work or name

English

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publication date

1 October 1994

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British Journal of Cancer

15 August 2017

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15 August 2017

70

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15 August 2017

617-624

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15 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/bjc.1994.360

15 August 2017

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cites work

Cytoplasmic pH and free Mg2+ in lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Metabolic regulation via intracellular pH

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

The relevance of tumour pH to the treatment of malignant disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

pH distributions in spontaneous and isotransplanted rat tumours

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Amiloride and its analogs as tools in the study of ion transport

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Effects of hydralazine on the blood flow in RIF-1 tumors and normal tissues of mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

The use of blood flow modifiers to improve the treatment response of solid tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Blood flow modification in the sccvii tumor: Effects of 5-Hydroxytryptamine, hydralazine, and propanolol

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Cell and environment interactions in tumor microregions: the multicell spheroid model

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Increased thermoresistance developed during growth of small multicellular spheroids.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Characterization of Na+-linked and Na+-independent Cl-/HCO3- exchange systems in Chinese hamster lung fibroblasts

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Inhibition of chemotactic factor-activated Na+/H+ exchange in human neutrophils by analogues of amiloride: structure-activity relationships in the amiloride series

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Reduction of intracellular pH as a possible mechanism for killing cells in acidic regions of solid tumors: effects of carbonylcyanide-3-chlorophenylhydrazone.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Relations between pH, oxygen partial pressure and growth in cultured cell spheroids.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Cisplatin and CCNU synergism in spheroid cell subpopulations

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033413

Pyrazine diuretics. II. N-amidino-3-amino-5-substituted 6-halopyrazinecarboxamides

5 September 2018

1 reference

12 December 2020

Increased radioresistance of cells in cultured multicell spheroids. I. Dependence on cellular interaction

1 reference

12 December 2020

Influences of growth conditions and cell-cell contact on responses of tumor cells to ultrasound

1 reference

12 December 2020

Flow cytometry studies of intracellular adriamycin in multicell spheroids in vitro

1 reference

12 December 2020

Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series

1 reference

12 December 2020

Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions

1 reference

12 December 2020

High-performance liquid chromatographic method for quantitating plasma levels of amiloride and its analogues

1 reference

12 December 2020

Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors

1 reference

12 December 2020

Chemosensitivity testing in V79 spheroids: drug delivery and cellular microenvironment

1 reference

12 December 2020

Flow cytometric measurement of cytoplasmic pH: A critical evaluation of available fluorochromes

1 reference

12 December 2020

Cytotoxicity of compounds that interfere with the regulation of intracellular pH: a potential new class of anticancer drugs

1 reference

12 December 2020

Role of chloride/bicarbonate antiport in the control of cytosolic pH. Cell-line differences in activity and regulation of antiport

1 reference

12 December 2020

Requirement of the Na+/H+ exchanger for tumor growth

1 reference

12 December 2020

Effects of hydralazine on in vivo tumor energy metabolism, hematopoietic radiation sensitivity, and cardiovascular parameters

1 reference

12 December 2020

High-performance liquid chromatographic determination of amiloride and its analogues in rat plasma

1 reference

12 December 2020

Drug induced perturbations in tumor blood flow: therapeutic potential and possible limitations

1 reference

12 December 2020

Effects of intercellular contact on repair of radiation damage

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJC.1994.360

1 reference

15 August 2017

1 reference

15 August 2017

1 reference

PMCID

2033413