(Q36725805)

15 August 2017

Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice (English)

1 reference

15 August 2017

Valeria De Nigris

5

0 references

Alba Gonzalez-Franquesa

object named as

Alba Gonzalez-Franquesa

7

0 references

Pablo M Garcia-Roves

object named as

Pablo M Garcia-Roves

8

0 references

Francesc Villarroya

object named as

Francesc Villarroya

14

0 references

author name string

Asma Ejaz

1

1 reference

15 August 2017

Laura Martinez-Guino

2

1 reference

15 August 2017

Allison B Goldfine

3

1 reference

15 August 2017

Francesc Ribas-Aulinas

4

1 reference

15 August 2017

Sílvia Ribó

6

1 reference

15 August 2017

Elizabeth Li

9

1 reference

15 August 2017

Jonathan M Dreyfuss

10

1 reference

15 August 2017

Walt Gall

11

1 reference

15 August 2017

Jason K Kim

12

1 reference

15 August 2017

Teodoro Bottiglieri

13

1 reference

15 August 2017

Robert E Gerszten

15

1 reference

15 August 2017

Mary-Elizabeth Patti

16

1 reference

15 August 2017

Carles Lerin

17

1 reference

15 August 2017

language of work or name

English

0 references

publication date

8 February 2016

1 reference

15 August 2017

11

1 reference

inferred from page(s)

published in

Diabetes

1 reference

15 August 2017

65

1 reference

15 August 2017

4

1 reference

15 August 2017

902-912

1 reference

describes a project that uses

15 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4806659/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.

30 September 2017

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Antiobesity Effect of a Small Molecule Repressor of RORγ.

30 September 2017

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Dimethylglycine Deficiency and the Development of Diabetes.

30 September 2017

1 reference

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S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages

30 September 2017

1 reference

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FGF21 is an endocrine signal of protein restriction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels

30 September 2017

1 reference

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Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.

30 September 2017

1 reference

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Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

30 September 2017

1 reference

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Interplay between FGF21 and insulin action in the liver regulates metabolism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

FGF21 promotes metabolic homeostasis via white adipose and leptin in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Metabolite profiling identifies pathways associated with metabolic risk in humans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Mouse betaine-homocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Metabolite profiles and the risk of developing diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Fibroblast growth factor 21: from pharmacology to physiology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Capacity of oxidative phosphorylation in human skeletal muscle: new perspectives of mitochondrial physiology.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Fibroblast growth factor 21 corrects obesity in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Methionine metabolism and liver disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Betaine in human nutrition

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Betaine alleviates hepatic lipid accumulation via enhancing hepatic lipid export and fatty acid oxidation in rats fed with a high-fat diet.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Beneficial antioxidant properties of betaine against oxidative stress mediated by levodopa/benserazide in the brain of rats.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Fibroblast growth factor 21 protects against cardiac hypertrophy in mice.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806659

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

5 September 2018

1 reference

12 December 2020

ACTIONS OF BETAINE, CARNITINE AND CHOLINE ON THE PATTERN OF HEPATIC LIPOSIS IN MICE FED A HIGH-FAT, LOW-PROTEIN DIET

1 reference

12 December 2020

Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women

1 reference

12 December 2020

Long-term fenofibrate therapy increases fibroblast growth factor 21 and retinol-binding protein 4 in subjects with type 2 diabetes

1 reference

12 December 2020

Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism

1 reference

12 December 2020

Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans

1 reference

12 December 2020

Alleviation of alcoholic liver injury by betaine involves an enhancement of antioxidant defense via regulation of sulfur amino acid metabolism

1 reference

12 December 2020

Dietary patterns, food groups, and nutrients as predictors of plasma choline and betaine in middle-aged and elderly men and women

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB15-1094

1 reference

15 August 2017

1 reference

15 August 2017

1 reference