(Q36733406)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

title

The TGR5 receptor mediates bile acid-induced itch and analgesia (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

3

1 reference

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27 February 2020

Martin Steinhoff

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

author name string

Farzad Alemi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Edwin Kwon

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

TinaMarie Lieu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Victoria Lyo

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Fiore Cattaruzza

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Ferda Cevikbas

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Romina Nassini

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Serena Materazzi

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Raquel Guerrero-Alba

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Eduardo Valdez-Morales

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Graeme S Cottrell

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Pierangelo Geppetti

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Stephen J Vanner

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Nigel W Bunnett

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Carlos U Corvera

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Kristina Schoonjans

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

language of work or name

English

0 references

publication date

25 March 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

27 February 2020

published in

1 reference

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27 February 2020

volume

123

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

page(s)

1513-1530

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

27 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3613908/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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1 reference

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TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

30 September 2017

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TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

30 September 2017

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Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids

30 September 2017

1 reference

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The itch of liver disease

30 September 2017

1 reference

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The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice

30 September 2017

1 reference

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Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord

30 September 2017

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TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch

30 September 2017

1 reference

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The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling

30 September 2017

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Neuroplasticity in vagal afferent neurons involved in cough

30 September 2017

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VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.

30 September 2017

1 reference

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30 September 2017

An itch to be scratched

1 reference

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The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

30 September 2017

1 reference

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Lysophosphatidic acid is a potential mediator of cholestatic pruritus

30 September 2017

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Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.

30 September 2017

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Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain?

30 September 2017

1 reference

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TGR5-mediated bile acid sensing controls glucose homeostasis

30 September 2017

1 reference

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Cellular basis of itch sensation

30 September 2017

1 reference

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TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

30 September 2017

1 reference

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Courvoisier's gallbladder: law or sign?

30 September 2017

1 reference

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Targeting bile-acid signalling for metabolic diseases

30 September 2017

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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

30 September 2017

1 reference

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Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.

30 September 2017

1 reference

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Review article: pruritus in cholestatic and other liver diseases

30 September 2017

1 reference

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A G protein-coupled receptor responsive to bile acids

30 September 2017

1 reference

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Identification of membrane-type receptor for bile acids (M-BAR)

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception.

30 September 2017

1 reference

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Specific C-receptors for itch in human skin.

30 September 2017

1 reference

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A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain

30 September 2017

1 reference

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Quantitative assessment of tactile allodynia in the rat paw

30 September 2017

1 reference

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Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum

30 September 2017

1 reference

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Plasma leucine enkephalin is increased in liver disease

30 September 2017

1 reference

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A controlled trial of naloxone infusions for the pruritus of chronic cholestasis

30 September 2017

1 reference

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Endogenous opioids accumulate in plasma in a rat model of acute cholestasis

30 September 2017

1 reference

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Itching for an explanation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Serum, cerebrospinal fluid, and brain levels of bile acids in patients with fulminant hepatic failure

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Detection of substance P in the central nervous system by a monoclonal antibody

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Effects of chemical modification of ursodeoxycholic acid on TGR5 activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Plasma bile acid levels and liver disease

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

[D-Phe12]bombesin analogues: a new class of bombesin receptor antagonists

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Co-localization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous, vascular and visceral sensory neurons of guinea pigs.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Central mu-opioid receptors are down-regulated in a rat model of cholestasis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Pruritic effect of bile salts.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

EASL Clinical Practice Guidelines: management of cholestatic liver diseases.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Mechanisms of protease-activated receptor 2-evoked hyperexcitability of nociceptive neurons innervating the mouse colon.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Peripheral antinociceptive effects of exogenous and immune cell-derived endomorphins in prolonged inflammatory pain.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Endogenous opioid-mediated antinociception in cholestatic mice is peripherally, not centrally, mediated

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Itch-scratch responses induced by lysophosphatidic acid in mice

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Presence of protein-bound unconjugated bile acids in the cytoplasmic fraction of rat brain

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Orthotopic liver transplant patients require less postoperative morphine than do patients undergoing hepatic resection

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Paraneoplastic and oncologic profiles of patients seropositive for type 1 antineuronal nuclear autoantibodies.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613908

Itching after intrathecal morphine. Incidence and treatment

4 December 2018

1 reference

12 December 2020

Acute Effects of Substance P and Calcitonin Gene-Related Peptide in Human Skin – A Microdialysis Study

1 reference

12 December 2020

Pruritus induced by crude bile and purified bile acids. Experimental production of pruritus in human skin

1 reference

12 December 2020

Immunohistochemical localization of leucine-enkephalin in the spinal cord of the cat: enkephalin-containing marginal neurons and pain modulation

1 reference

12 December 2020

Bile acid profiles of human serum and skin interstitial fluid and their relationship to pruritus studied by gas chromatography-mass spectrometry

1 reference

12 December 2020

Canine bombesin-like gastrin releasing peptides stimulate gastrin release and acid secretion in the dog

1 reference

12 December 2020

TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase

1 reference

12 December 2020

Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI64551

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23524965%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference