(Q37231731)

19 August 2017

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title

Targeting bile-acid signalling for metabolic diseases (English)

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19 August 2017

4

Johan Auwerx

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Kristina Schoonjans

series ordinal

5

object named as

Kristina Schoonjans

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Roberto Pellicciari

series ordinal

2

object named as

Roberto Pellicciari

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19 August 2017

3

Mark Pruzanski

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19 August 2017

Charles Thomas

1

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19 August 2017

1 August 2008

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Nature Reviews Drug Discovery

19 August 2017

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19 August 2017

7

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19 August 2017

678-693

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19 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrd2619

19 August 2017

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cites work

The enterohepatic nuclear receptors are major regulators of the enterohepatic circulation of bile salts

1 reference

Circadian distribution of bile acids in the enterohepatic circulatory system in rats

31 March 2020

1 reference

Within-day fluctuations in serum bile-acid concentrations among normal control subjects and patients with hepatic disease.

31 March 2020

1 reference

The enzymes, regulation, and genetics of bile acid synthesis

31 March 2020

1 reference

Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.

31 March 2020

1 reference

Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.

31 March 2020

1 reference

Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype

31 March 2020

1 reference

Cholestanol deposition in cerebrotendinous xanthomatosis. A possible mechanism.

31 March 2020

1 reference

The metabolism of cholestanol, cholesterol, and bile acids in cerebrotendinous xanthomatosis

31 March 2020

1 reference

The metabolism of chenodeoxycholic acid to beta-muricholic acid in rat liver

31 March 2020

1 reference

Identification of membrane-type receptor for bile acids (M-BAR)

31 March 2020

1 reference

A G protein-coupled receptor responsive to bile acids

31 March 2020

1 reference

Identification of a nuclear receptor for bile acids

31 March 2020

1 reference

Bile acids: natural ligands for an orphan nuclear receptor

31 March 2020

1 reference

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

31 March 2020

1 reference

Identification of a nuclear receptor that is activated by farnesol metabolites

31 March 2020

1 reference

Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol

31 March 2020

1 reference

Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters

31 March 2020

1 reference

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

31 March 2020

1 reference

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

31 March 2020

1 reference

Structural basis for bile acid binding and activation of the nuclear receptor FXR

31 March 2020

1 reference

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

31 March 2020

1 reference

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

31 March 2020

1 reference

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

31 March 2020

1 reference

Vitamin D receptor as an intestinal bile acid sensor

31 March 2020

1 reference

Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.

31 March 2020

1 reference

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

31 March 2020

1 reference

Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation

31 March 2020

1 reference

Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

31 March 2020

1 reference

Bile acid regulation of gene expression: roles of nuclear hormone receptors.

31 March 2020

1 reference

Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer

31 March 2020

1 reference

The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

31 March 2020

1 reference

FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine

31 March 2020

1 reference

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

31 March 2020

1 reference

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

31 March 2020

1 reference

Transcriptional corepression by SHP: molecular mechanisms and physiological consequences

31 March 2020

1 reference

In VivoImaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile Acid Signaling Tissue

31 March 2020

1 reference

International Union of Pharmacology. XLVI. G protein-coupled receptor list.

31 March 2020

1 reference

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

31 March 2020

1 reference

Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation

31 March 2020

1 reference

The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells

31 March 2020

1 reference

Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.

31 March 2020

1 reference

Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice.

31 March 2020

1 reference

Bile acid-induced TGR5-dependent c-Jun-N terminal kinase activation leads to enhanced caspase 8 activation in hepatocytes

31 March 2020

1 reference

Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells

31 March 2020

1 reference

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

31 March 2020

1 reference

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

31 March 2020

1 reference

The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity

31 March 2020

1 reference

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

31 March 2020

1 reference

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

31 March 2020

1 reference

The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by

31 March 2020

1 reference

Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression

31 March 2020

1 reference

Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

31 March 2020

1 reference

Identification of a hormonal basis for gallbladder filling.

31 March 2020

1 reference

Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho

31 March 2020

1 reference

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

31 March 2020

1 reference

Co-receptor requirements for fibroblast growth factor-19 signaling

31 March 2020

1 reference

Liver-specific activities of FGF19 require Klotho beta

31 March 2020

1 reference

Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha

31 March 2020

1 reference

Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: the National Cooperative Gallstone Study. A controlled trial of efficacy and safety

31 March 2020

1 reference

Different effects of chenodeoxycholic acid and ursodeoxycholic acid on serum lipoprotein concentrations in patients with radiolucent gallstones

31 March 2020

1 reference

Nuclear receptors and the control of metabolism

31 March 2020

1 reference

Changes in plasma triglyceride metabolism during withdrawal of bile

31 March 2020

1 reference

Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin.

31 March 2020

1 reference

Triglyceride-lowering effect of chenodeoxycholic acid in patients with endogenous hypertriglyceridaemia

31 March 2020

1 reference

Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids

31 March 2020

1 reference

The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner

31 March 2020

1 reference

Regulation of carbohydrate metabolism by the farnesoid X receptor

31 March 2020

1 reference

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

31 March 2020

1 reference

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

31 March 2020

1 reference

Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

31 March 2020

1 reference

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

31 March 2020

1 reference

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

31 March 2020

1 reference

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

31 March 2020

1 reference

Role of LXRs in control of lipogenesis

31 March 2020

1 reference

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

31 March 2020

1 reference

Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects

31 March 2020

1 reference

Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations

31 March 2020

1 reference

Genetic Variation in the Small Heterodimer Partner Gene and Young-Onset Type 2 Diabetes, Obesity, and Birth Weight in U.K. Subjects

31 March 2020

1 reference

Redundant pathways for negative feedback regulation of bile acid production

31 March 2020

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Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

31 March 2020

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Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

31 March 2020

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FXR signaling in metabolic disease

31 March 2020

1 reference

Measurement of mitochondrial calcium in single living cardiomyocytes by selective removal of cytosolic indo 1

31 March 2020

1 reference

Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea

31 March 2020

1 reference

Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity

31 March 2020

1 reference

The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes

31 March 2020

1 reference

Cholestyramine therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. A short-term, double-blind, crossover trial.

31 March 2020

1 reference

The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition.

31 March 2020

1 reference

Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle

31 March 2020

1 reference

Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

31 March 2020

1 reference

Farnesoid X receptor is essential for normal glucose homeostasis

31 March 2020

1 reference

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

31 March 2020

1 reference

Transient impairment of the adaptive response to fasting in FXR-deficient mice

31 March 2020

1 reference

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

31 March 2020

1 reference

Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes

31 March 2020

1 reference

Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes

31 March 2020

1 reference

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes

31 March 2020

1 reference

Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling

31 March 2020

1 reference

Improving metabolism by increasing energy expenditure

31 March 2020

1 reference

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

31 March 2020

1 reference

Targeting farnesoid X receptor for liver and metabolic disorders.

31 March 2020

1 reference

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

31 March 2020

1 reference

Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy

31 March 2020

1 reference

Identification of a chemical tool for the orphan nuclear receptor FXR.

31 March 2020

1 reference

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

31 March 2020

1 reference

Farnesoid X receptor: from structure to potential clinical applications

31 March 2020

1 reference

Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump

31 March 2020

1 reference

Identification of gene-selective modulators of the bile acid receptor FXR.

31 March 2020

1 reference

A natural product that lowers cholesterol as an antagonist ligand for FXR.

31 March 2020

1 reference

Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial

31 March 2020

1 reference

Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study

31 March 2020

1 reference

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

31 March 2020

1 reference

Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.

31 March 2020

1 reference

Effect of colestimide therapy for glycemic control in type 2 diabetes mellitus with hypercholesterolemia.

31 March 2020

1 reference

Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action

31 March 2020

1 reference

Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase

31 March 2020

1 reference

SC-435, an ileal apical sodium co-dependent bile acid transporter (ASBT) inhibitor lowers plasma cholesterol and reduces atherosclerosis in guinea pigs

31 March 2020

1 reference

An obesity-associated gut microbiome with increased capacity for energy harvest

31 March 2020

1 reference

A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model

31 March 2020

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Symbiotic gut microbes modulate human metabolic phenotypes

31 March 2020

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Modulation of longevity by environmental sensing.

31 March 2020

1 reference

The Physiology of Glucagon-like Peptide 1

31 March 2020

1 reference

Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration

31 March 2020

1 reference

Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.

31 March 2020

1 reference

A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

31 March 2020

1 reference

Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse

31 March 2020

1 reference

Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

31 March 2020

1 reference

A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

31 March 2020

1 reference

Formyl-peptide receptors revisited

31 March 2020

1 reference

Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors

31 March 2020

1 reference

Effect of cholestasis and bile acids on interferon-induced 2',5'-adenylate synthetase and NK cell activities.

31 March 2020

1 reference

Pharmacophore model for bile acids recognition by the FPR receptor

31 March 2020

1 reference

Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes

31 March 2020

1 reference

Bile acid-mediated induction of cyclooxygenase-2 and Mcl-1 in hepatic stellate cells

31 March 2020

1 reference

Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis

31 March 2020

1 reference

Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

31 March 2020

1 reference

Three hypotheses linking bile to carcinogenesis in the gastrointestinal tract: certain bile salts have properties that may be used to complement chemotherapy

31 March 2020

1 reference

Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo

31 March 2020

1 reference

Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

31 March 2020

1 reference

Molecular cloning and expression of rat liver bile acid CoA ligase

31 March 2020

1 reference

Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids

31 March 2020

1 reference

Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization

31 March 2020

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31 March 2020

Bile salt transporters

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Bile salt transporters: molecular characterization, function, and regulation

31 March 2020

1 reference

The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis

31 March 2020

1 reference

Nuclear bile acid receptor FXR as pharmacological target: are we there yet?

31 March 2020

1 reference

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

31 March 2020

1 reference

The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD2619

1 reference

PubMed ID

18670431

Dimensions Publication ID

19 August 2017

0 references

1 reference

PubMed ID

18670431