(Q36925551)

17 August 2017

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title

Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development (English)

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17 August 2017

Jürgen Wess

1

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17 August 2017

Richard M Eglen

series ordinal

2

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17 August 2017

Dinesh Gautam

series ordinal

3

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17 August 2017

publication date

1 September 2007

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Nature Reviews Drug Discovery

17 August 2017

published in

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17 August 2017

volume

6

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17 August 2017

issue

9

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17 August 2017

page(s)

721-733

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Molecular biology of muscarinic acetylcholine receptors

17 August 2017

cites work

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A multiplicity of muscarinic mechanisms: enough signaling pathways to take your breath away

31 March 2020

1 reference

Cellular signaling mechanisms for muscarinic acetylcholine receptors

31 March 2020

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Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus

31 March 2020

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Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder

31 March 2020

1 reference

Therapeutic opportunities for muscarinic receptors in the central nervous system

31 March 2020

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Therapeutic opportunities from muscarinic receptor research

31 March 2020

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Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications

31 March 2020

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Muscarinic receptor subtype pharmacology and physiology

31 March 2020

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Muscarinic receptors--characterization, coupling and function

31 March 2020

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Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice

31 March 2020

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Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice

31 March 2020

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Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice

31 March 2020

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Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype

31 March 2020

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Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean.

31 March 2020

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Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

31 March 2020

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Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice

31 March 2020

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Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice

31 March 2020

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Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents

31 March 2020

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Increased drinking in mutant mice with truncated M5 muscarinic receptor genes

31 March 2020

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Loss of anti-cataleptic effect of scopolamine in mice lacking muscarinic acetylcholine receptor subtype 4

31 March 2020

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Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus

31 March 2020

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Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling

31 March 2020

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M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice

31 March 2020

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Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice

31 March 2020

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Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice.

31 March 2020

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Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable.

31 March 2020

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A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

31 March 2020

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Functional analysis of muscarinic acetylcholine receptors using knockout mice

31 March 2020

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Scanning mutagenesis studies of the M1 muscarinic acetylcholine receptor

31 March 2020

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Allosterism at muscarinic receptors: ligands and mechanisms

31 March 2020

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Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity

31 March 2020

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Snake toxins with high selectivity for subtypes of muscarinic acetylcholine receptors.

31 March 2020

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Snake toxins that bind specifically to individual subtypes of muscarinic receptors

31 March 2020

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Discovery of an ectopic activation site on the M(1) muscarinic receptor

31 March 2020

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N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

31 March 2020

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The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine

31 March 2020

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On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

31 March 2020

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Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

31 March 2020

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The role of acetylcholine in learning and memory

31 March 2020

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Current pharmacotherapy for Alzheimer's disease

31 March 2020

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Cholinergic agonists and the treatment of Alzheimer's disease

31 March 2020

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M<sub>1</sub> Muscarinic Agonists Can Modulate Some of the Hallmarks in Alzheimer's Disease: Implications in Future Therapy

31 March 2020

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M1 receptors play a central role in modulating AD-like pathology in transgenic mice

31 March 2020

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Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells

31 March 2020

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Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain

31 March 2020

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The M1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons

31 March 2020

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M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices.

31 March 2020

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Molecular psychology: roles for the ERK MAP kinase cascade in memory

31 March 2020

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Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus.

31 March 2020

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Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex

31 March 2020

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Decreased input-specific plasticity of the auditory cortex in mice lacking M1 muscarinic acetylcholine receptors

31 March 2020

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Attention deficit/hyperactivity disorder: characteristics, interventions and models

31 March 2020

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Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

31 March 2020

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M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity.

31 March 2020

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Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice

31 March 2020

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Muscarinic receptors involved in hippocampal plasticity

31 March 2020

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Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice.

31 March 2020

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Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired.

31 March 2020

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Antisense oligodeoxynucleotides against the muscarinic m2, but not m4, receptor supports its role as autoreceptors in the rat hippocampus

31 March 2020

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SCH 57790, a selective muscarinic M(2) receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals

31 March 2020

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Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788.

31 March 2020

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Long-term effects of BIBN-99, a selective muscarinic M2 receptor antagonist, on improving spatial memory performance in aged cognitively impaired rats

31 March 2020

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Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.

31 March 2020

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The current status of the dopamine hypothesis of schizophrenia

31 March 2020

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Towards a muscarinic hypothesis of schizophrenia.

31 March 2020

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Muscarinic receptors as a target for drugs treating schizophrenia

31 March 2020

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Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia.

31 March 2020

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Elucidating the role of muscarinic receptors in psychosis

31 March 2020

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M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies

31 March 2020

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Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice.

31 March 2020

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Decreased amphetamine-induced locomotion and improved latent inhibition in mice mutant for the M5 muscarinic receptor gene found in the human 15q schizophrenia region.

31 March 2020

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Neurobiology of addiction

31 March 2020

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Neuroscience of addiction

31 March 2020

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M5 muscarinic receptors are required for prolonged accumbal dopamine release after electrical stimulation of the pons in mice

31 March 2020

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Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry.

31 March 2020

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Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia

31 March 2020

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Role for M5 muscarinic acetylcholine receptors in cocaine addiction.

31 March 2020

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Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice.

31 March 2020

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Functional activity of the M2 and M4 receptor subtypes in the spinal cord studied with muscarinic acetylcholine receptor knockout mice

31 March 2020

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Excitatory nicotinic and desensitizing muscarinic (M2) effects on C-nociceptors in isolated rat skin.

31 March 2020

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Muscarinic M2 receptors inhibit heat-induced CGRP release from isolated rat skin.

31 March 2020

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Muscarinic M2 receptors on peripheral nerve endings: a molecular target of antinociception.

31 March 2020

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Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors.

31 March 2020

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Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions

31 March 2020

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Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes

31 March 2020

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Differential expression of D1 and D2 dopamine and m4 muscarinic acetylcholine receptor proteins in identified striatonigral neurons

31 March 2020

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Muscarinic receptor subtypes in airways

31 March 2020

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Muscarinic acetylcholine receptors and airway diseases.

31 March 2020

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Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism

31 March 2020

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Therapeutic potential of thromboxane inhibitors in asthma

31 March 2020

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Muscarinic receptors in the bladder: from basic research to therapeutics

31 March 2020

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M(3)-receptor knockout mice: muscarinic receptor function in atria, stomach fundus, urinary bladder, and trachea

31 March 2020

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Muscarinic receptor knockout mice: role of muscarinic acetylcholine receptors M(2), M(3), and M(4) in carbamylcholine-induced gallbladder contractility

31 March 2020

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M(2) and M(3) muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice

31 March 2020

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Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice

31 March 2020

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Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studied with receptor knockout mice

31 March 2020

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Increased relaxant action of forskolin and isoproterenol against muscarinic agonist-induced contractions in smooth muscle from M2 receptor knockout mice

31 March 2020

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Drug effects on salivary glands: dry mouth

31 March 2020

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The management of Sjögren's syndrome

31 March 2020

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Understanding salivary fluid and protein secretion

31 March 2020

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Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and double-knockout mice

31 March 2020

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Use of muscarinic agonists in the treatment of Sjögren's syndrome

31 March 2020

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Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice.

31 March 2020

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Cholinergically stimulated gastric acid secretion is mediated by M(3) and M(5) but not M(1) muscarinic acetylcholine receptors in mice

31 March 2020

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Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function

31 March 2020

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The non-neuronal cholinergic system of human skin

31 March 2020

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Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes

31 March 2020

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Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization through M3 and M4 muscarinic receptors

31 March 2020

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Autonomic regulation of islet hormone secretion--implications for health and disease

31 March 2020

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Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice

31 March 2020

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Effects of muscarinic receptor type 3 knockout on mouse islet secretory responses

31 March 2020

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CHRM3 gene variation is associated with decreased acute insulin secretion and increased risk for early-onset type 2 diabetes in Pima Indians.

31 March 2020

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GPCR interacting proteins (GIP).

31 March 2020

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Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency

31 March 2020

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New insights into sympathetic regulation of glucose and fat metabolism

31 March 2020

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Up-regulated PAR-2-mediated salivary secretion in mice deficient in muscarinic acetylcholine receptor subtypes

31 March 2020

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Neural mechanisms in the control of blood glucose concentration

31 March 2020

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Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD2379

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release_crrkgkkdfzbtnnhpnmwyhgbig4

17 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/crrkgkkdfzbtnnhpnmwyhgbig4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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