(Q36564086)

14 August 2017

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title

Nuclear bile acid receptor FXR as pharmacological target: are we there yet? (English)

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14 August 2017

Salvatore Modica

1

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14 August 2017

Antonio Moschetta

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

8 August 2006

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14 August 2017

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14 August 2017

volume

580

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14 August 2017

issue

23

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14 August 2017

page(s)

5492-5499

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Orphan nuclear receptors--new ligands and new possibilities.

14 August 2017

cites work

1 reference

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Bile acids: natural ligands for an orphan nuclear receptor

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Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

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The continuing importance of bile acids in liver and intestinal disease

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21 January 2018

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The effects of cholestyramine on high density lipoprotein metabolism

21 January 2018

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Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

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Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

21 January 2018

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

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21 January 2018

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21 January 2018

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21 January 2018

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The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

21 January 2018

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New drug targets for type 2 diabetes and the metabolic syndrome

21 January 2018

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Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP

21 January 2018

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Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

21 January 2018

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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

21 January 2018

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Glucose regulates the expression of the farnesoid X receptor in liver

21 January 2018

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Farnesoid X receptor is essential for normal glucose homeostasis

21 January 2018

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Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

21 January 2018

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Transient impairment of the adaptive response to fasting in FXR-deficient mice

21 January 2018

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Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

21 January 2018

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The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

21 January 2018

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Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

21 January 2018

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Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis

21 January 2018

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Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice

21 January 2018

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Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

21 January 2018

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Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3

21 January 2018

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21 January 2018

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21 January 2018

1 reference

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FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

21 January 2018

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A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion

21 January 2018

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Lack of intestinal bile results in delayed liver regeneration of normal rat liver after hepatectomy accompanied by impaired cyclin E-associated kinase activity

21 January 2018

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Idiopathic bile acid catharsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

21 January 2018

1 reference

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The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

Identification of gene-selective modulators of the bile acid receptor FXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.07.082

10.1016/J.FEBSLET.2006.07.082

21 January 2018

Identifiers

DOI

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14 August 2017

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