(Q30453010)

English

Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes

scientific article published on May 1, 2003

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes (English)

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes (English)

1 reference

10.1128/MCB.23.9.3052-3066.2003

https://api.crossref.org/works/10.1128/MCB.23.9.3052-3066.2003

24 December 2023

apoptotic process

0 references

intracellular signaling peptides and proteins

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697808

24 December 2023

1 reference

10.1128/MCB.23.9.3052-3066.2003

https://api.crossref.org/works/10.1128/MCB.23.9.3052-3066.2003

24 December 2023

13

object named as

Paul Dent

1 reference

Europe PubMed Central

14 September 2017

PMC publication ID

Kristoffer Valerie

8

object named as

Kristoffer Valerie

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697808

24 December 2023

John F Engelhardt

10

object named as

John F. Engelhardt

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697808

24 December 2023

author name string

Liang Qiao

1

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Song Iy Han

2

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Youwen Fang

3

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Jong Sung Park

4

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Seema Gupta

5

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Donna Gilfor

6

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

George Amorino

7

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Linda Sealy

9

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Steven Grant

11

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Philip B. Hylemon

12

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697808

24 December 2023

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publication date

1 May 2003

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

full work available at URL

https://mcb.asm.org/content/mcb/23/9/3052.full.pdf

Portable Document Format

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697808

24 December 2023

https://europepmc.org/articles/PMC153195

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697808

24 December 2023

https://europepmc.org/articles/PMC153195?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697808

24 December 2023

https://doi.org/10.1128/mcb.23.9.3052-3066.2003

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697808

24 December 2023

https://journals.asm.org/doi/pdf/10.1128/MCB.23.9.3052-3066.2003

1 reference

10.1128/MCB.23.9.3052-3066.2003

https://api.crossref.org/works/10.1128/MCB.23.9.3052-3066.2003

24 December 2023

https://www.tandfonline.com/doi/pdf/10.1128/MCB.23.9.3052-3066.2003

1 reference

10.1128/MCB.23.9.3052-3066.2003

https://api.crossref.org/works/10.1128/MCB.23.9.3052-3066.2003

24 December 2023

Molecular and Cellular Biology

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

23

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

9

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

3052-3066

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Cyclin kinase inhibitor p21 potentiates bile acid-induced apoptosis in hepatocytes that is dependent on p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Alternative splicing variants of c-FLIP transduce the differential signal through the Raf or TRAF2 in TNF-induced cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Identification of a novel DNA regulatory element in the rabbit surfactant protein B (SP-B) promoter that is a target for ATF/CREB and AP-1 transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Growth hormone induces CCAAT/enhancer binding protein alpha (C/EBPalpha) in cultured rat hepatocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Chronic cholestatic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Mechanisms of liver cell injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Signal transduction and cellular radiation responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

The significance of apoptosis in the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Serine/threonine phosphorylation in cytokine signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

c-raf-1 depletion and tumor responses in patients treated with the c-raf-1 antisense oligodeoxynucleotide ISIS 5132 (CGP 69846A).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Hepatocyte growth factor increases in injured organs and functions as an organotrophic factor in rats with experimental acute pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced ce

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Concanavalin A-induced liver injury triggers hepatocyte proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

The Roles of Bile Acids During the Process of Normal Fat and Cholesterol Absorption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Serum Bile Acids in Primary Biliary Cirrhosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

20 June 2018

Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

Activation of constitutive nitric-oxide synthase activity is an early signaling event induced by ionizing radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells.Miko

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153195

26 November 2018

Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of high concentrations of bile acids on cultured hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of the mitochondrial permeability transition as a mechanism of liver injury during cholestasis: a potential role for mitochondrial proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction during liver regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-kappaB, activation protein-1, and c-Jun N-terminal kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB is cleaved by caspases during neural cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Head and neck cancer as a clinical model for molecular targeting of therapy: combining EGFR blockade with radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholecystocolonic fistula: malabsorptive consequences of lost bile acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12697808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Journal of Pharmacology and Experimental Therapeutics

7

272

930

author name string

Botla R.

publication date

1995

1 reference

10.1128/MCB.23.9.3052-3066.2003

https://api.crossref.org/works/10.1128/MCB.23.9.3052-3066.2003

24 December 2023

Signal transduction during liver regeneration

8

1 reference

10.1128/MCB.23.9.3052-3066.2003

https://api.crossref.org/works/10.1128/MCB.23.9.3052-3066.2003

24 December 2023

24

13

194

author name string

Koo M. S.

publication date

2002

1 reference

10.1128/MCB.23.9.3052-3066.2003

https://api.crossref.org/works/10.1128/MCB.23.9.3052-3066.2003

24 December 2023

American Journal of Physiology

28

268

G613

author name string

Kwo P.

publication date

1995

1 reference

10.1128/MCB.23.9.3052-3066.2003

https://api.crossref.org/works/10.1128/MCB.23.9.3052-3066.2003

24 December 2023

American Journal of Physiology

50

271

G293

author name string

Stravitz R. T.

publication date

1996

1 reference

10.1128/MCB.23.9.3052-3066.2003

https://api.crossref.org/works/10.1128/MCB.23.9.3052-3066.2003

24 December 2023

Identifiers

10.1128/MCB.23.9.3052-3066.2003

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

release_723wi2wjjjebxmjv26eyt7vara

1 reference

https://api.fatcat.wiki/v0/release/723wi2wjjjebxmjv26eyt7vara

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

ResearchGate publication ID

0 references

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