(Q36739652)

16 August 2017

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title

Recent advances in growth hormone signaling (English)

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16 August 2017

Nathan J Lanning

1

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PubMed ID

17308965

16 August 2017

Christin Carter-Su

series ordinal

2

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16 August 2017

1 December 2006

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Reviews in Endocrine and Metabolic Disorders

16 August 2017

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16 August 2017

7

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16 August 2017

4

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16 August 2017

225-235

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https://scigraph.springernature.com/pub.10.1007/s11154-007-9025-5

16 August 2017

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cites work

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

1 reference

12 December 2020

Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B

1 reference

12 December 2020

JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone

1 reference

12 December 2020

Simultaneous activation of p90rsk and p70s6k S6 kinases by growth hormone in 3T3-F442A preadipocytes

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12 December 2020

Caveolar and lipid raft localization of the growth hormone receptor and its signaling elements: impact on growth hormone signaling

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12 December 2020

Growth hormone activity in mitochondria depends on GH receptor Box 1 and involves caveolar pathway targeting

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12 December 2020

Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion

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12 December 2020

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

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12 December 2020

Growth hormone receptor expression in the nucleus and cytoplasm of normal and neoplastic cells

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12 December 2020

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

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12 December 2020

Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation

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12 December 2020

Activation of chimeric and full-length growth hormone receptors by growth hormone receptor monoclonal antibodies. A specific conformational change may be required for full-length receptor signaling.

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12 December 2020

Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

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12 December 2020

Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling

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12 December 2020

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.

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12 December 2020

Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

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12 December 2020

Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins

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12 December 2020

Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus

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12 December 2020

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

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12 December 2020

Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling

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12 December 2020

SH2-B is required for growth hormone-induced actin reorganization

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12 December 2020

SH2-Bbeta is a Rac-binding protein that regulates cell motility

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12 December 2020

Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells

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12 December 2020

Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation

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12 December 2020

Identification of the first patient with a confirmed mutation of the JAK-STAT system.

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12 December 2020

Subcellular shift of the hepatic growth hormone receptor with progression of hepatitis C virus-related chronic liver disease

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12 December 2020

Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state

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12 December 2020

Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling

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12 December 2020

Activation of growth hormone receptor delivers an antiapoptotic signal: evidence for a role of Akt in this pathway

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12 December 2020

Src transduces signaling via growth hormone (GH)-activated GH receptor (GHR) tyrosine-phosphorylating GHR and STAT5 in human leukemia cells

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12 December 2020

Identification of a JAK2-independent pathway regulating growth hormone (GH)-stimulated p44/42 mitogen-activated protein kinase activity. GH activation of Ral and phospholipase D is Src-dependent

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12 December 2020

Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha

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12 December 2020

Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation

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12 December 2020

Growth hormone stimulates the tyrosine phosphorylation of 42- and 45-kDa ERK-related proteins

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12 December 2020

Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation

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12 December 2020

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

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12 December 2020

Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins

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12 December 2020

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

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12 December 2020

Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat

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12 December 2020

Inadequacy of the Janus kinase 2/signal transducer and activator of transcription signal transduction pathway to mediate episodic growth hormone-dependent regulation of hepatic CYP2C11.

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12 December 2020

Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling

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12 December 2020

Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling

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12 December 2020

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

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12 December 2020

Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis

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12 December 2020

Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).

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12 December 2020

SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms

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12 December 2020

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

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12 December 2020

Cellular trafficking of exogenous growth hormone in dwarf rat pituitary.

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12 December 2020

Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein

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12 December 2020

Growth hormone-induced tyrosyl phosphorylation and deoxyribonucleic acid binding activity of Stat5A and Stat5B.

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12 December 2020

Growth hormone regulation of sex-dependent liver gene expression

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12 December 2020

Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization

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12 December 2020

Negative regulation of growth hormone receptor signaling.

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12 December 2020

Binding in the growth hormone receptor complex

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12 December 2020

Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation

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12 December 2020

Characterization of distinct Stat5b binding sites that mediate growth hormone-stimulated IGF-I gene transcription

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12 December 2020

Kinase activation through dimerization by human SH2-B

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12 December 2020

Endocytosis and degradation of the growth hormone receptor are proteasome-dependent

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12 December 2020

Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2

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12 December 2020

The role of STAT proteins in growth hormone signaling

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12 December 2020

Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis

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12 December 2020

Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.

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12 December 2020

Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription

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12 December 2020

Signal transduction via the growth hormone receptor

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12 December 2020

Retinal ganglion cell survival in development: mechanisms of retinal growth hormone action.

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12 December 2020

Mapping of a cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins

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12 December 2020

ErbB receptors: new insights on mechanisms and biology

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12 December 2020

Growth hormone-induced reorganization of the actin cytoskeleton is not required for STAT5 (signal transducer and activator of transcription-5)-mediated transcription

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12 December 2020

CrkII participation in the cellular effects of growth hormone and insulin-like growth factor-1. Phosphatidylinositol-3 kinase dependent and independent effects

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12 December 2020

Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor.

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12 December 2020

Dual regulation of phosphorylation and dephosphorylation of C/EBPbeta modulate its transcriptional activation and DNA binding in response to growth hormone

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12 December 2020

Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity

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12 December 2020

Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia

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12 December 2020

Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

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12 December 2020

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

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12 December 2020

Receptor-mediated nuclear translocation of growth hormone.

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12 December 2020

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes

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12 December 2020

Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor

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12 December 2020

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase

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12 December 2020

Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta

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12 December 2020

Growth hormone/JAK-STAT axis signal-transduction defect. A novel treatable cause of growth failure.

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12 December 2020

Effect of growth hormone on the translocation of GLUT4 and its relation to insulin-like and anti-insulin action

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12 December 2020

Downregulation of the growth hormone-induced Janus kinase 2/signal transducer and activator of transcription 5 signaling pathway requires an intact actin cytoskeleton.

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12 December 2020

Localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate

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12 December 2020

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

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12 December 2020

The conserved box 1 motif of cytokine receptors is required for association with JAK kinases

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12 December 2020

Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK

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12 December 2020

Gigantism in mice lacking suppressor of cytokine signalling-2

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12 December 2020

Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways

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12 December 2020

Src-CrkII-C3G-dependent Activation of Rap1 Switches Growth Hormone-stimulated p44/42 MAP Kinase and JNK/SAPK Activities

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12 December 2020

Growth hormone promotion of tubulin polymerization stabilizes the microtubule network and protects against colchicine-induced apoptosis

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12 December 2020

Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B

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12 December 2020

The role of C/EBP genes in adipocyte differentiation.

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12 December 2020

Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor

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12 December 2020

SOCS3 negatively regulates IL-6 signaling in vivo

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12 December 2020

10.1007/S11154-007-9025-5

Identifiers

DOI

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16 August 2017

1 reference

PubMed ID

17308965