(Q36743584)

English

Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function

scientific article published on March 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

16 August 2017

Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function (English)

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Europe PubMed Central

PMC publication ID

16 August 2017

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26938530%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Courtney Nicholas

3

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31 May 2020

Martha-Elba González-Mejía

8

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31 May 2020

Erich Grotewold

10

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31 May 2020

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Horacio Cardenas

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31 May 2020

Silvia Duarte

4

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31 May 2020

Gerard J Nuovo

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31 May 2020

Wei He

6

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31 May 2020

Oliver H Voss

7

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31 May 2020

Denis C Guttridge

9

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31 May 2020

Andrea I Doseff

11

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31 May 2020

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publication date

1 March 2016

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16 August 2017

International Journal of Molecular Sciences

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31 May 2020

17

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31 May 2020

3

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31 May 2020

323

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31 May 2020

copyright license

Creative Commons Attribution 4.0 International

1 March 2016

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April 2022 Public Data File from Crossref

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0 references

Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Apigenin protects endothelial cells from lipopolysaccharide (LPS)-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

1 reference

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29 September 2017

Flavone deglycosylation increases their anti-inflammatory activity and absorption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

NF-κB, inflammation, and metabolic disease.

1 reference

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29 September 2017

IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)

1 reference

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29 September 2017

Survival in critical illness is associated with early activation of mitochondrial biogenesis

1 reference

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29 September 2017

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease.

1 reference

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29 September 2017

Inhibition of LPS-induced pulmonary inflammation by specific flavonoids

1 reference

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29 September 2017

Pharmacotherapy of acute lung injury and acute respiratory distress syndrome

1 reference

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29 September 2017

Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Shared principles in NF-kappaB signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Acute lung injury and cell death: how many ways can cells die?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Vascular biology in sepsis: pathophysiological and therapeutic significance of vascular dysfunction

1 reference

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29 September 2017

Metabolic support in sepsis and multiple organ failure: more questions than answers ...

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Clara cells impact the pulmonary innate immune response to LPS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Apoptosis and caspases regulate death and inflammation in sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Dampening inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Transcriptional profiling of lipopolysaccharide-induced acute lung injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

The pathophysiology and treatment of sepsis

1 reference

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29 September 2017

Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury

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29 September 2017

The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense.

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29 September 2017

Regulation of experimental lung inflammation

1 reference

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29 September 2017

Apoptosis in sepsis: a new target for therapeutic exploration

1 reference

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29 September 2017

The biology of Toll-like receptors

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Prevention of lymphocyte cell death in sepsis improves survival in mice

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Protein tyrosine kinase inhibitors as novel therapeutic agents

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29 September 2017

Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis

1 reference

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29 September 2017

Elevated levels of macrophage inflammatory protein 2 in severe murine peritonitis increase neutrophil recruitment and mortality

1 reference

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29 September 2017

Lipopolysaccharide-induced apoptosis in swine lymphocytes in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

Endotoxin and lung injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

29 September 2017

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1 reference

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29 September 2017

Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

28 June 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

28 June 2018

Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

5 September 2018

A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with their putative targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

5 September 2018

Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

5 September 2018

Inhibition of nuclear factor-kappaB activation by 2',8''-biapigenin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

5 September 2018

15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

5 September 2018

Tumor necrosis factor-alpha-induced caspase activation mediates endotoxin-related cardiac dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

5 September 2018

Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4813185

5 September 2018

Recombinant production and biological properties of rat cytokine-induced neutrophil chemoattractants, GRO/CINC-2 alpha, CINC-2 beta and CINC-3.

1 reference

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5 September 2018

In-vivo induction of apoptosis in murine lymphocytes by bacterial lipopolysaccharides.

1 reference

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5 September 2018

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1 reference

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20 October 2018

In vivo imaging of NF-kappa B activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26938530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutrophil chemoattractant genes KC and MIP-2 are expressed in different cell populations at sites of surgical injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/26938530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralization of macrophage inflammatory protein-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26938530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for macrophage inflammatory protein-2 in lipopolysaccharide-induced lung injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26938530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment

1 reference

https://pubmed.ncbi.nlm.nih.gov/26938530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutrophil recruitment and increased permeability during acute lung injury induced by lipopolysaccharide

1 reference

https://pubmed.ncbi.nlm.nih.gov/26938530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ventricular Myocyte Caspases Are Directly Responsible for Endotoxin-Induced Cardiac Dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/26938530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/26938530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/26938530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/26938530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/26938530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/IJMS17030323

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26938530%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26938530%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26938530%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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