(Q36622618)

15 August 2017

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title

Apoptosis and caspases regulate death and inflammation in sepsis (English)

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15 August 2017

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1

Richard S Hotchkiss

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15 August 2017

Donald W Nicholson

2

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15 August 2017

publication date

13 October 2006

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Nature Reviews Immunology

15 August 2017

published in

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15 August 2017

volume

6

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15 August 2017

issue

11

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15 August 2017

page(s)

813-822

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Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine

15 August 2017

cites work

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CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance

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Death-defying immunity: do apoptotic cells influence antigen processing and presentation?

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Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options

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The role of BH3-only proteins in the immune system

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Cell death: critical control points

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Molecular mechanisms of apoptosis in the cells of the immune system in human aging

21 January 2018

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

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Caspase activation is not death

21 January 2018

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Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system

21 January 2018

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Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis.

21 January 2018

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Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity

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In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice

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Increased lymphoid tissue apoptosis in baboons with bacteremic shock

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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Caspase structure, proteolytic substrates, and function during apoptotic cell death

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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

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Protease activation during apoptosis: death by a thousand cuts?

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Tumor necrosis factor-alpha-induced caspase activation mediates endotoxin-related cardiac dysfunction.

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Caspase inhibition prevents cardiac dysfunction and heart apoptosis in a rat model of sepsis.

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Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitor

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Acute renal failure in endotoxemia is dependent on caspase activation

21 January 2018

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An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12

21 January 2018

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

21 January 2018

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Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

21 January 2018

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Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

21 January 2018

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Transient Bcl-2 gene down-expression in circulating mononuclear cells of severe sepsis patients who died despite appropriate intensive care

21 January 2018

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Akt decreases lymphocyte apoptosis and improves survival in sepsis

21 January 2018

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Leukocyte apoptosis and its significance in sepsis and shock

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Neuroprotection by a caspase inhibitor in acute bacterial meningitis

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Prevention of lymphocyte cell death in sepsis improves survival in mice

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Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

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Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics

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Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

21 January 2018

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Caspase-8 serves both apoptotic and nonapoptotic roles

21 January 2018

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Specific involvement of caspases in the differentiation of monocytes into macrophages

21 January 2018

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Caspase activity is required for stimulated B lymphocytes to enter the cell cycle

21 January 2018

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Apoptosis in the development and maintenance of the immune system

21 January 2018

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Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

21 January 2018

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Caspases and nitric oxide broadly regulate dendritic cell maturation and surface expression of class II MHC proteins

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Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2.

21 January 2018

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Caspase-independent cell death

21 January 2018

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Caspase-independent cell death in T lymphocytes

21 January 2018

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Do inducers of apoptosis trigger caspase-independent cell death?

21 January 2018

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The pathophysiology of mitochondrial cell death

21 January 2018

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Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

21 January 2018

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Four deaths and a funeral: from caspases to alternative mechanisms.

21 January 2018

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Modulation of apoptosis by HIV protease inhibitors

21 January 2018

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Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death.

21 January 2018

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Antiapoptotic mechanism of HIV protease inhibitors: preventing mitochondrial transmembrane potential loss

21 January 2018

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Improved survival in experimental sepsis with an orally administered inhibitor of apoptosis

21 January 2018

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Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor

21 January 2018

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Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis

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Recent advances in understanding the cell death pathways activated by anticancer therapy

21 January 2018

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Programmed cell death: many ways for cells to die decently.

21 January 2018

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Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

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From bench to clinic with apoptosis-based therapeutic agents

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Pathogen recognition and innate immunity

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Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival

21 January 2018

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In vivo protein transduction: delivery of a biologically active protein into the mouse

21 January 2018

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Intravenous TAT-Bcl-Xl is protective after middle cerebral artery occlusion in mice

21 January 2018

1 reference

BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo

21 January 2018

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Protein transduction technology offers novel therapeutic approach for brain ischemia

21 January 2018

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Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

21 January 2018

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Immunosuppressive effects of apoptotic cells

21 January 2018

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21 January 2018

Gone but not forgotten

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Animal models of sepsis and shock: a review and lessons learned.

21 January 2018

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Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group

31 March 2020

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Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment

31 March 2020

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31 March 2020

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Monocyte deactivation in septic patients: restoration by IFN-gamma treatment

31 March 2020

1 reference

Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway

31 March 2020

1 reference

Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis?

31 March 2020

1 reference

Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis

31 March 2020

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Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans

31 March 2020

1 reference

Depletion of dendritic cells, but not macrophages, in patients with sepsis

31 March 2020

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Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure

31 March 2020

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Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome

31 March 2020

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Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways

31 March 2020

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The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration

31 March 2020

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Caspase-activation pathways in apoptosis and immunity

31 March 2020

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Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis

31 March 2020

1 reference

Ventricular Myocyte Caspases Are Directly Responsible for Endotoxin-Induced Cardiac Dysfunction

31 March 2020

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Over-expression of Bcl-2 provides protection in septic mice by a trans effect

31 March 2020

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Endotoxic shock leads to apoptosis in vivo and reduces Bcl-2

31 March 2020

1 reference

In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis

31 March 2020

1 reference

TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo

31 March 2020

1 reference

The effects of injury on the adaptive immune response

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1943

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Dimensions Publication ID

15 August 2017

1033337136

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