(Q35116688)

6 August 2017

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title

Caspase-independent cell death in T lymphocytes (English)

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6 August 2017

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2

Jürg Tschopp

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6 August 2017

Marja Jäättelä

1

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ORCID Public Data File 2021

language of work or name

English

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publication date

1 May 2003

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6 August 2017

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6 August 2017

4

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6 August 2017

416-423

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6 August 2017

5

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

6 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

https://api.crossref.org/works/10.1038%2FNI0503-416

1 reference

7 January 2021

Programmed cell death: alive and well in the new millennium

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Four deaths and a funeral: from caspases to alternative mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Caspase-independent cell deaths

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https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Caspase activation without death

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https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Apoptosis: cell death defined by caspase activation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Programmed cell death and apoptosis: origins of the theory.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease?

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Organelle-specific initiation of cell death pathways

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Triggering caspase-independent cell death to combat cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

The 'harmless' release of cytochrome c.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Dueling activities of AIF in cell death versus survival: DNA binding and redox activity

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Endonuclease G is an apoptotic DNase when released from mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

The mitochondrial permeability transition initiates autophagy in rat hepatocytes.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

An alternative, nonapoptotic form of programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Apoptosis in neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Cathepsins as effector proteases in hepatocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Lysosomal destabilization in p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

B cell receptor-stimulated mitochondrial phospholipase A2 activation and resultant disruption of mitochondrial membrane potential correlate with the induction of apoptosis in WEHI-231 B cells.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Non-specific effects of methyl ketone peptide inhibitors of caspases

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Autophagy in the eukaryotic cell

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Calpain and caspase: can you tell the difference?

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Sensitization to TNF-induced apoptosis by 1,25-dihydroxy vitamin D3 involves up-regulation of the TNF receptor 1 and cathepsin B

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

The molecular architecture of the TNF superfamily

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

The TNF and TNF receptor superfamilies: integrating mammalian biology

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Death receptors: signaling and modulation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Caspase activation: the induced-proximity model

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Regulation of lymphocyte proliferation and death by FLIP.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

TNF-R1 signaling: a beautiful pathway

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Sensitization to death receptor cytotoxicity by inhibition of fas-associated death domain protein (FADD)/caspase signaling. Requirement of cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Resistance to the cytotoxic effects of tumor necrosis factor alpha can be overcome by inhibition of a FADD/caspase-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Differential sensitivity of Jurkat and primary T cells to caspase-independent cell death triggered upon Fas stimulation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Caspase-independent cell killing by Fas-associated protein with death domain

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Redox regulation of TNF signaling

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Phospholipase A2 enzymes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

cPLA2 is phosphorylated and activated by MAP kinase

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Tumour necrosis factor-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 are abrogated by an inhibitor of the p38 mitogen-activated protein kinase cascade in human neutrophils

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Regulation of ceramide production and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Role of caspases in TNF-mediated regulation of cPLA(2).

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Inhibition of NFkappaB induces caspase-independent cell death in human T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Caspase-independent apoptotic pathways in T lymphocytes: a minireview

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

CD99 signals caspase-independent T cell death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Caspase enzyme activity is not essential for apoptosis during thymocyte development

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Induction of apoptosis in mature T cells by tumour necrosis factor

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Apoptosis signaling in lymphocytes.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Fas and Fas ligand: lpr and gld mutations

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

T cell receptor ligation triggers novel nonapoptotic cell death pathways that are Fas-independent or Fas-dependent

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Caspase-independent phosphatidylserine exposure during apoptosis of primary T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Caspase activation is required for T cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-416

7 January 2021

Identifiers

DOI

10.1038/NI0503-416

1 reference

6 August 2017

1 reference

PubMed ID

12719731