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Triggering caspase-independent cell death to combat cancer.
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12067630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067630%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
Triggering caspase-independent cell death to combat cancer
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12067630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067630%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
main subject
cell death
1 reference
based on heuristic
inferred from title
author
Marja Jäättelä
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12067630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067630%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
author name string
Ida S Mathiasen
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12067630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067630%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
publication date
1 May 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
12067630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067630%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
published in
Trends in Molecular Medicine
1 reference
stated in
Europe PubMed Central
PubMed ID
12067630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067630%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
volume
8
1 reference
stated in
Europe PubMed Central
PubMed ID
12067630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067630%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
page(s)
212-220
1 reference
stated in
Europe PubMed Central
PubMed ID
12067630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067630%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
issue
5
1 reference
stated in
Europe PubMed Central
PubMed ID
12067630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067630%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
cites work
Programmed cell death: alive and well in the new millennium
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Organelle-specific initiation of cell death pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-independent programmed cell death with necrotic morphology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Four deaths and a funeral: from caspases to alternative mechanisms.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Escaping cell death: survival proteins in cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proliferation, cell cycle and apoptosis in cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis-regulating proteins as targets for drug discovery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Strategies for immunotherapy of cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of death receptor signals by cellular FLIP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defects in the ubiquitin pathway induce caspase-independent apoptosis blocked by Bcl-2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cathepsins as effector proteases in hepatocyte apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An alternative, nonapoptotic form of programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Triggering of apoptosis by cathepsins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Noncaspase proteases in apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Calpain and caspase: can you tell the difference?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of calpain in caspase activation during etoposide induced apoptosis in T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Calpain activation is upstream of caspases in radiation-induced apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lysosomal cysteine proteases: facts and opportunities
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cathepsin D targeted by acid sphingomyelinase-derived ceramide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sphingosine-induced apoptosis is dependent on lysosomal proteases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granule-mediated killing: pathways for granzyme B-initiated apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemotherapeutic drug activation of the AP24 protease in apoptosis: requirement for caspase 3-like-proteases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
L-DNase II, a molecule that links proteases and endonucleases in apoptosis, derives from the ubiquitous serpin leukocyte elastase inhibitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ca(2+)-induced inhibition of apoptosis in human SH-SY5Y neuroblastoma cells: degradation of apoptotic protease activating factor-1 (APAF-1).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The 'harmless' release of cytochrome c.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endonuclease G is an apoptotic DNase when released from mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resistance to the cytotoxic effects of tumor necrosis factor alpha can be overcome by inhibition of a FADD/caspase-dependent signaling pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A kinase-independent function of Ask1 in caspase-independent cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heat shock protein 70 is required for the survival of cancer cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PML induces a novel caspase-independent death process
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling pathways in apoptosis as potential targets for cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD99 signals caspase-independent T cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902328-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1471-4914(02)02328-6
1 reference
stated in
Europe PubMed Central
PubMed ID
12067630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067630%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
PubMed ID
12067630
1 reference
stated in
Europe PubMed Central
PubMed ID
12067630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067630%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
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