(Q36748125)

16 August 2017

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title

Considerations in the rational design and conduct of phase I/II pediatric clinical trials: avoiding the problems and pitfalls (English)

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16 August 2017

main subject

phase I clinical trial

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phase II clinical trial

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4

Kearns GL

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16 August 2017

Abdel-Rahman SM

1

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16 August 2017

Reed MD

series ordinal

2

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16 August 2017

Wells TG

series ordinal

3

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16 August 2017

language of work or name

English

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publication date

28 February 2007

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Clinical Pharmacology & Therapeutics

16 August 2017

published in

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16 August 2017

volume

81

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16 August 2017

issue

4

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16 August 2017

page(s)

483-494

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Peer-reviewed publication of clinical trials completed for pediatric exclusivity

16 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

Ontogeny of drug metabolizing enzymes in the neonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

Pharmacokinetic variability in the adolescent: implications of body size and organ function for dosage regimen design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

Influence of menstrual cycle on the pharmacokinetics of paracetamol through salivary compartment in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

Correlative study of hydrochloric acid, pepsin, and intrinsic factor secretion in newborns and infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

The pharmacokinetics and analgesic efficacy of larger dose rectal acetaminophen (40 mg/kg) in adults: a double-blinded, randomized study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

Direct comparison of skin physiology in children and adults with bioengineering methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

The influence of age on the activity of acetylsalicylic acid-esterase and protein-salicylate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

Assessing distress in pediatric intensive care environments: the COMFORT scale

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part I).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Comparison of serum levels following the administration of oral and parenteral preparations of penicillin to infants and children of various age groups

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https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Single dose pharmacokinetics of pleconaril in neonates. Pediatric Pharmacology Research Unit Network

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7 January 2021

Age-related changes in colon motility

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https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Multiple-dose pharmacokinetics of rectally administered acetaminophen in term infants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Relative bioavailability and plasma paracetamol profiles of Panadol suppositories in children

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https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Percutaneous drug absorption in the newborn: hazards and uses.

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https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Developmental aspects of percutaneous caffeine absorption in premature infants

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https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Single dose pharmacokinetics of linezolid in infants and children.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Impact of ontogeny on linezolid disposition in neonates and infants

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https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Gestational evolution of small intestine motility in preterm and term infants.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Postnatal hemodynamic changes in very-low-birthweight infants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Mesenteric blood flow velocity and its relation to transitional circulatory adaptation in appropriate for gestational age preterm infants

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7 January 2021

Mesenteric blood flow velocity and its relation to circulatory adaptation during the first week of life in healthy term infants.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Distribution of capillaries in normal and diseased human skeletal muscle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Pharmacokinetics of amikacin in infants and pre-school children

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Are postoperative pain instruments useful for specific groups of vulnerable infants?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Optimal sedation of mechanically ventilated pediatric critical care patients.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Clinical trial design issues: at least 10 things you should look for in clinical trials

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Omeprazole disposition in children following single-dose administration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Development of feeding practices during the first 5 years of life

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100134

7 January 2021

Identifiers

DOI

10.1038/SJ.CLPT.6100134

1 reference

16 August 2017

1 reference