(Q36760050)

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Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.

scientific article published on 26 January 2016

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6 March 2020

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI (English)

1 reference

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6 March 2020

Cassie M Jarvis

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6 March 2020

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6 March 2020

James W. Janetka

12

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6 March 2020

Scott J. Hultgren

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Scott J Hultgren

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6 March 2020

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Zhenfu Han

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6 March 2020

Vasilios Kalas

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6 March 2020

Roger Klein

4

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6 March 2020

Jerome S Pinkner

5

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6 March 2020

Jana Binkley

7

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6 March 2020

Corinne K Cusumano

8

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Zachary Cusumano

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6 March 2020

Laurel Mydock-McGrane

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6 March 2020

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26 January 2016

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6 March 2020

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6 March 2020

11

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6 March 2020

4

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6 March 2020

367-373

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6 March 2020

Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.

1 reference

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The tyrosine gate of the bacterial lectin FimH: a conformational analysis by NMR spectroscopy and X-ray crystallography

1 reference

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1 reference

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FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile

1 reference

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A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131.

1 reference

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Structural and energetic basis of folded-protein transport by the FimD usher

1 reference

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Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.

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FimH antagonists: structure-activity and structure-property relationships for biphenyl α-D-mannopyranosides

1 reference

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29 September 2017

Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides

1 reference

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29 September 2017

Treatment and prevention of urinary tract infection with orally active FimH inhibitors

1 reference

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29 September 2017

Insights into a multidrug resistant Escherichia coli pathogen of the globally disseminated ST131 lineage: genome analysis and virulence mechanisms

1 reference

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29 September 2017

Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection

1 reference

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29 September 2017

Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists

1 reference

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29 September 2017

Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics

1 reference

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29 September 2017

Anti-virulence strategies to combat bacteria-mediated disease

1 reference

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29 September 2017

Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818977

29 September 2017

Molecular characterization of the Escherichia coli FimH adhesin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818977

29 September 2017

X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli

1 reference

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29 September 2017

Aromatic alpha-glycosides of mannose are powerful inhibitors of the adherence of type 1 fimbriated Escherichia coli to yeast and intestinal epithelial cells

1 reference

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29 September 2017

FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation.

1 reference

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28 June 2018

Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists

1 reference

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5 September 2018

Epidemiology of urinary tract infections: incidence, morbidity, and economic costs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201600006

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure, function, and assembly of type 1 fimbriae

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201600006

7 January 2021

based on heuristic

inferred from DOI database lookup

Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201600006

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CMDC.201600006

1 reference

Europe PubMed Central

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6 March 2020

1 reference

Europe PubMed Central

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6 March 2020

1 reference

Europe PubMed Central

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6 March 2020

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