(Q36767295)

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IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells.

scientific article published on 12 February 2013

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23 February 2020

IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells (English)

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23 February 2020

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23 February 2020

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Carl H June

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23 February 2020

Saskia J A M Santegoets

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Saskia J A M Santegoets

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ORCID Public Data File 2021

Tanja D de Gruijl

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Tanja D de Gruijl

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23 February 2020

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Annelies W Turksma

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23 February 2020

Megan M Suhoski

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23 February 2020

Anita G M Stam

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23 February 2020

Steve M Albelda

5

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23 February 2020

Rik J Scheper

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23 February 2020

Alfons J M van den Eertwegh

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23 February 2020

Winald R Gerritsen

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23 February 2020

Daniel J Powell

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23 February 2020

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12 February 2013

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23 February 2020

Journal of Translational Medicine

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23 February 2020

11

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23 February 2020

37

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23 February 2020

copyright license

Creative Commons Attribution 2.0 Generic

12 February 2013

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copyright status

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https://scigraph.springernature.com/pub.10.1186/1479-5876-11-37

0 references

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

1 reference

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29 September 2017

Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes

1 reference

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29 September 2017

Role of common-gamma chain cytokines in NK cell development and function: perspectives for immunotherapy.

1 reference

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29 September 2017

Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy

1 reference

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29 September 2017

Establishment and large-scale expansion of minimally cultured "young" tumor infiltrating lymphocytes for adoptive transfer therapy

1 reference

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29 September 2017

CD8+ enriched "young" tumor infiltrating lymphocytes can mediate regression of metastatic melanoma

1 reference

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29 September 2017

Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients

1 reference

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29 September 2017

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1 reference

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29 September 2017

Combination of IL-21 and IL-15 enhances tumour-specific cytotoxicity and cytokine production of TCR-transduced primary T cells

1 reference

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29 September 2017

Differential effects of IL-2 and IL-21 on expansion of the CD4+ CD25+ Foxp3+ T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic lymphocytic leukemia

1 reference

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29 September 2017

New insights into the regulation of T cells by gamma(c) family cytokines

1 reference

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29 September 2017

Replicative potential of human natural killer cells

1 reference

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29 September 2017

Adoptive cell therapy for the treatment of patients with metastatic melanoma

1 reference

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29 September 2017

Minimally cultured tumor-infiltrating lymphocytes display optimal characteristics for adoptive cell therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626797

29 September 2017

Overcoming obstacles to the effective immunotherapy of human cancer

1 reference

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29 September 2017

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

1 reference

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29 September 2017

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626797

29 September 2017

IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626797

29 September 2017

Interleukin-21: a new modulator of immunity, infection, and cancer

1 reference

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29 September 2017

Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626797

29 September 2017

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

1 reference

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29 September 2017

Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy

1 reference

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29 September 2017

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

1 reference

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29 September 2017

IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients

1 reference

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29 September 2017

Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy.

1 reference

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29 September 2017

IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response

1 reference

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29 September 2017

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

1 reference

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29 September 2017

Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy

1 reference

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29 September 2017

Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626797

29 September 2017

IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21

1 reference

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IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

1 reference

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29 September 2017

Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients

1 reference

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29 September 2017

Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.

1 reference

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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

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1 reference

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Characterization of CD4+CD25+ regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma

1 reference

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Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-11-37

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https://api.crossref.org/works/10.1186%2F1479-5876-11-37

21 January 2018

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23402380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skin tests predict survival after autologous tumor cell vaccination in metastatic melanoma: experience in 81 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/23402380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/23402380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23402380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1479-5876-11-37

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23 February 2020

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Europe PubMed Central

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23 February 2020

1 reference

Europe PubMed Central

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23 February 2020

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