(Q36777966)

16 August 2017

The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition (English)

1 reference

16 August 2017

1 reference

Zhu-li Wan

1

1 reference

16 August 2017

Kun Huang

2

1 reference

16 August 2017

Shi-Quan Hu

3

1 reference

16 August 2017

Jonathan Whittaker

4

1 reference

16 August 2017

Michael A Weiss

5

1 reference

16 August 2017

language of work or name

English

0 references

publication date

20 May 2008

1 reference

16 August 2017

13

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

16 August 2017

283

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16 August 2017

21198-21210

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16 August 2017

30

1 reference

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Insulin gene mutations as a cause of permanent neonatal diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Insulin glulisine complementing basal insulins: a review of structure and activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Proinsulin is refractory to protein fibrillation: topological protection of a precursor protein from cross-beta assembly

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

A single amino acid substitution in the active site of Escherichia coli aspartate transcarbamoylase prevents the allosteric transition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Characterization of the functional insulin binding epitopes of the full-length insulin receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

A formula for correlating pKa values determined in D2O and H2O.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Crystal Structure ofallo-IleA2-Insulin, an Inactive Chiral Analogue: Implications for the Mechanism of Receptor Binding,

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Structural biology of insulin and IGF1 receptors: implications for drug design

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Insulin at pH 2: structural analysis of the conditions promoting insulin fibre formation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Evolution of the insulin molecule: insights into structure-activity and phylogenetic relationships

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Application of circular dichroism to study RNA folding transitions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 pro --> Asp insulin analogues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

The role of assembly in insulin's biosynthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Solution structure of an engineered insulin monomer at neutral pH

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Crystallographic evidence for dual coordination around zinc in the T3R3 human insulin hexamer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Insulin synthesis by recombination of A and B chains: a highly efficient method

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Weakly polar interactions in proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

The structure of 2Zn pig insulin crystals at 1.5 A resolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Cloning of complementary DNAs encoding islet amyloid polypeptide, insulin, and glucagon precursors from a New World rodent, the degu, Octodon degus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Improved methods for building protein models in electron density maps and the location of errors in these models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Receptor binding redefined by a structural switch in a mutant human insulin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Insulin hexamers: new conformations and applications

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Structure and dynamics of des-pentapeptide-insulin in solution: the molten-globule hypothesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Three-dimensional solution structure of an insulin dimer. A study of the B9(Asp) mutant of human insulin using nuclear magnetic resonance, distance geometry and restrained molecular dynamics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Structure of insulin in 4-zinc insulin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Regulation of Oxygen Affinity of Hemoglobin: Influence of Structure of the Globin on the Heme Iron

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Hemoglobin Abruzzo (beta143 (H21) His replaced by Arg). Consequences of altering the 2,3-diphosphoglycerate binding site

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Receptor-binding region of insulin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Hemoglobin Deer Lodge (beta 2 His replaced by Arg). Consequences of altering the 2,3-diphosphoglycerate binding site

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

The stereochemical mechanism of the cooperative effects in hemoglobin revisited.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Toward understanding insulin fibrillation

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Coypu insulin. Primary structure, conformation and biological properties of a hystricomorph rodent insulin

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Spectroscopic signatures of the T to R conformational transition in the insulin hexamer.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Hypoglycemic potency and metabolic clearance rate of intravenously administered human proinsulin and metabolites.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Amino acid sequence from degu islet amyloid-derived insulin shows unique sequence characteristics.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Allosteric interactions in non-alpha chains isolated from normal human hemoglobin, fetal hemoglobin, and hemoglobin Abruzzo (beta143 (H21) His replaced by Arg)

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

27 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800235200

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800235200

Structural details of Asp(B9) human insulin at low pH from two-dimensional NMR titration studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800235200

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800235200

Crystallization and preliminary crystallographic investigation of a low-pH native insulin monomer with flexible behaviour.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475698

Reactions between nitric oxide and haemoglobin under physiological conditions

5 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800235200

Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800235200

Transmission of conformational change in insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800235200

Comparative 2D NMR studies of human insulin and des-pentapeptide insulin: sequential resonance assignment and implications for protein dynamics and receptor recognition

21 January 2018

1 reference

12 December 2020

Two-dimensional NMR studies of Des-(B26-B30)-insulin: sequence-specific resonance assignments and effects of solvent composition

1 reference

12 December 2020

Implications of invariant residue LeuB6 in insulin-receptor interactions

1 reference

12 December 2020

Kinetic Measurements of T→ R Structural Transitions in Insulin

1 reference

12 December 2020

Importance of aliphatic side-chain structure at positions 2 and 3 of the insulin A chain in insulin-receptor interactions

1 reference

12 December 2020

Dynamics of a monomeric insulin analogue: testing the molten-globule hypothesis

1 reference

12 December 2020

Steric requirements at position B12 for high biological activity in insulin

1 reference

12 December 2020

Action profile of the rapid acting insulin analogue: human insulin B28Asp

1 reference

12 December 2020

An insulin with the native sequence but virtually no activity

1 reference

12 December 2020

A proposed interaction model of the insulin molecule with its receptor

1 reference

12 December 2020

Structure and dynamics of a protein assembly. 1H-NMR studies of the 36 kDa R6 insulin hexamer

1 reference

12 December 2020

Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain

1 reference

12 December 2020

A comparison of the dynamic behavior of monomeric and dimeric insulin shows structural rearrangements in the active monomer

1 reference

12 December 2020

Mutational analysis of invariant valine B12 in insulin: implications for receptor binding

1 reference

12 December 2020

Structural and functional studies of hemoglobin Suresnes (arg 141 alpha 2 replaced by His beta 2). Consequences of disrupting an oxygen-linked anion-binding site

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M800235200

1 reference

16 August 2017

1 reference

16 August 2017

1 reference