(Q27648393)

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The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice

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The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice (English)

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1 reference

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Pierre De Meyts

object named as

Pierre De Meyts

9

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author name string

Kun Huang

1

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Shu Jin Chan

2

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Qing-xin Hua

3

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Ying-Chi Chu

4

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Run-ying Wang

5

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Birgit Klaproth

6

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Wenhua Jia

7

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Jonathan Whittaker

8

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Satoe H Nakagawa

10

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Donald F Steiner

11

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Panayotis G Katsoyannis

12

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Michael A Weiss

13

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language of work or name

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publication date

30 November 2007

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Journal of Biological Chemistry

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282

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48

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35337-49

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Structure of the insulin receptor ectodomain reveals a folded-over conformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

The role of assembly in insulin's biosynthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Three mutant insulins in man

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Receptor binding redefined by a structural switch in a mutant human insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

A structural switch in a mutant insulin exposes key residues for receptor binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Diabetes-associated mutations in insulin identify invariant receptor contacts.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Photoaffinity Labeling of Biological Systems

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Mutational analysis of the three conserved valine residues of insulin and a proposal of "isosteric residue".

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affinity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Target-directed proteolysis at the ribosome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Characterization of the functional insulin binding epitopes of the full-length insulin receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Synthesis of the antibacterial peptide cecropin A (1-33).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Insulin-like compounds related to the amphioxus insulin-like peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Activities of monomeric insulin analogs at position A8 are uncorrelated with their thermodynamic stabilities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Application of circular dichroism to study RNA folding transitions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

SURFNET: a program for visualizing molecular surfaces, cavities, and intermolecular interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Characterization of the insulin and somatomedin-C receptors in human placental cell membranes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Insulin interactions with its receptors: experimental evidence for negative cooperativity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Isosteric replacement of A3 Val of porcine insulin by allo-Thr

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Structural biology of insulin and IGF1 receptors: implications for drug design

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

N- and C-capping preferences for all 20 amino acids in alpha-helical peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Aromatic-aromatic interaction: a mechanism of protein structure stabilization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Stability of alpha-helices

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Alpha-helix stabilization by natural and unnatural amino acids with alkyl side chains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Hydrophobicity regained.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Stabilization of local structures by pi-CH and aromatic-backbone amide interactions involving prolyl and aromatic residues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

In vitro refolding of human proinsulin. Kinetic intermediates, putative disulfide-forming pathway folding initiation site, and potential role of C-peptide in folding process

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Insulin gene mutations as a cause of permanent neonatal diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Crystal Structure ofallo-IleA2-Insulin, an Inactive Chiral Analogue: Implications for the Mechanism of Receptor Binding,

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors. Insights into mechanisms of ligand binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Protein volume in solution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705996200

21 January 2018

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10.1074/JBC.M705996200

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