(Q36778839)

16 August 2017

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title

Brain iron toxicity: differential responses of astrocytes, neurons, and endothelial cells (English)

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16 August 2017

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Julie A Gaasch

1

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16 August 2017

Paul R Lockman

2

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16 August 2017

Werner J Geldenhuys

3

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16 August 2017

David D Allen

4

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16 August 2017

Cornelis J Van der Schyf

5

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16 August 2017

publication date

3 April 2007

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16 August 2017

published in

Neurochemical Research

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16 August 2017

volume

32

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16 August 2017

issue

7

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16 August 2017

page(s)

1196-1208

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Heme and iron metabolism: role in cerebral hemorrhage

16 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS11064-007-9290-4

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Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9290-4

21 January 2018

Brain iron homeostasis

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12 December 2020

Iron metabolism and its regulation. A review

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Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies

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12 December 2020

Identification of a novel route of iron transcytosis across the mammalian blood-brain barrier

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12 December 2020

An oxidative stress-mediated positive-feedback iron uptake loop in neuronal cells.

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12 December 2020

Acidosis potentiates oxidative neuronal death by multiple mechanisms

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12 December 2020

The ceruloplasmin and transferrin system in cerebrospinal fluid of acute leukemia patients

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12 December 2020

Iron homeostasis in neuronal cells: a role for IREG1

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12 December 2020

Influence of calcium and iron on cell death and mitochondrial function in oxidatively stressed astrocytes

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12 December 2020

A histochemical study of iron‐positive cells in the developing rat brain

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12 December 2020

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12 December 2020

Accumulation of iron by primary rat hepatocytes in long-term culture: changes in nuclear shape mediated by non-transferrin-bound forms of iron.

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12 December 2020

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

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12 December 2020

The functional significance of brain metallothioneins

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12 December 2020

Citrate and alpha‐ketoglutarate in cerebrospinal fluid and blood

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12 December 2020

Role of ceruloplasmin in cellular iron uptake

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12 December 2020

Increased mast cell degranulation within thalamus in early pre-lesion stages of an experimental model of Wernicke's encephalopathy

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12 December 2020

Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia

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12 December 2020

Mitochondrial respiratory enzymes are a major target of iron toxicity in rat heart cells

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12 December 2020

Neuronal and glial cell number in the hippocampus after experimental traumatic brain injury: analysis by stereological estimation

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12 December 2020

Ascorbic acid homeostasis in the central nervous system

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12 December 2020

Regulation and developmental expression of the divalent metal-ion transporter in the rat brain

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12 December 2020

Trace metal regulation of neuronal apoptosis: from genes to behavior

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12 December 2020

In vivo lipid peroxidation in rat brain following intracortical Fe2+ injection

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12 December 2020

Control of cellular iron homeostasis by iron-responsive elements in vivo

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12 December 2020

Non-ferritin, non-heme iron pools in rat tissues

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12 December 2020

The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes.

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12 December 2020

Influence of iron overload on manganese, zinc, and copper concentration in rat tissues in vivo: study of liver, spleen, and brain

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12 December 2020

Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism

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12 December 2020

Iron: a pathological mediator of Alzheimer disease?

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12 December 2020

Transferrin receptor number, synthesis, and endocytosis during erythropoietin-induced maturation of Friend virus-infected erythroid cells.

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12 December 2020

Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases

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12 December 2020

Dynamics of the cytosolic chelatable iron pool of K562 cells

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12 December 2020

Comparison of methods used to measure serum iron in the presence of iron gluconate or iron dextran

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12 December 2020

Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter.

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12 December 2020

Free radicals and brain damage.

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12 December 2020

Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system.

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12 December 2020

Induction of metallothionein in astrocytes by cytokines and heavy metals

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12 December 2020

Hemosiderin: nature, formation, and significance

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12 December 2020

Newly delivered transferrin iron and oxidative cell injury

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12 December 2020

Infusion of iron into the rat substantia nigra: nigral pathology and dose-dependent loss of striatal dopaminergic markers

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12 December 2020

Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

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12 December 2020

Deferoxamine reduces CSF free iron levels following intracerebral hemorrhage.

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12 December 2020

The history of iron in the brain

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12 December 2020

Oxidative mechanisms in the toxicity of metal ions

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12 December 2020

Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system

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12 December 2020

Astrocyte-endothelial interactions at the blood-brain barrier

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12 December 2020

Manganese: a transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of parkinsonism

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12 December 2020

Transport of iron in the blood-brain-cerebrospinal fluid system.

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12 December 2020

Ferritin induction protects cortical astrocytes from heme-mediated oxidative injury

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12 December 2020

Iron and iron management proteins in neurobiology

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12 December 2020

The metabolism of neuronal iron and its pathogenic role in neurological disease: review

1 reference

12 December 2020

Ferrous-citrate complex and nigral degeneration: evidence for free-radical formation and lipid peroxidation.

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12 December 2020

Multifunctional drugs with different CNS targets for neuropsychiatric disorders

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12 December 2020

The effect of human serum transferrin and milk lactoferrin on hydroxyl radical formation from superoxide and hydrogen peroxide

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12 December 2020

Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?

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12 December 2020

Association study between iron-related genes polymorphisms and Parkinson's disease

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12 December 2020

Transferrin receptor on endothelium of brain capillaries

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12 December 2020

Evidence that transferrin supports cell proliferation by supplying iron for DNA synthesis

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12 December 2020

High-field magnetic resonance imaging of brain iron: birth of a biomarker?

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12 December 2020

Entry of iron into cells: a new role for the transferrin receptor in modulating iron release from transferrin

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12 December 2020

Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells.

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12 December 2020

Intracerebral injection of autologous whole blood in rats: time course of inflammation and cell death

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12 December 2020

Iron metabolism and toxicity

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12 December 2020

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

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12 December 2020

Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms

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12 December 2020

Mitochondrial dysfunction in neurodegenerative diseases

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12 December 2020

Iron and iron-handling proteins in the brain after intracerebral hemorrhage.

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12 December 2020

Astrocytes enhance radical defence in capillary endothelial cells constituting the blood-brain barrier

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12 December 2020

The heme oxygenase system: a regulator of second messenger gases

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12 December 2020

Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide

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12 December 2020

Characterization and distribution of ferritin binding sites in the adult mouse brain.

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12 December 2020

Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells

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12 December 2020

A light and electron microscopic study of the iron transporter protein DMT-1 in the monkey cerebral neocortex and hippocampus

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12 December 2020

The cellular reactions to experimental intracerebral hemorrhage

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12 December 2020

The early reactions of non-neuronal cells to brain injury

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12 December 2020

Effects of iron deficiency on iron distribution and gamma-aminobutyric acid (GABA) metabolism in young rat brain tissues

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12 December 2020

The relevance of iron in the pathogenesis of Parkinson's disease.

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12 December 2020

Ferritin and hemosiderin in pathological tissues

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12 December 2020

Regional heterogeneity in the response of astrocytes following traumatic brain injury in the adult rat.

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12 December 2020

Rate of 59Fe uptake into brain and cerebrospinal fluid and the influence thereon of antibodies against the transferrin receptor

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12 December 2020

Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome

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12 December 2020

An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro.

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12 December 2020

Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier

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12 December 2020

A clinical evaluation of serum ferritin as an index of iron stores

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12 December 2020

Early loss of astrocytes after experimental traumatic brain injury

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12 December 2020

Low molecular weight iron from guinea pig reticulocytes isolated by Sephadex G-25 chromatography

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12 December 2020

Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography

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12 December 2020

Effects of S-glutathionylation and S-nitrosylation on calmodulin binding to triads and FKBP12 binding to type 1 calcium release channels.

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12 December 2020

Iron overload and antioxidative role of perivascular astrocytes in aceruloplasminemia

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12 December 2020

The role of iron neurotoxicity in ischemic stroke

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12 December 2020

Are hereditary hemochromatosis mutations involved in Alzheimer disease?

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12 December 2020

Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease.

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12 December 2020

Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier

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12 December 2020

Iron and neurodegenerative disorders

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12 December 2020

Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid

1 reference

12 December 2020

Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier.

1 reference

12 December 2020

Hemin-induced apoptosis in PC12 and neuroblastoma cells: Implications for local neuronal death associated with intracerebral hemorrhage

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12 December 2020

Glial cells protect neurons against oxidative stress via transcriptional up-regulation of the glutathione synthesis

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12 December 2020

The role of metals in neurodegenerative diseases.

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12 December 2020

Heme oxygenase-1 is induced in glia throughout brain by subarachnoid hemoglobin

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12 December 2020

Pharmacokinetics and brain uptake of lactoferrin in rats

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12 December 2020

Astrocyte-mediated control of cerebral blood flow

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12 December 2020

Long-term effects of experimental intracerebral hemorrhage: the role of iron

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12 December 2020

Effects of increasing intracellular reactive iron level on cardiac function and oxidative injury in the isolated rat heart

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12 December 2020

Brain iron uptake and homeostatic mechanisms: an overview

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12 December 2020

Metal ion transporters in mammals: structure, function and pathological implications

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12 December 2020

Effects of atypical antioxidative agents, S-nitrosoglutathione and manganese, on brain lipid peroxidation induced by iron leaking from tissue disruption.

1 reference

12 December 2020

The determination of non-heme iron and transferrin in cerebrospinal fluid

1 reference

12 December 2020

Cerebral Vasospasm and Hemoglobins—Clinical and Experimental Studies

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12 December 2020

Ferritin: a cytoprotective antioxidant strategem of endothelium

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12 December 2020

Receptor-mediated transcytosis of transferrin across the blood-brain barrier

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12 December 2020

Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical

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12 December 2020

P-Glycoprotein, a gatekeeper in the blood-brain barrier

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12 December 2020

In situ hybridization analysis of glial fibrillary acidic protein mRNA reveals evidence of biphasic astrocyte activation during acute experimental autoimmune encephalomyelitis

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12 December 2020

The effect of age on the non-haemin iron in the human brain.

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12 December 2020

Oxidative stress and neurodegeneration: where are we now?

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12 December 2020

Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate.

1 reference

12 December 2020

Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease.

1 reference

12 December 2020

Brain iron pathways and their relevance to Parkinson's disease.

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12 December 2020

Expression of transferrin mRNA in the CNS of normal and jimpy mice

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12 December 2020

Iron transport: emerging roles in health and disease

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12 December 2020

Iron in the basal ganglia in Parkinson's disease. An in vitro study using extended X-ray absorption fine structure and cryo-electron microscopy

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12 December 2020

Role for glia in synaptogenesis

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12 December 2020

Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.

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12 December 2020

Disturbance of iron metabolism in Parkinson's disease -- ultrasonography as a biomarker

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12 December 2020

Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress

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12 December 2020

Iron-induced oxidative damage and apoptosis in cerebellar granule cells: attenuation by tetramethylpyrazine and ferulic acid

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12 December 2020

Altered brain metabolism of iron as a cause of neurodegenerative diseases?

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12 December 2020

The role of iron in the basal ganglion

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12 December 2020

Lactoferrin, lysozyme, and beta 2-microglobulin in cerebrospinal fluid. Elevated levels in patients with acute cerebrovascular lesions as indices of inflammation

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12 December 2020

Decreased glutathione results in calcium-mediated cell death in PC12.

1 reference

12 December 2020

Quantitative analysis of cell death and ferritin expression in response to cortical iron: implications for hypoxia-ischemia and stroke

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12 December 2020

Brain iron transport and neurodegeneration

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12 December 2020

Transferrin and transferrin receptor function in brain barrier systems

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12 December 2020

Neurotoxicity of hemoglobin in cortical cell culture

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12 December 2020

Ascorbic-acid-mediated iron release from cellular ferritin and its relation to the formation of DNA strand breaks in neuroblastoma cells.

1 reference

12 December 2020

Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

1 reference

12 December 2020

Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain

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12 December 2020

Abnormal iron delivery to the bone marrow in neonatal hypotransferrinemic mice

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12 December 2020

Iron concentration reduced in ventral pallidum, globus pallidus, and substantia nigra by GABA-transaminase inhibitor, gamma-vinyl GABA.

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12 December 2020

Iron, brain ageing and neurodegenerative disorders

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12 December 2020

Iron and transferrin uptake by brain and cerebrospinal fluid in the rat

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12 December 2020

Echogenicity of the substantia nigra in relatives of patients with sporadic Parkinson's disease

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12 December 2020

10.1007/S11064-007-9290-4

Identifiers

DOI

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16 August 2017

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