(Q36786075)

16 August 2017

1 reference

title

PDGF receptors as targets in tumor treatment (English)

1 reference

16 August 2017

Arne Ostman

1

1 reference

PubMed ID

17419949

16 August 2017

Carl-Henrik Heldin

series ordinal

2

1 reference

16 August 2017

1 January 2007

1 reference

Advances in Cancer Research

16 August 2017

1 reference

16 August 2017

97

1 reference

16 August 2017

247-274

1 reference

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

16 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Lymphangiogenesis in development and human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Targeting the platelet-derived growth factor receptor in antivascular therapy for human ovarian carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Effect of platelet-derived growth factor receptor-beta inhibition with STI571 on radioimmunotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Imatinib mesylate inhibits Leydig cell tumor growth: evidence for in vitro and in vivo activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Insight into the physiological functions of PDGF through genetic studies in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Biology of gastrointestinal stromal tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha platelet-derived growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: a patient series

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Tissue plasminogen activator is a potent activator of PDGF-CC

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Characterization of an imatinib-sensitive subset of high-grade human glioma cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PDGFRA activating mutations in gastrointestinal stromal tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Clinical and molecular studies of the effect of imatinib on advanced aggressive fibromatosis (desmoid tumor).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Mechanism of action and in vivo role of platelet-derived growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

New members of the platelet-derived growth factor family of mitogens

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

High interstitial fluid pressure - an obstacle in cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Delivery of molecular and cellular medicine to solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab', leads to fluid accumulation and is associated with increased tumor vascularized volume.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Autocrine PDGFR signaling promotes mammary cancer metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Oncogenic derivatives of platelet-derived growth factor receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Identification of a putative Syp substrate, the PDGF beta receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Predimerization of recombinant platelet-derived growth factor receptor extracellular domains increases antagonistic potency

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Novel PDGF family members: PDGF-C and PDGF-D.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Platelet-derived growth factor BB-mediated normalization of dermal interstitial fluid pressure after mast cell degranulation depends on beta3 but not beta1 integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Imatinib mesylate (Gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor alpha and Akt inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Dermatofibrosarcoma protuberans: a surgical disease with a molecular savior

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Sunitinib malate for the treatment of solid tumours: a review of current clinical data

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Imatinib mesylate as a novel treatment option for hypereosinophilic syndrome: two case reports and a comprehensive review of the literature

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era--a population-based study in western Sweden

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Involvement of platelet-derived growth factor in disease: development of specific antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PDGF receptors as cancer drug targets

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Platelet-Derived Growth Factor is AngiogenicIn Vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Platelet-derived growth factor BB for the treatment of chronic pressure ulcers

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

A novel physiological function for platelet-derived growth factor-BB in rat dermis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Human breast carcinoma desmoplasia is PDGF initiated.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

KIT and platelet-derived growth factor receptor alpha tyrosine kinase gene mutations and KIT amplifications in human solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor alpha receptor: a new clinical target for STI571/Glivec

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

A potential oncogenic activity of platelet-derived growth factor d in prostate cancer progression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9;4)(q33;q12q25) and a CDK5RAP2-PDGFRA fusion gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Pericytes limit tumor cell metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997011-0

7 January 2021

10.1016/S0065-230X(06)97011-0

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17419949