(Q36792820)

English

Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites

scientific article published on November 1998

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scholarly article

1 reference

Europe PubMed Central

16 August 2017

Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites (English)

1 reference

Europe PubMed Central

16 August 2017

author name string

Y Kwok

1

1 reference

Europe PubMed Central

16 August 2017

Q Zeng

2

1 reference

Europe PubMed Central

16 August 2017

L H Hurley

3

1 reference

Europe PubMed Central

16 August 2017

language of work or name

0 references

publication date

1 November 1998

1 reference

Europe PubMed Central

16 August 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

16 August 2017

95

1 reference

Europe PubMed Central

16 August 2017

23

1 reference

Europe PubMed Central

16 August 2017

13531-13536

1 reference

Europe PubMed Central

16 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC24853/fullTextXML

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inferred from PubMed Central ID database lookup

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1 reference

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29 September 2017

DNA topoisomerases

1 reference

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Mutational analysis of a type II topoisomerase cleavage site: distinct requirements for enzyme and inhibitors

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Effects of base mutations on topoisomerase II DNA cleavage stimulated by mAMSA in short DNA oligomers

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Evidence for a conformational change in the DNA gyrase-DNA complex from hydroxyl radical footprinting

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DNA topoisomerases: essential enzymes and lethal targets

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Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex

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DNA topoisomerase poisons as antitumor drugs

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Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum.

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Apurinic sites are position-specific topoisomerase II poisons.

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Mechanism of quinolone action. A drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV.

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Hedamycin intercalates the DNA helix and, through carbohydrate-mediated recognition in the minor groove, directs N7-alkylation of guanine in the major groove in a sequence-specific manner

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Structure of the altromycin B (N7-guanine)-DNA adduct. A proposed prototypic DNA adduct structure for the pluramycin antitumor antibiotics

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Molecular struggle for transcriptional control

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Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

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Abasic sites stimulate double-stranded DNA cleavage mediated by topoisomerase II. DNA lesions as endogenous topoisomerase II poisons

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Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

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Human DNA topoisomerase II: evaluation of enzyme activity in normal and neoplastic tissues

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Visualization of an unwound DNA duplex

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Mechanism of action of the antileukemic xanthone psorospermin: DNA strand breaks, abasic sites, and protein-DNA cross-links

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1 reference

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Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons

1 reference

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Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

1 reference

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based on heuristic

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Identifiers

10.1073/PNAS.95.23.13531

1 reference

Europe PubMed Central

16 August 2017

1998PNAS...9513531K

0 references

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

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