(Q36823693)

16 August 2017

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title

The suicide gene therapy challenge: how to improve a successful gene therapy approach (English)

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16 August 2017

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7

Claudio Bordignon

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16 August 2017

6

Fabio Ciceri

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16 August 2017

Chiara Bonini

1

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16 August 2017

Attilio Bondanza

2

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16 August 2017

Serena Kimi Perna

3

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16 August 2017

Shin Kaneko

4

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16 August 2017

Catia Traversari

5

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16 August 2017

publication date

8 May 2007

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16 August 2017

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16 August 2017

volume

15

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16 August 2017

issue

7

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16 August 2017

page(s)

1248-1252

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HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia

16 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Evidence for increased risk of secondary graft failure after in vivo depletion of suicide gene-modified T lymphocytes transplanted in conjunction with CD34+-enriched blood stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Antitumor effects of HSV-TK engineered donor lymphocytes after allogeneic stem-cell transplantation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Haematopoietic cell transplantation as immunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Improving the ex vivo retroviral-mediated suicide-gene transfer process in T lymphocytes to preserve immune function.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

"Suicide" gene for the control of graft-versus-host disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Modulation of GvHD by suicide-gene transduced donor T lymphocytes: clinical applications in mismatched transplantation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Safety of retroviral gene marking with a truncated NGF receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Retroviral vector insertions in T-lymphocytes used for suicide gene therapy occur in gene groups with specific molecular functions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Production and culture of HSVtk transduced suicidal lymphocytes induces variable changes in the lymphocyte subset composition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Preferential retroviral-mediated transduction of EBV- and CMV-specific T cells after polyclonal T-cell activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Retrovirus-mediated gene transfer in primary T lymphocytes impairs their anti-Epstein-Barr virus potential through both culture-dependent and selection process-dependent mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Retrovirus-mediated gene transfer in primary T lymphocytes: influence of the transduction/selection process and of ex vivo expansion on the T cell receptor beta chain hypervariable region repertoire

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

CD28 costimulation and immunoaffinity-based selection efficiently generate primary gene-modified T cells for adoptive immunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Transduction and selection of human T cells with novel CD34/thymidine kinase chimeric suicide genes for the treatment of graft-versus-host disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Lentiviral vector-mediated gene transfer in T cells from Wiskott-Aldrich syndrome patients leads to functional correction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

HIV-1 integration in the human genome favors active genes and local hotspots

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Transcription start regions in the human genome are favored targets for MLV integration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Lentiviral vectors for T-cell suicide gene therapy: preservation of T-cell effector function after cytokine-mediated transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Genetic modification of human T cells with CD20: a strategy to purify and lyse transduced cells with anti-CD20 antibodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

CD34 splice variant: an attractive marker for selection of gene-modified cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Characterization of CD20-transduced T lymphocytes as an alternative suicide gene therapy approach for the treatment of graft-versus-host disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Immunotherapy for non-Hodgkin's lymphoma: monoclonal antibodies and vaccines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Kinetics of cell death in T lymphocytes genetically modified with two novel suicide fusion genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Kinetics of in vivo elimination of suicide gene-expressing T cells affects engraftment, graft-versus-host disease, and graft-versus-leukemia after allogeneic bone marrow transplantation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Enhanced ouabain resistance gene as a eukaryotic selection marker.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Suicide gene-mediated modulation of graft-versus-host disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Elimination of the truncated message from the herpes simplex virus thymidine kinase suicide gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

T cell transduction and suicide with an enhanced mutant thymidine kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

An inducible caspase 9 safety switch for T-cell therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

The CD20/alphaCD20 'suicide' system: novel vectors with improved safety and expression profiles and efficient elimination of CD20-transgenic T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Intravenous safety and pharmacokinetics of a novel dimerizer drug, AP1903, in healthy volunteers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300190

7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300190

1 reference

16 August 2017

1 reference