(Q36828630)

English

Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene

scientific article published on 13 July 2007

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

4

object named as

Judy L Bolton

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

author name string

Hong Liu

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Zhihui Qin

2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Gregory R J Thatcher

3

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

publication date

13 July 2007

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Chemical Research in Toxicology

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

20

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

11

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

1676-1684

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Bioactivation of Selective Estrogen Receptor Modulators (SERMs)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

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The role of Keap1 in cellular protective responses

1 reference

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29 September 2017

A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats

1 reference

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29 September 2017

Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

29 September 2017

Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

29 September 2017

Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

29 September 2017

Randomized, double-blind, multicenter trial comparing two doses of arzoxifene (LY353381) in hormone-sensitive advanced or metastatic breast cancer patients.

1 reference

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29 September 2017

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation

1 reference

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29 September 2017

Proteomic approaches to characterize protein modifications: new tools to study the effects of environmental exposures

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29 September 2017

Peroxidase-catalyzed formation of quercetin quinone methide-glutathione adducts.

1 reference

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29 September 2017

Carcinogen macromolecular adducts and their measurement

1 reference

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29 September 2017

Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissue

1 reference

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29 September 2017

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

1 reference

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29 September 2017

Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

29 September 2017

A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

29 September 2017

Genotoxic effects of estrogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

29 September 2017

Potential role of tamoxifen in prevention of breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

29 September 2017

Uterine peroxidase as a marker for estrogen action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

29 September 2017

Oxidation of indole-3-acetic acid by dioxygen catalysed by plant peroxidases: specificity for the enzyme structure.

1 reference

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27 June 2018

Evidence that the catechol 3,4-Dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

27 June 2018

One- and two-electron oxidation of reduced glutathione by peroxidases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

27 June 2018

Formation of tamoxifen-DNA adducts in human endometrial explants exposed to alpha-hydroxytamoxifen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

5 September 2018

Detection of hydrogen peroxide with Amplex Red: interference by NADH and reduced glutathione auto-oxidation

1 reference

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5 September 2018

Biotransformation of tamoxifen in a human endometrial explant culture model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

5 September 2018

Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species.

1 reference

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5 September 2018

Identification of tamoxifen-DNA adducts in monkeys treated with tamoxifen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

5 September 2018

A phase II trial of arzoxifene, a selective estrogen response modulator, in patients with recurrent or advanced endometrial cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507766

5 September 2018

Sol-gel encapsulated horseradish peroxidase: a catalytic material for peroxidation

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Gamma-glutamyl transpeptidase in transgenic tobacco plants. Cellular localization, processing, and biochemical properties

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Effects of the new selective estrogen receptor modulator LY353381.HCl (Arzoxifene) on human endometrial cancer growth in athymic mice.

1 reference

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Cytosine-phosphoguanine methylation of estrogen receptors in endometrial cancer.

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5 September 2018

Identification of tamoxifen-DNA adducts in the endometrium of women treated with tamoxifen.

1 reference

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5 September 2018

Tamoxifen metabolism in rat liver microsomes: identification of a dimeric metabolite derived from free radical intermediates by liquid chromatography/mass spectrometry.

1 reference

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5 September 2018

Activation of 4-hydroxytamoxifen and the tamoxifen derivative metabolite E by uterine peroxidase to form DNA adducts: comparison with DNA adducts formed in the uterus of Sprague-Dawley rats treated with tamoxifen.

1 reference

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5 September 2018

Activation of the tamoxifen derivative metabolite E to form DNA adducts: comparison with the adducts formed by microsomal activation of tamoxifen

1 reference

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Peroxidase activity in glands and stroma of human endometrium.

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Incidence of New Primary Cancers After Adjuvant Tamoxifen Therapy and Radiotherapy for Early Breast Cancer

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Alpha-hydroxytamoxifen is a substrate of hydroxysteroid (alcohol) sulfotransferase, resulting in tamoxifen DNA adducts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of horseradish peroxidase catalyzed epinephrine oxidation: obligatory role of endogenous O2- and H2O2

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

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based on heuristic

inferred from PubMed ID database lookup

The effect of estrogen on the production of a peroxidase in the rat uterus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tamoxifen in the treatment of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of endometrial cancer after tamoxifen treatment of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tamoxifen-DNA adducts formed by alpha-acetoxytamoxifen N-oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative metabolism of butylated hydroxytoluene by hepatic and pulmonary microsomes from rats and mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative studies on estrogen-dependent peroxidases contained in uterine microsomes and fluid of rats and pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of estrogen on glutathione levels and glutathione-metabolizing enzymes in uteri and R3230AC mammary tumors of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17630709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/TX7001367

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

ResearchGate publication ID

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