(Q36836706)

16 August 2017

5 references

22 March 2019

2 October 2019

10 October 2019

20 November 2019

4 December 2020

Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter? (English)

1 reference

16 August 2017

pulmonary hypertension

4 references

22 March 2019

2 October 2019

10 October 2019

20 November 2019

1 reference

2 October 2019

1 reference

10 October 2019

1 reference

20 November 2019

antihypertensive drug

1 reference

4 December 2020

Christian F Opitz

1

1 reference

16 August 2017

Ralf Ewert

series ordinal

2

1 reference

16 August 2017

Wilhelm Kirch

series ordinal

3

1 reference

16 August 2017

David Pittrow

series ordinal

4

1 reference

16 August 2017

language of work or name

1 reference

17 June 2008

1 reference

16 August 2017

1 August 2008

5 references

22 March 2019

2 October 2019

10 October 2019

20 November 2019

4 December 2020

European Heart Journal

6 references

16 August 2017

22 March 2019

2 October 2019

10 October 2019

20 November 2019

4 December 2020

29

1 reference

16 August 2017

16

1 reference

16 August 2017

1936-1948

1 reference

Creative Commons Attribution-NonCommercial

16 August 2017

5 references

22 March 2019

2 October 2019

10 October 2019

20 November 2019

4 December 2020

on focus list of Wikimedia project

ScienceSource

0 references

cites work

Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities

1 reference

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29 September 2017

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29 September 2017

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Selective endothelin A receptor antagonism with sitaxsentan for pulmonary arterial hypertension associated with connective tissue disease

29 September 2017

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29 September 2017

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Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2.

29 September 2017

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29 September 2017

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Dual ET(A)/ET(B) vs. selective ET(A) endothelin receptor antagonism in patients with pulmonary hypertension

29 September 2017

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Bosentan treatment for pulmonary arterial hypertension related to connective tissue disease: a subgroup analysis of the pivotal clinical trials and their open-label extensions.

29 September 2017

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Systemic sclerosis associated pulmonary hypertension: improved survival in the current era.

29 September 2017

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Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension

29 September 2017

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Role of endothelin in fibrosis and anti-fibrotic potential of bosentan

29 September 2017

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Fluorescence resonance energy transfer analysis reveals the existence of endothelin-A and endothelin-B receptor homodimers

29 September 2017

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Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1

29 September 2017

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Survival with first-line bosentan in patients with primary pulmonary hypertension.

29 September 2017

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29 September 2017

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End points and clinical trial designs in pulmonary arterial hypertension: clinical and regulatory perspectives

29 September 2017

1 reference

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Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

29 September 2017

1 reference

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Effects of bosentan on cellular processes involved in pulmonary arterial hypertension: do they explain the long-term benefit?

29 September 2017

1 reference

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29 September 2017

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Endothelin-1 stimulates human colonic myofibroblast contraction and migration

29 September 2017

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The heart and pulmonary vasculature in scleroderma: clinical features and pathobiology

29 September 2017

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Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.

29 September 2017

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Regression of renal vascular fibrosis by endothelin receptor antagonism

29 September 2017

1 reference

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Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism

29 September 2017

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Endothelin receptor antagonists and their developing role in cardiovascular therapeutics.

29 September 2017

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Hemodynamic effects of Bosentan, an endothelin receptor antagonist, in patients with pulmonary hypertension

29 September 2017

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29 September 2017

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Endothelin-1 inhibits endothelin-converting enzyme-1 expression in cultured rat pulmonary endothelial cells

29 September 2017

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Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease

29 September 2017

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Changes in collagen metabolism in response to endothelin-1: evidence for fibroblast heterogeneity.

29 September 2017

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Acute pro-inflammatory actions of endothelin-1 in the guinea-pig lung: involvement of ETA and ETB receptors

29 September 2017

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Growth inhibitory properties of endothelin-1 in human hepatic myofibroblastic Ito cells. An endothelin B receptor-mediated pathway

29 September 2017

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Possible role of endothelin in endothelial regulation of vascular tone

29 September 2017

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A novel potent vasoconstrictor peptide produced by vascular endothelial cells

29 September 2017

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Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension

29 September 2017

1 reference

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Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop

27 June 2018

1 reference

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ETA-receptor antagonist prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat.

27 June 2018

1 reference

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Survival in patients with primary pulmonary hypertension. Results from a national prospective registry.

27 June 2018

1 reference

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Endothelin, an endothelial-dependent vasoconstrictor in scleroderma. Enhanced production and profibrotic action

27 June 2018

1 reference

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Mutual pharmacokinetic interactions between steady-state bosentan and sildenafil

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Results of European post-marketing surveillance of bosentan in pulmonary hypertension.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Effect of bosentan on plasma endothelin-1 concentration in patients with pulmonary arterial hypertension.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Long-term outcome with first-line bosentan therapy in idiopathic pulmonary arterial hypertension.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Ambrisentan therapy for pulmonary arterial hypertension

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Sustained symptomatic, functional, and hemodynamic benefit with the selective endothelin-A receptor antagonist, sitaxsentan, in patients with pulmonary arterial hypertension: a 1-year follow-up study

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Are selective endothelin A receptor antagonists better than mixed antagonists?

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Simultaneous blockade of endothelin A and B receptors in ischemic acute renal failure is detrimental to long-term kidney function

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Short-term oral endothelin-receptor antagonist therapy in conventionally treated patients with symptomatic severe chronic heart failure.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: Relation to hemodynamic variables and endothelin levels

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Experience with inhaled iloprost and bosentan in portopulmonary hypertension

20 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology

4 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Pulmonary Fibrosis and Chronic Lung Inflammation in ET-1 Transgenic Mice

4 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2515885

Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension

4 December 2018

1 reference

12 December 2020

Reduced pulmonary clearance of endothelin-1 in pulmonary hypertension

1 reference

12 December 2020

Sitaxsentan treatment for patients with pulmonary arterial hypertension discontinuing bosentan

1 reference

12 December 2020

Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes

1 reference

12 December 2020

The value of approved therapies for pulmonary arterial hypertension

1 reference

12 December 2020

Angiotensin II type 1 and endothelin type A receptor antagonists modulate the extracellular matrix regulatory system differently in diastolic heart failure

1 reference

12 December 2020

Pulmonary Arterial Hypertension

1 reference

12 December 2020

Endothelin-1 induces an increase in total protein synthesis and expression of the smooth muscle alpha-actin gene in vascular smooth muscle cells

1 reference

12 December 2020

Endothelin-1-induced pulmonary vasoreactivity is regulated by ET(A) and ET(B) receptor interactions

1 reference

12 December 2020

The selective endothelin ETA receptor antagonist BQ123 antagonizes endothelin-1-mediated mitogenesis

1 reference

12 December 2020

Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats

1 reference

12 December 2020

Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan

1 reference

12 December 2020

Endothelin adrenocortical secretagogue effect is mediated by the B receptor in rats

1 reference

12 December 2020

Endothelin receptor antagonism in patients with chronic heart failure

1 reference

12 December 2020

Expression of endothelin-1, endothelin-3, endothelin-converting enzyme-1, and endothelin-A and endothelin-B receptor mRNA after angioplasty-induced neointimal formation in the rat

1 reference

12 December 2020

Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary hypertension: a placebo-controlled study

1 reference

12 December 2020

Increased endothelin-1 in bleomycin-induced pulmonary fibrosis and the effect of an endothelin receptor antagonist

1 reference

12 December 2020

Stress upregulates arterial matrix metalloproteinase expression and activity via endothelin A receptor activation

1 reference

12 December 2020

Are there different ETB receptors mediating constriction and relaxation?

1 reference

12 December 2020

Endothelin-1 regulation of intercellular adhesion molecule-1 expression in normal and sclerodermal fibroblasts

1 reference

12 December 2020

Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist

1 reference

12 December 2020

The orally active nonpeptide endothelin A-receptor antagonist A-127722 prevents and reverses hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling in Sprague-Dawley rats

1 reference

12 December 2020

The 6-min walk test (6MW) as an efficacy endpoint in pulmonary arterial hypertension clinical trials: demonstration of a ceiling effect

1 reference

12 December 2020

Bosentan therapy for pulmonary arterial hypertension

1 reference

12 December 2020

Endothelin-1 as an autocrine/paracrine apoptosis survival factor for endothelial cells

1 reference

12 December 2020

Etiology-specific endothelin-1 clearance in human precapillary pulmonary hypertension

1 reference

12 December 2020

Acute endothelin A receptor blockade causes selective pulmonary vasodilation in patients with chronic heart failure

1 reference

12 December 2020

Effect of the endothelin-receptor antagonist bosentan on the pharmacokinetics and pharmacodynamics of warfarin

1 reference

12 December 2020

Effect of a specific endothelin A receptor antagonist on murine lupus nephritis

1 reference

12 December 2020

Identifiers

DOI

10.1093/EURHEARTJ/EHN234

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

18562303

1 reference