(Q36842495)

16 August 2017

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title

Blood-brain barrier transport of non-viral gene and RNAi therapeutics (English)

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16 August 2017

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1

Ruben J Boado

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16 August 2017

publication date

8 June 2007

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16 August 2017

published in

Pharmaceutical Research

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16 August 2017

volume

24

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16 August 2017

issue

9

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16 August 2017

page(s)

1772-1787

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Gene therapy of the brain: the trans-vascular approach

16 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS11095-007-9321-5

Components of vectors for gene transfer and expression in mammalian cells

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS11095-007-9321-5

Stimulation of mitogenic pathways through kinase-impaired mutants of the epidermal growth factor receptor

21 January 2018

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12 December 2020

Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes

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12 December 2020

Pre-existing herpes simplex virus 1 (HSV-1) immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vector

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12 December 2020

Breakthrough of the year. Small RNAs make big splash

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12 December 2020

RNA interference and nonviral targeted gene therapy of experimental brain cancer

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12 December 2020

Analysis of gene function in somatic mammalian cells using small interfering RNAs

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12 December 2020

Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer

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12 December 2020

Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response.

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12 December 2020

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors

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12 December 2020

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

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12 December 2020

Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion

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12 December 2020

PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli

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12 December 2020

Inflammatory responses and their impact on beta-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleus

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12 December 2020

Absence of toxicity of chronic weekly intravenous gene therapy with pegylated immunoliposomes

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12 December 2020

Stealth liposomes and tumor targeting: one step further in the quest for the magic bullet

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12 December 2020

Receptor-mediated delivery of an antisense gene to human brain cancer cells

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12 December 2020

Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter

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12 December 2020

Abnormal expression of hepatoma specific gamma-glutamyl transferase and alteration of gamma-glutamyl transferase gene methylation status in patients with hepatocellular carcinoma

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12 December 2020

Intra-CSF administered recombinant adenovirus causes an immune response-mediated toxicity

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12 December 2020

Immune responses to adenovirus vectors in the nervous system

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12 December 2020

Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes

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12 December 2020

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

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12 December 2020

Decline in exogenous gene expression in primate brain following intravenous administration is due to plasmid degradation.

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12 December 2020

Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse.

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12 December 2020

Gene targeting in vivo with pegylated immunoliposomes

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12 December 2020

Stabilized plasmid-lipid particles: factors influencing plasmid entrapment and transfection properties

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12 December 2020

5' upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice.

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12 December 2020

Localization of GTP cyclohydrolase in monoaminergic but not nitric oxide-producing cells.

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12 December 2020

Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate

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12 December 2020

Immunocytochemical localization of GTP cyclohydrolase I in the brain, adrenal gland, and liver of mice

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12 December 2020

Ten nucleotide cis element in the 3'-untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization.

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12 December 2020

In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats

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12 December 2020

Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa).

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12 December 2020

Intracerebral injection of adenovirus harboring the HSVtk gene combined with ganciclovir administration: toxicity study in nonhuman primates

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12 December 2020

Cationic lipids are essential for gene delivery mediated by intravenous administration of lipoplexes

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12 December 2020

Adenovirus gene transfer causes inflammation in the brain

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12 December 2020

Antisense gene therapy of brain cancer with an artificial virus gene delivery system

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12 December 2020

Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.

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12 December 2020

Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates

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12 December 2020

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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12 December 2020

Tissue-specific and high-level expression of the human tyrosine hydroxylase gene in transgenic mice.

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12 December 2020

Drug and gene delivery to the brain: the vascular route

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12 December 2020

Suppression of EGFRvIII-mediated proliferation and tumorigenesis of breast cancer cells by ribozyme.

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12 December 2020

Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo.

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12 December 2020

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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12 December 2020

Immunohistochemical colocalization of GTP cyclohydrolase I in the nigrostriatal system with tyrosine hydroxylase

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12 December 2020

Humoral immune responses to adenovirus vectors in the brain

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12 December 2020

Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR.

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12 December 2020

Gene therapy: X-SCID transgene leukaemogenicity

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12 December 2020

Brain-specific expression of an exogenous gene after i.v. administration

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12 December 2020

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy

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12 December 2020

Pharmacokinetics, tissue distribution, and expression efficiency of plasmid [33P]DNA following intravenous administration of DNA/cationic lipid complexes in mice: use of a novel radionuclide approach

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12 December 2020

Marked enhancement in gene expression by targeting the human insulin receptor

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12 December 2020

Global non-viral gene transfer to the primate brain following intravenous administration.

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12 December 2020

A system for stable expression of short interfering RNAs in mammalian cells

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12 December 2020

Neutralisation of adenovirus infectivity by ascitic fluid from ovarian cancer patients

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12 December 2020

Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier

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12 December 2020

GTP cyclohydrolase I gene expression in the brains of male and female hph-1 mice

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12 December 2020

A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain.

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12 December 2020

Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer

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12 December 2020

Noninvasive gene targeting to the brain

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12 December 2020

Establishment of latent Epstein-Barr virus infection and stable episomal maintenance in murine B-cell lines

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12 December 2020

Density-dependent regulation of cell surface gamma-glutamyl transpeptidase in cultured glial cells

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12 December 2020

Gene therapy for Parkinson's disease: an approach to the prevention or palliation of levodopa-associated motor complications

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12 December 2020

Lentiviral-mediated RNA interference

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12 December 2020

Simultaneous inhibition of GSK3alpha and GSK3beta using hairpin siRNA expression vectors.

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12 December 2020

Nuclear accumulation of exogenous DNA fragments in viable cells mediated by FGF-2 and DNA release upon cellular injury

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12 December 2020

Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells

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12 December 2020

Amplification of gene expression using both 5'- and 3'-untranslated regions of GLUT1 glucose transporter mRNA.

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12 December 2020

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles

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12 December 2020

Loss of binding and entry of liposome-DNA complexes decreases transfection efficiency in differentiated airway epithelial cells

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12 December 2020

Nuclear signaling pathways for polypeptide ligands and their membrane receptors?

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12 December 2020

Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor

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12 December 2020

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

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12 December 2020

Gene silencing in mammals by small interfering RNAs

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12 December 2020

Lysophosphatidic acid inhibits Ca2+ signaling in response to epidermal growth factor receptor stimulation in human astrocytoma cells by a mechanism involving phospholipase C(gamma) and a G(alphai) protein

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12 December 2020

10.1007/S11095-007-9321-5

Identifiers

DOI

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16 August 2017

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