(Q36849517)

16 August 2017

CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo-Brief Report (English)

1 reference

16 August 2017

0 references

0 references

Xiao Wang

1

1 reference

16 August 2017

Avanthi Raghavan

2

1 reference

16 August 2017

Tao Chen

3

1 reference

16 August 2017

Lyon Qiao

4

1 reference

16 August 2017

Yongxian Zhang

5

1 reference

16 August 2017

Qiurong Ding

6

1 reference

16 August 2017

Kiran Musunuru

7

1 reference

16 August 2017

language of work or name

English

0 references

publication date

3 March 2016

1 reference

Arteriosclerosis, Thrombosis, and Vascular Biology

16 August 2017

1 reference

16 August 2017

36

1 reference

16 August 2017

783-786

1 reference

16 August 2017

5

1 reference

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

In vivo genome editing using Staphylococcus aureus Cas9

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Therapeutic genome editing: prospects and challenges

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Promoterless gene targeting without nucleases ameliorates haemophilia B in mice.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Mice with chimeric livers are an improved model for human lipoprotein metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

DNA targeting specificity of RNA-guided Cas9 nucleases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

In vivo genome editing restores haemostasis in a mouse model of haemophilia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

Extensive double humanization of both liver and hematopoiesis in FRGN mice.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4850082

10.1161/ATVBAHA.116.307227

27 June 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

16 August 2017

1 reference