(Q36857420)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

title

Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Ke Ding

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Ke Ding

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Krzysztof Krajewski

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

author name string

Zaneta Nikolovska-Coleska

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Chao-Yie Yang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Su Qiu

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Sanjeev Shangary

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Renxiao Wang

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Jie Guo

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Wei Gao

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Jennifer Meagher

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Jeanne Stuckey

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Sheng Jiang

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Peter P Roller

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Shaomeng Wang

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

language of work or name

English

0 references

publication date

7 June 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

Journal of Medicinal Chemistry

31 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

volume

50

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

page(s)

3163-3166

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

issue

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

Structural insights into the degradation of Mcl-1 induced by BH3 domains

31 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Solution structure of the antiapoptotic protein bcl-2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

The Bcl-2 protein family: arbiters of cell survival

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

BCL-2 family: regulators of cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Bcl-2 family proteins: strategies for overcoming chemoresistance in cancer

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527594

Recent progress on the regulation of apoptosis by Bcl-2 family members

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17552510

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17552510

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM070383C

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17552510%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference