(Q36860047)

16 August 2017

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title

Pharmacological models in healthy volunteers: their use in the clinical development of psychotropic drugs (English)

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16 August 2017

Christian Gilles

1

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16 August 2017

Remy Luthringer

series ordinal

2

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16 August 2017

language of work or name

English

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publication date

1 May 2007

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Journal of Psychopharmacology

16 August 2017

published in

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16 August 2017

volume

21

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16 August 2017

issue

3

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16 August 2017

page(s)

272-282

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Scopolamine-induced cognitive impairment as a predictor of cognitive decline in healthy elderly volunteers: a 6-year follow-up.

16 August 2017

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Effects of a tryptophan-free amino acid drink challenge on normal human sleep electroencephalogram and mood

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Monoamine depletion in psychiatric and healthy populations: review

21 January 2018

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Neuropathological stageing of Alzheimer-related changes

21 January 2018

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Effect of CI-988 on cholecystokinin tetrapeptide-induced panic symptoms in healthy volunteers

21 January 2018

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Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans.

21 January 2018

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Tryptophan depletion during continuous CSF sampling in healthy human subjects

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine.

21 January 2018

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Serotonin function in anxiety

21 January 2018

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The diagnostic utility of lactate sensitivity in panic disorder

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Differential amnesic properties of benzodiazepines: a dose-response comparison of two drugs with similar elimination half-lives

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Benzodiazepines, memory and mood: a review

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Models of memory dysfunction? A comparison of the effects of scopolamine and lorazepam on memory, psychomotor performance and mood

21 January 2018

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Cholecystokinin tetrapeptide induces panic-like attacks in healthy volunteers. Preliminary findings.

21 January 2018

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Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan.

21 January 2018

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Human memory and the cholinergic system. A relationship to aging?

21 January 2018

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Scopolamine and lorazepam exert different patterns of effects in a test battery assessing stages of information processing.

21 January 2018

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Differential effects of clozapine and haloperidol on ketamine-induced brain metabolic activation.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Chronic administration of haloperidol and olanzapine attenuates ketamine-induced brain metabolic activation

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Scopolamine model of dementia: electroencephalogram findings and cognitive performance.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Hypersensitivity to scopolamine in the elderly

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Multilead quantitative EEG profile of clozapine in resting and vigilance-controlled conditions.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Response to meta-chlorophenylpiperazine in panic disorder patients and healthy subjects: influence of reduction in intravenous dosage.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Pharmacology of human experimental anxiety

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Pharmacologic models of anxiety

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Electroencephalographic and psychomotor effects of chlorpromazine and risperidone relative to placebo in normal healthy volunteers

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Neuroanatomic correlates of CCK-4-induced panic attacks in healthy humans: a comparison of two time points

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Effects of NMDA Modulation in Scopolamine Dementiaa

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Effects of m-chlorophenylpiperazine in normal subjects: a dose-response study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Anxiety sensitivity and response to cholecystokinin tetrapeptide in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Behavioral, cardiovascular, and neuroendocrine profiles following CCK-4 challenge in healthy volunteers: a comparison of panickers and nonpanickers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Interactive effects of subanesthetic ketamine and haloperidol in healthy humans

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Schizophrenia, VIII: pharmacologic models

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Effects on mood of acute phenylalanine/tyrosine depletion in healthy women

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881107077733

Electroencephalographic characterization of brain dopaminergic stimulation by apomorphine in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Caffeine induced changes in cerebral circulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Behavioral and cerebrovascular effects of caffeine in patients with anxiety disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

A comparison of the central nervous system effects of haloperidol, chlorpromazine and sulpiride in normal volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Neuromodulation of frontal and temporal cortex by intravenous d-fenfluramine: an [15O]H2O PET study in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Increased left posterior parietal-temporal cortex activation after D-fenfluramine in women with panic disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

TRH attenuates scopolamine-induced memory impairment in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Rapid tryptophan depletion, sleep electroencephalogram, and mood in men with remitted depression on serotonin reuptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Clinical and physiological consequences of rapid tryptophan depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Differences between males and females in rates of serotonin synthesis in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

NMDA hypofunction in the posterior cingulate as a model for schizophrenia: an exploratory ketamine administration study in fMRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Effects of lorazepam on memory, attention and sedation in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Scopolamine and benzodiazepine models of dementia: cross-reversals by Ro 15-1788 and physostigmine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

A comparison of lactate and isoproterenol anxiety states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Brain aging: reorganizing discoveries about the aging mind

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

REM sleep effects as a biomarker for the effects of antidepressants in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Five percent carbon dioxide challenge: valid analogue and marker of panic disorder?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

The psychobiology of anxiolytic drugs. Part 1: Basic neurobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Scopolamine reduces persistent activity related to long-term encoding in the parahippocampal gyrus during delayed matching in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Functional magnetic resonance imaging characterization of CCK-4-induced panic attack and subsequent anticipatory anxiety.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Selective pharmacological activation of limbic structures in human volunteers: a positron emission tomography study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Effects of alprazolam on increases in hormonal and anxiety levels induced by meta-chlorophenylpiperazine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Effective decision-making: progressing compounds through clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

The effect of cholecystokinin tetrapeptide on respiratory resistance in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Functional MRI detection of pharmacologically induced memory impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Scopolamine challenges in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Panic attack frequency and vulnerability to anxiogenic challenge studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Scopolamine but not lorazepam modulates face repetition priming: a psychopharmacological fMRI study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

The effects of tryptophan depletion on mood and psychiatric symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)- and (R)-ketamine in healthy volunteers using positron emission tomography (PET)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Impact of experimentally induced serotonin deficiency by tryptophan depletion on sleep EEG in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Comparative pharmacology of the ketamine isomers. Studies in volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Tryptophan depletion causes a rapid lowering of mood in normal males

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Effects of alprazolam on cholecystokinin-tetrapeptide-induced panic and hypothalamic-pituitary-adrenal-axis activity: a placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

Effects of tiagabine on cholecystokinin-tetrapeptide (CCK-4)-induced anxiety in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881107077733

21 January 2018

Identifiers

DOI

10.1177/0269881107077733

1 reference

16 August 2017

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